The effect of chronic lead intoxication on bone tissue metabolism and osteoreparation: experimental rationale for combined corrective therapy

E.Iu. Valiev, Д.О. Эргашев, О.Э. Валиев, А.Т. Эрметов, Х.А. Тиляков, N.O. Suvonov

Zamonaviy tibbiyot jurnali / Journal of modern medicine · 2026-yil

Annotatsiya

Background. Lead is one of the most osteotropic toxicants: up to 90% of the total body burden is deposited within the bone mineral matrix, where it competitively substitutes for Ca2+ in the hydroxyapatite lattice, suppresses osteoblast differentiation and enhances osteoclastogenesis. A pathogenetically grounded correction scheme for lead-induced bone metabolic disturbances, and its relationship to reparative osteogenesis, remain insufficiently studied. Aim — to experimentally assess biochemical bone metabolism markers and reparative osteogenesis under chronic lead intoxication, and to evaluate the efficacy of combined corrective therapy (vitamin D3 + calcium citrate + succinic acid). Materials and methods. Forty-five rats were allocated to three groups (control, Pb-intoxication, Pb-intoxication + correction). Chronic intoxication was induced by lead acetate administered ad libitum via drinking water for 8 weeks; at week 4 a monocortical femoral defect was created in all animals. Serum biochemical markers and cortical bone lead content (ICP-OES) were assessed. Results. The Pb group showed significantly reduced osteoblastic activity (alkaline phosphatase −39%, osteocalcin −54%), hypocalcemia (−25%) and marked bone lead accumulation (244.1±21.0 µg/g). Corrective therapy reduced bone lead deposition by 62% and produced statistically significant partial recovery of the studied biochemical parameters. Conclusion. Chronic lead intoxication produces a complex osteotoxic syndrome with disturbed biochemical markers of reparative osteogenesis; the proposed corrective regimen is pathogenetically justified and may serve as a basis for further clinical development of osteoprotective protocols.

Maqola ma’lumotlari
MualliflarE.Iu. Valiev, Д.О. Эргашев, О.Э. Валиев, А.Т. Эрметов, Х.А. Тиляков, N.O. Suvonov
JurnalZamonaviy tibbiyot jurnali / Journal of modern medicine
NashriyotАндижон давлат тиббиёт институти
ISSN2992-8958
Nashr sanasi2026-07-31
Jild14
Son3
Betlar227-234
TilIngliz
Ilmiy sohaTibbiyot
DOI10.67519/nshr.ztj.2026.03.071
Indeksga qo‘shilgan2026-09-02

DOI: 10.67519/nshr.ztj.2026.03.071 · Maqolaning asl sahifasi

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Iqtibos keltirish

APAE.Iu. Valiev, Д.О. Эргашев, О.Э. Валиев, А.Т. Эрметов, Х.А. Тиляков, & N.O. Suvonov (2026). THE EFFECT OF CHRONIC LEAD INTOXICATION ON BONE TISSUE METABOLISM AND OSTEOREPARATION: EXPERIMENTAL RATIONALE FOR COMBINED CORRECTIVE THERAPY. Zamonaviy tibbiyot jurnali / Journal of modern medicine, 14(3), 227-234. https://doi.org/10.67519/nshr.ztj.2026.03.071
GOST (OAK)E.Iu. Valiev va b. THE EFFECT OF CHRONIC LEAD INTOXICATION ON BONE TISSUE METABOLISM AND OSTEOREPARATION: EXPERIMENTAL RATIONALE FOR COMBINED CORRECTIVE THERAPY // Zamonaviy tibbiyot jurnali / Journal of modern medicine. – 2026. – T. 14, № 3. – P. 227-234. – DOI: 10.67519/nshr.ztj.2026.03.071.
MLAE.Iu. Valiev, Д.О. Эргашев, О.Э. Валиев, А.Т. Эрметов, Х.А. Тиляков, and N.O. Suvonov. “THE EFFECT OF CHRONIC LEAD INTOXICATION ON BONE TISSUE METABOLISM AND OSTEOREPARATION: EXPERIMENTAL RATIONALE FOR COMBINED CORRECTIVE THERAPY.” Zamonaviy tibbiyot jurnali / Journal of modern medicine, 14(3), 227-234, 2026. https://doi.org/10.67519/nshr.ztj.2026.03.071
ChicagoE.Iu. Valiev, Д.О. Эргашев, О.Э. Валиев, А.Т. Эрметов, Х.А. Тиляков, and N.O. Suvonov. “THE EFFECT OF CHRONIC LEAD INTOXICATION ON BONE TISSUE METABOLISM AND OSTEOREPARATION: EXPERIMENTAL RATIONALE FOR COMBINED CORRECTIVE THERAPY.” Zamonaviy tibbiyot jurnali / Journal of modern medicine, 14(3), 227-234 (2026). https://doi.org/10.67519/nshr.ztj.2026.03.071
HarvardE.Iu. Valiev, Д.О. Эргашев, О.Э. Валиев, А.Т. Эрметов, Х.А. Тиляков, and N.O. Suvonov (2026) ‘THE EFFECT OF CHRONIC LEAD INTOXICATION ON BONE TISSUE METABOLISM AND OSTEOREPARATION: EXPERIMENTAL RATIONALE FOR COMBINED CORRECTIVE THERAPY’, Zamonaviy tibbiyot jurnali / Journal of modern medicine, 14(3), 227-234. https://doi.org/10.67519/nshr.ztj.2026.03.071
BibTeX
@article{eiuvaliev2026,
  title = {THE EFFECT OF CHRONIC LEAD INTOXICATION ON BONE TISSUE METABOLISM AND OSTEOREPARATION: EXPERIMENTAL RATIONALE FOR COMBINED CORRECTIVE THERAPY},
  author = {E.Iu. Valiev and Д.О. Эргашев and О.Э. Валиев and А.Т. Эрметов and Х.А. Тиляков and N.O. Suvonov},
  journal = {Zamonaviy tibbiyot jurnali / Journal of modern medicine},
  year = {2026},
  volume = {14},
  number = {3},
  pages = {227-234},
  doi = {10.67519/nshr.ztj.2026.03.071},
  url = {https://doi.org/10.67519/nshr.ztj.2026.03.071}
}

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