Characteristics of the immune reaction in chronic obstructive pulmonary disease phenotypes

Насирова Азиза Акбаровна

Journal of cardiorespiratory research/Kardiorespirator tadqiqotlar jurnali · 2023-yil

Annotatsiya

Chronic Obstructive Pulmonary Disease (COPD) is a disease of the respiratory system that develops continuously and has an increasing mortality rate. The purpose of the study is to study the characteristics of the immune response in the clinical and functional phenotypes of COPD. Materials and methods. A prospective comparative study included 75 patients (mean age 54.3 ± 3.6 years) with stable COPD on the basis of voluntary patient consent. COPD diagnosis Global Initiative for Chronic Obstructive Lung Disease: Global strategy for the diagnosis, treatment and prevention of Chronic Obstructive Lung Disease (GOLD, 2021). was carried out according to the criteria. Among those examined, 25 patients with a mild course (COPD 1st), 31 – with a medium-severe course (COPD 2nd), and 19 – with a severe course (COPD 3rd). there were patients. The control group consisted of 20 healthy non-smoking volunteers (mean age 51.0±3.2). Results. Various types of immunity have been identified in the inflammatory response in patients with COPD. The analysis of the cytokine profile in the observation groups showed that in patients with a bronchitic phenotype (group 1) in 63% of cases, TNF was 2.3 times lower against the background of a 1.2-fold (p < 0.05) decrease in the level of IL-4 compared to the control group (p < 0.05) and IFN increased 2.5-fold (p < 0.05). An increase in the anti-inflammatory cytokine IFN and a decrease in the IFN/IL-17A ratio of IL-4 in some patients with COPD with a bronchitic phenotype indicate the activation of the inflammatory process in patients.

Maqola ma’lumotlari
MualliflarНасирова Азиза Акбаровна
JurnalJournal of cardiorespiratory research/Kardiorespirator tadqiqotlar jurnali
NashriyotСамарқанд давлат тиббиёт университети
Nashr sanasi2023-06-12
Jild4
Son1
TilIngliz
Ilmiy sohaTibbiyot
Indeksga qo‘shilgan2026-08-26

Maqolaning asl sahifasi

Kalit so‘zlar

хроническая обструктивная болезн легких, интерлейкин, Т-хелперы, объем форсированного выдыхаемого воздуха, Chronic obstructive pulmonary disease, interleukin, T-helper, forced exhaled air volume., Surunkali obstruktiv o'pka kasalligi, interleykin, T-helper, majburiy chiqarilgan havo hajmi

Ilmiy soha

Tibbiyot

Iqtibos keltirish

APAНасирова Азиза Акбаровна (2023). CHARACTERISTICS OF THE IMMUNE REACTION IN CHRONIC OBSTRUCTIVE PULMONARY DISEASE PHENOTYPES. Journal of cardiorespiratory research/Kardiorespirator tadqiqotlar jurnali, 4(1). https://www.tadqiqot.uz/index.php/cardio/article/view/7447
GOST (OAK)Насирова Азиза Акбаровна CHARACTERISTICS OF THE IMMUNE REACTION IN CHRONIC OBSTRUCTIVE PULMONARY DISEASE PHENOTYPES // Journal of cardiorespiratory research/Kardiorespirator tadqiqotlar jurnali. – 2023. – T. 4, № 1.
MLAНасирова Азиза Акбаровна. “CHARACTERISTICS OF THE IMMUNE REACTION IN CHRONIC OBSTRUCTIVE PULMONARY DISEASE PHENOTYPES.” Journal of cardiorespiratory research/Kardiorespirator tadqiqotlar jurnali, 4(1), 2023. https://www.tadqiqot.uz/index.php/cardio/article/view/7447
ChicagoНасирова Азиза Акбаровна. “CHARACTERISTICS OF THE IMMUNE REACTION IN CHRONIC OBSTRUCTIVE PULMONARY DISEASE PHENOTYPES.” Journal of cardiorespiratory research/Kardiorespirator tadqiqotlar jurnali, 4(1) (2023). https://www.tadqiqot.uz/index.php/cardio/article/view/7447
HarvardНасирова Азиза Акбаровна (2023) ‘CHARACTERISTICS OF THE IMMUNE REACTION IN CHRONIC OBSTRUCTIVE PULMONARY DISEASE PHENOTYPES’, Journal of cardiorespiratory research/Kardiorespirator tadqiqotlar jurnali, 4(1). https://www.tadqiqot.uz/index.php/cardio/article/view/7447
BibTeX
@article{article2023,
  title = {CHARACTERISTICS OF THE IMMUNE REACTION IN CHRONIC OBSTRUCTIVE PULMONARY DISEASE PHENOTYPES},
  author = {Насирова Азиза Акбаровна},
  journal = {Journal of cardiorespiratory research/Kardiorespirator tadqiqotlar jurnali},
  year = {2023},
  volume = {4},
  number = {1},
  url = {https://www.tadqiqot.uz/index.php/cardio/article/view/7447}
}

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