The aim: to study the G894T gene polymorphism of the NOS3 gene on the risk of developing resistant arterial hypertension (AH) in Uzbek population. Materials and Methods: The study included 176 patients with I-III degree of AH, who are on outpatient treatment at the Republican Specialized Scientific and Practical Medical Center of Cardiology. Genomic DNA was isolated from whole blood using the DiatomTM DNA Prep 200 kit (Laboratory IsoGen, Russia) according to the manufacturer's standard protocol. The quantity and quality of isolated DNA were assessed using gel electrophoresis and a NanoDrop spectrophotometer (Thermo Scientific, USA). Gene polymorphisms were identified by real-time polymerase chain reaction using allele and gene-specific primers and probes.Results: An analysis using genetic models of inheritance revealed an association of the C allele T704C of the AGT gene polymorphism with resistant hypertension and a protective effect of the G allele G894T of the NOS3 gene polymorphism on the risk of developing resistant hypertension in the Uzbek population.Conclusion: C allele and CC genotype T704C of the AGT gene polymorphism are associated with resistant hypertension. Carrying the G allele and GG genotype G894T of the NOS3 gene polymorphism is associated with a low risk of developing resistant hypertension in Uzbek population.
| Mualliflar | Машарипов Ш.М, Абдуллаева Г.Ж, Хамидуллаева Г.А, Закирова Д.В, Абдуллаев А.А |
|---|---|
| Jurnal | Journal of cardiorespiratory research/Kardiorespirator tadqiqotlar jurnali |
| Nashriyot | Самарқанд давлат тиббиёт университети |
| Nashr sanasi | 2023-06-12 |
| Jild | 4 |
| Son | 1 |
| Til | Ingliz |
| Ilmiy soha | Tibbiyot |
| Indeksga qo‘shilgan | 2026-08-26 |
| APA | Машарипов Ш.М, Абдуллаева Г.Ж, Хамидуллаева Г.А, Закирова Д.В, & Абдуллаев А.А (2023). G894T NOS III GENE POLYMORPHISM AND RESISTANT HYPERTENSION IN THE UZBEK POPULATION. Journal of cardiorespiratory research/Kardiorespirator tadqiqotlar jurnali, 4(1). https://www.tadqiqot.uz/index.php/cardio/article/view/7446 |
|---|---|
| GOST (OAK) | Машарипов Ш.М va b. G894T NOS III GENE POLYMORPHISM AND RESISTANT HYPERTENSION IN THE UZBEK POPULATION // Journal of cardiorespiratory research/Kardiorespirator tadqiqotlar jurnali. – 2023. – T. 4, № 1. |
| MLA | Машарипов Ш.М, Абдуллаева Г.Ж, Хамидуллаева Г.А, Закирова Д.В, and Абдуллаев А.А. “G894T NOS III GENE POLYMORPHISM AND RESISTANT HYPERTENSION IN THE UZBEK POPULATION.” Journal of cardiorespiratory research/Kardiorespirator tadqiqotlar jurnali, 4(1), 2023. https://www.tadqiqot.uz/index.php/cardio/article/view/7446 |
| Chicago | Машарипов Ш.М, Абдуллаева Г.Ж, Хамидуллаева Г.А, Закирова Д.В, and Абдуллаев А.А. “G894T NOS III GENE POLYMORPHISM AND RESISTANT HYPERTENSION IN THE UZBEK POPULATION.” Journal of cardiorespiratory research/Kardiorespirator tadqiqotlar jurnali, 4(1) (2023). https://www.tadqiqot.uz/index.php/cardio/article/view/7446 |
| Harvard | Машарипов Ш.М, Абдуллаева Г.Ж, Хамидуллаева Г.А, Закирова Д.В, and Абдуллаев А.А (2023) ‘G894T NOS III GENE POLYMORPHISM AND RESISTANT HYPERTENSION IN THE UZBEK POPULATION’, Journal of cardiorespiratory research/Kardiorespirator tadqiqotlar jurnali, 4(1). https://www.tadqiqot.uz/index.php/cardio/article/view/7446 |
| BibTeX | @article{article2023,
title = {G894T NOS III GENE POLYMORPHISM AND RESISTANT HYPERTENSION IN THE UZBEK POPULATION},
author = {Машарипов Ш.М and Абдуллаева Г.Ж and Хамидуллаева Г.А and Закирова Д.В and Абдуллаев А.А},
journal = {Journal of cardiorespiratory research/Kardiorespirator tadqiqotlar jurnali},
year = {2023},
volume = {4},
number = {1},
url = {https://www.tadqiqot.uz/index.php/cardio/article/view/7446}
} |
Boshqa maqola uchun iqtibos tayyorlash
Gout is currently a serious medical problem, and the number of patients with gouty arthritis is steadily increasing in all countries with a high standard of living. An increase in the incidence of asymptomatic…
Atrial fibrillation (AF) is the most common serious heart rhythm disorder and a common cause of ischemic stroke. Arterial hypertension (AH) is known to be one of the risk factors leading to the development of AF…
The aim of the study was to study the features of the clinical course of acute obstructive bronchitis in frequently ill children in order to improve therapeutic measures. Our studies have shown that the drug…
Broncho-pulmonary diseases in children is one of the urgent problems in pediatrics, which is determined by the continuing high incidence and severe prognosis, especially in young children. The aim of the study was to…
The aim of the study was to establish the significance of neutrophil elastase in the development of nonspecific interstitial pneumonia.Material and methods of research. As a material, we examined 140 patients with…
Chronic Obstructive Pulmonary Disease (COPD) is a disease of the respiratory system that develops continuously and has an increasing mortality rate. The purpose of the study is to study the characteristics of the immune…
Purpose: to evaluate indicators of psychological status, health level and physical performance in individuals with alimentary obesity (AO) and high cardiovascular risk (CVR). Material and methods. 99 individuals with…
Congenital heart defects (CHDs) are an important problem in pediatrics due to their high prevalence and the need for early surgical correction due to significant health problems and disability in children. according to…
The effects of menopause and hormone therapy on cytokine production and plasma levels are equally complex. Aging is associated with increased levels of circulating inflammatory cytokines, especially IL-6 and TNFa, a…
Purpose of the study: to determine the relationship between the levels of cytokines (IL-1β, IL-6; IL-10, TNF-α) and the clinical course of coronary artery disease in COPD. Material and methods: this study is based on…
Journal of cardiorespiratory research/Kardiorespirator tadqiqotlar jurnali — barcha maqolalar · 2023-yil arxivi
This article describes a new and improved method for assessing the effectiveness of the risk management process in analytical testing laboratories, and outlines the steps involved in its implementation. The weighting…
Objective: To study the antihypertensive efficacy of 6-month combined therapy in patients with AH after coronavirus infection Material and methods: The study included patients with I-III degree of AH (ESC/ESH 2018)…
The purpose of the study: to study the antihypertensive and vasoprotective efficacy of 3-month combined AGT with the inclusion of torasemide, as well as the tolerability of torasemide as part of combined…
Atrial fibrillation (AF) is the most common serious heart rhythm disorder and a common cause of ischemic stroke. Arterial hypertension (AH) is known to be one of the risk factors leading to the development of AF…
Настоящее исследование посвящено разработке алгоритма раннего выявления сенсоневральной тугоухости у детей с использованием методов полимеразной цепной реакции (ПЦР). Обследовано 235 детей с нарушениями слуха, из…
В статье представлены клинические аспекты и диагностические проблемы выявления сенсоневральной тугоухости у новорождённых с перинатальной патологией. Обследовано 115 новорождённых, из которых 35 перенесли асфиксию, а у…
Сенсоневральная тугоухость (СНТ) у детей остаётся одной из наиболее актуальных проблем современной оториноларингологии и медицинской генетики. Ранняя диагностика нарушений слуха играет ключевую роль в предупреждении…
Сенсоневральная тугоухость у новорождённых является одной из ведущих причин нарушения слухоречевого развития и ранней инвалидизации. Наиболее уязвимыми считаются дети, перенёсшие перинатальные осложнения, такие как…
Mazkur eksperimental tadqiqotda yuqori yog‘li ratsion va seftriaksonning lipid hamda uglevod almashinuviga alohida va birgalikdagi ta’siri 160 ta oq zotsiz erkak kalamushda o‘rganildi. Tajriba hayvonlari to‘rtta guruhga…
Мазкур тадқиқотда Тошкет вилоятидаги Ўрта Чирчиқ тумани 25-сонли, Бўка тумани 3-сонли ва 9-сонли давлат мактабгача таълим ташкилотларида 2025 йил ёз мавсумидаги таомномаларнинг озиқ-овқат маҳсулотлари билан…