An integrated TGF-β1 and CYP2E1 genetic index for predicting severe liver cirrhosis

J.B. Ravzatov, D.A. Nabiyeva

Zamonaviy tibbiyot jurnali / Journal of modern medicine · 2026-yil

Annotatsiya

This study evaluated the association between an integrated genetic index based on the TGF-β1 CT+TT and CYP2E1 c1/c2+c2/c2 risk genotypes and the clinical severity and unfavorable course of liver cirrhosis. The study included 180 patients with liver cirrhosis of various etiologies. According to the genetic index, the patients were classified into low-, intermediate-, and high-risk groups. Low, intermediate, and high genetic risk was identified in 28.3%, 52.2%, and 19.5% of patients, respectively. Increasing genetic risk was accompanied by a consistent rise in the frequency of Child–Pugh class C, ascites, and hepatic encephalopathy. The MELD/MELD-Na score increased from 13.9±4.0 to 19.2±5.0 points, whereas serum albumin decreased from 34.0±5.4 to 27.5±6.2 g/L. The genetic index showed positive correlations with Child–Pugh, MELD/MELD-Na, and total bilirubin and negative correlations with serum albumin and the SF-36 physical component score. A high genetic index was significantly associated with severe liver cirrhosis, with an odds ratio of 3.26. The findings indicate that the combined assessment of TGF-β1 and CYP2E1 genetic variants together with clinical and laboratory parameters may improve individualized risk stratification and prediction of an unfavorable course of liver cirrhosis. Purpose – to evaluate the association of an integrated genetic index incorporating the TGF-β1 CT+TT and CYP2E1 c1/c2+c2/c2 risk genotypes with the severity and adverse course of liver cirrhosis. Material and methods – The analysis included 180 patients with liver cirrhosis of various etiologies. The index was scored from 0 to 2: no risk genotype, 0; one risk genotype, 1; and both risk genotypes, 2. Disease severity was assessed using Child–Pugh, MELD/MELD-Na, ascites, hepatic encephalopathy, serum albumin, and the SF-36 physical component score. The χ² test, Spearman correlation, and logistic regression were applied. Results – Low, intermediate, and high genetic risk was observed in 28.3%, 52.2%, and 19.5% of patients, respectively. Across increasing risk categories, Child–Pugh class C rose from 13.7% to 40.0%, ascites from 37.3% to 71.4%, and encephalopathy from 15.7% to 40.0%. MELD/MELD-Na increased from 13.9±4.0 to 19.2±5.0, whereas albumin decreased from 34.0±5.4 to 27.5±6.2 g/L. High genetic risk was associated with severe disease (OR=3.26; 95% CI: 1.48–7.19; p<0.01), while albumin <30 g/L showed the largest clinical effect (OR=3.72). Conclusion – Combining the TGF-β1/CYP2E1 genetic index with clinical and functional variables may improve individualized risk stratification; however, internal and external validation is required.

Maqola ma’lumotlari
MualliflarJ.B. Ravzatov, D.A. Nabiyeva
JurnalZamonaviy tibbiyot jurnali / Journal of modern medicine
NashriyotАндижон давлат тиббиёт институти
ISSN2992-8958
Nashr sanasi2026-07-23
Jild14
Son3
Betlar303-310
TilIngliz
Ilmiy sohaTibbiyot
DOI10.67519/nshr.ztj.2026.03.083
Indeksga qo‘shilgan2026-09-02

DOI: 10.67519/nshr.ztj.2026.03.083 · Maqolaning asl sahifasi · PDF

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APAJ.B. Ravzatov, & D.A. Nabiyeva (2026). AN INTEGRATED TGF-β1 AND CYP2E1 GENETIC INDEX FOR PREDICTING SEVERE LIVER CIRRHOSIS. Zamonaviy tibbiyot jurnali / Journal of modern medicine, 14(3), 303-310. https://doi.org/10.67519/nshr.ztj.2026.03.083
GOST (OAK)J.B. Ravzatov, D.A. Nabiyeva AN INTEGRATED TGF-β1 AND CYP2E1 GENETIC INDEX FOR PREDICTING SEVERE LIVER CIRRHOSIS // Zamonaviy tibbiyot jurnali / Journal of modern medicine. – 2026. – T. 14, № 3. – P. 303-310. – DOI: 10.67519/nshr.ztj.2026.03.083.
MLAJ.B. Ravzatov, and D.A. Nabiyeva. “AN INTEGRATED TGF-β1 AND CYP2E1 GENETIC INDEX FOR PREDICTING SEVERE LIVER CIRRHOSIS.” Zamonaviy tibbiyot jurnali / Journal of modern medicine, 14(3), 303-310, 2026. https://doi.org/10.67519/nshr.ztj.2026.03.083
ChicagoJ.B. Ravzatov, and D.A. Nabiyeva. “AN INTEGRATED TGF-β1 AND CYP2E1 GENETIC INDEX FOR PREDICTING SEVERE LIVER CIRRHOSIS.” Zamonaviy tibbiyot jurnali / Journal of modern medicine, 14(3), 303-310 (2026). https://doi.org/10.67519/nshr.ztj.2026.03.083
HarvardJ.B. Ravzatov, and D.A. Nabiyeva (2026) ‘AN INTEGRATED TGF-β1 AND CYP2E1 GENETIC INDEX FOR PREDICTING SEVERE LIVER CIRRHOSIS’, Zamonaviy tibbiyot jurnali / Journal of modern medicine, 14(3), 303-310. https://doi.org/10.67519/nshr.ztj.2026.03.083
BibTeX
@article{jbravzatov2026,
  title = {AN INTEGRATED TGF-β1 AND CYP2E1 GENETIC INDEX FOR PREDICTING SEVERE LIVER CIRRHOSIS},
  author = {J.B. Ravzatov and D.A. Nabiyeva},
  journal = {Zamonaviy tibbiyot jurnali / Journal of modern medicine},
  year = {2026},
  volume = {14},
  number = {3},
  pages = {303-310},
  doi = {10.67519/nshr.ztj.2026.03.083},
  url = {https://doi.org/10.67519/nshr.ztj.2026.03.083}
}

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