The state and significance of gut microbiota in breast cancer

N. B. (N) Asatova, M.A. Abdujalilova, M.O. Saidqulova

Zamonaviy tibbiyot jurnali / Journal of modern medicine · 2026-yil

Annotatsiya

This article reviews the structural and functional state of the gut microbiota in breast cancer patients, along with its diagnostic and prognostic significance, based on current literature. Given the rising incidence, including in Uzbekistan, and the inability of traditional risk factors to explain all cases, gut microbiota dysbiosis is discussed as a novel pathogenetic factor. Key dysbiotic changes – a decreased Firmicutes/Bacteroidetes ratio, reduced butyrate-producing Faecalibacterium prausnitzii and Bifidobacterium, and increased Fusobacterium nucleatum, Bacteroides fragilis, Escherichia coli – are analyzed in relation to molecular subtype and disease stage. The potential of using microbiota composition and metabolites (e.g., butyrate, kynurenine) as non-invasive biomarkers for early diagnosis, prognosis, and therapy response prediction is examined. Therapeutically, evidence on the efficacy of probiotics, prebiotics, and synbiotics in reducing chemotherapy-related diarrhea and fatigue, improving endocrine therapy outcomes by lowering β‑glucuronidase activity, and the use of fecal microbiota transplantation in immunotherapy-resistant cases is presented. The importance of a high-fiber diet and fermented foods in risk reduction through microbiota modulation is also discussed. The need for systematic microbiota-based research in Uzbekistan is substantiated.

Maqola ma’lumotlari
MualliflarN. B. (N) Asatova, M.A. Abdujalilova, M.O. Saidqulova
JurnalZamonaviy tibbiyot jurnali / Journal of modern medicine
NashriyotАндижон давлат тиббиёт институти
ISSN2992-8958
Nashr sanasi2026-08-06
Jild14
Son3
Betlar543-557
TilIngliz
Ilmiy sohaTibbiyot
DOI10.67519/nshr.ztj.2026.03.011
Indeksga qo‘shilgan2026-09-02

DOI: 10.67519/nshr.ztj.2026.03.011 · Maqolaning asl sahifasi · PDF

Ilmiy soha

Tibbiyot

Iqtibos keltirish

APAN. B. (N) Asatova, M.A. Abdujalilova, & M.O. Saidqulova (2026). THE STATE AND SIGNIFICANCE OF GUT MICROBIOTA IN BREAST CANCER. Zamonaviy tibbiyot jurnali / Journal of modern medicine, 14(3), 543-557. https://doi.org/10.67519/nshr.ztj.2026.03.011
GOST (OAK)N. B. (N) Asatova, M.A. Abdujalilova, M.O. Saidqulova THE STATE AND SIGNIFICANCE OF GUT MICROBIOTA IN BREAST CANCER // Zamonaviy tibbiyot jurnali / Journal of modern medicine. – 2026. – T. 14, № 3. – P. 543-557. – DOI: 10.67519/nshr.ztj.2026.03.011.
MLAN. B. (N) Asatova, M.A. Abdujalilova, and M.O. Saidqulova. “THE STATE AND SIGNIFICANCE OF GUT MICROBIOTA IN BREAST CANCER.” Zamonaviy tibbiyot jurnali / Journal of modern medicine, 14(3), 543-557, 2026. https://doi.org/10.67519/nshr.ztj.2026.03.011
ChicagoN. B. (N) Asatova, M.A. Abdujalilova, and M.O. Saidqulova. “THE STATE AND SIGNIFICANCE OF GUT MICROBIOTA IN BREAST CANCER.” Zamonaviy tibbiyot jurnali / Journal of modern medicine, 14(3), 543-557 (2026). https://doi.org/10.67519/nshr.ztj.2026.03.011
HarvardN. B. (N) Asatova, M.A. Abdujalilova, and M.O. Saidqulova (2026) ‘THE STATE AND SIGNIFICANCE OF GUT MICROBIOTA IN BREAST CANCER’, Zamonaviy tibbiyot jurnali / Journal of modern medicine, 14(3), 543-557. https://doi.org/10.67519/nshr.ztj.2026.03.011
BibTeX
@article{nbnasatova2026,
  title = {THE STATE AND SIGNIFICANCE OF GUT MICROBIOTA IN BREAST CANCER},
  author = {N. B. (N) Asatova and M.A. Abdujalilova and M.O. Saidqulova},
  journal = {Zamonaviy tibbiyot jurnali / Journal of modern medicine},
  year = {2026},
  volume = {14},
  number = {3},
  pages = {543-557},
  doi = {10.67519/nshr.ztj.2026.03.011},
  url = {https://doi.org/10.67519/nshr.ztj.2026.03.011}
}

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