Regioselective acylation of 2-AMINO-6-OXOPURINE: synthesis, reaction conditions and structural characterization

Oripov, Oybek Bekboyevich, Xalilov, Sodiqjon Shokir o'g'li, Oxunov Islomovich, Isroil, Saitkulov, Foziljon Ergashevich, Mirvaliyev, Zoid Zohidovich

Қўқон ДПИ. Илмий хабарлар · 2026-yil

Annotatsiya

This study investigates the acylation reactions of 2-amino-6-oxopurine with different acylating agents and evaluates the influence of reaction conditions on product formation and yield. Acylation was carried out using acetic anhydride, acetyl chloride, propionic anhydride, benzoyl chloride, and succinic anhydride in appropriate organic media. The effects of the nature of the acylating reagent, solvent, temperature, reaction time, and reagent ratio on the efficiency and selectivity of the reactions were examined. Particular attention was paid to the reactivity of the exocyclic 2-amino group and other potential reaction centers of the purine system. The structures of the synthesized derivatives were characterized using FTIR, NMR, and other physicochemical methods. Comparative analysis showed that the type of acylating agent and reaction medium significantly affected conversion and product yield. Among the investigated conditions, acetic anhydride provided particularly favorable acylation efficiency. The obtained results provide a basis for developing optimized methods for the synthesis of functionalized 2-amino-6-oxopurine derivatives and for their further investigation as potentially biologically active compounds.

Maqola ma’lumotlari
MualliflarOripov, Oybek Bekboyevich, Xalilov, Sodiqjon Shokir o'g'li, Oxunov Islomovich, Isroil, Saitkulov, Foziljon Ergashevich, Mirvaliyev, Zoid Zohidovich
JurnalҚўқон ДПИ. Илмий хабарлар
NashriyotҚўқон давлат педагогика институти
ISSN3030-3958
Nashr sanasi2026-10-10
Jild8
Son9
Betlar1098-1108
TilIngliz
DOI10.70728/a.series.tab.v08.i09.144
Indeksga qo‘shilgan2026-10-11

DOI: 10.70728/a.series.tab.v08.i09.144 · Maqolaning asl sahifasi

Kalit so‘zlar

2-amino-6-oxopurine, acylation, acetic anhydride, acetyl chloride, purine derivatives, regioselectivity, synthesis.

Iqtibos keltirish

APAOripov, Oybek Bekboyevich, Xalilov, Sodiqjon Shokir o'g'li, Oxunov Islomovich, Isroil, Saitkulov, Foziljon Ergashevich, & Mirvaliyev, Zoid Zohidovich (2026). REGIOSELECTIVE ACYLATION OF 2-AMINO-6-OXOPURINE: SYNTHESIS, REACTION CONDITIONS AND STRUCTURAL CHARACTERIZATION. Қўқон ДПИ. Илмий хабарлар, 8(9), 1098-1108. https://doi.org/10.70728/a.series.tab.v08.i09.144
GOST (OAK)Oripov, Oybek Bekboyevich va b. REGIOSELECTIVE ACYLATION OF 2-AMINO-6-OXOPURINE: SYNTHESIS, REACTION CONDITIONS AND STRUCTURAL CHARACTERIZATION // Қўқон ДПИ. Илмий хабарлар. – 2026. – T. 8, № 9. – P. 1098-1108. – DOI: 10.70728/a.series.tab.v08.i09.144.
MLAOripov, Oybek Bekboyevich, Xalilov, Sodiqjon Shokir o'g'li, Oxunov Islomovich, Isroil, Saitkulov, Foziljon Ergashevich, and Mirvaliyev, Zoid Zohidovich. “REGIOSELECTIVE ACYLATION OF 2-AMINO-6-OXOPURINE: SYNTHESIS, REACTION CONDITIONS AND STRUCTURAL CHARACTERIZATION.” Қўқон ДПИ. Илмий хабарлар, 8(9), 1098-1108, 2026. https://doi.org/10.70728/a.series.tab.v08.i09.144
ChicagoOripov, Oybek Bekboyevich, Xalilov, Sodiqjon Shokir o'g'li, Oxunov Islomovich, Isroil, Saitkulov, Foziljon Ergashevich, and Mirvaliyev, Zoid Zohidovich. “REGIOSELECTIVE ACYLATION OF 2-AMINO-6-OXOPURINE: SYNTHESIS, REACTION CONDITIONS AND STRUCTURAL CHARACTERIZATION.” Қўқон ДПИ. Илмий хабарлар, 8(9), 1098-1108 (2026). https://doi.org/10.70728/a.series.tab.v08.i09.144
HarvardOripov, Oybek Bekboyevich, Xalilov, Sodiqjon Shokir o'g'li, Oxunov Islomovich, Isroil, Saitkulov, Foziljon Ergashevich, and Mirvaliyev, Zoid Zohidovich (2026) ‘REGIOSELECTIVE ACYLATION OF 2-AMINO-6-OXOPURINE: SYNTHESIS, REACTION CONDITIONS AND STRUCTURAL CHARACTERIZATION’, Қўқон ДПИ. Илмий хабарлар, 8(9), 1098-1108. https://doi.org/10.70728/a.series.tab.v08.i09.144
BibTeX
@article{oripovoybekbekboyevich2026,
  title = {REGIOSELECTIVE ACYLATION OF 2-AMINO-6-OXOPURINE: SYNTHESIS, REACTION CONDITIONS AND STRUCTURAL CHARACTERIZATION},
  author = {Oripov, Oybek Bekboyevich and Xalilov, Sodiqjon Shokir o'g'li and Oxunov Islomovich, Isroil and Saitkulov, Foziljon Ergashevich and Mirvaliyev, Zoid Zohidovich},
  journal = {Қўқон ДПИ. Илмий хабарлар},
  year = {2026},
  volume = {8},
  number = {9},
  pages = {1098-1108},
  doi = {10.70728/a.series.tab.v08.i09.144},
  url = {https://doi.org/10.70728/a.series.tab.v08.i09.144}
}

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