This article reviews the structural and functional state of the gut microbiota in breast cancer patients, along with its diagnostic and prognostic significance, based on current literature. Given the rising incidence, including in Uzbekistan, and the inability of traditional risk factors to explain all cases, gut microbiota dysbiosis is discussed as a novel pathogenetic factor. Key dysbiotic changes – a decreased Firmicutes/Bacteroidetes ratio, reduced butyrate-producing Faecalibacterium prausnitzii and Bifidobacterium, and increased Fusobacterium nucleatum, Bacteroides fragilis, Escherichia coli – are analyzed in relation to molecular subtype and disease stage. The potential of using microbiota composition and metabolites (e.g., butyrate, kynurenine) as non-invasive biomarkers for early diagnosis, prognosis, and therapy response prediction is examined. Therapeutically, evidence on the efficacy of probiotics, prebiotics, and synbiotics in reducing chemotherapy-related diarrhea and fatigue, improving endocrine therapy outcomes by lowering β‑glucuronidase activity, and the use of fecal microbiota transplantation in immunotherapy-resistant cases is presented. The importance of a high-fiber diet and fermented foods in risk reduction through microbiota modulation is also discussed. The need for systematic microbiota-based research in Uzbekistan is substantiated.
| Mualliflar | N. B. (N) Asatova, M.A. Abdujalilova, M.O. Saidqulova |
|---|---|
| Jurnal | Zamonaviy tibbiyot jurnali / Journal of modern medicine |
| Nashr sanasi | 2026-08-06 |
| Jild | 14 |
| Son | 3 |
| Betlar | 543-557 |
| Til | en |
| DOI | 10.67519/nshr.ztj.2026.03.011 |
DOI: 10.67519/nshr.ztj.2026.03.011 · Maqolaning asl sahifasi · PDF
Psychoemotional disorders have reached epidemic-level indicators globally, affecting 13-14% of the world's population. This article examines the mechanisms by which neurogenic factors - the HPA axis, neurotransmitter…
This article presents results of a multivariate analysis based on clinical, laboratory, and instrumental examination data of 94 patients with bladder exstrophy who were treated at the Urology Department of the National…
The article examines the clinical and morphological features of dry eye syndrome and neuropathic ocular pain after LASIK surgery. The study included 60 patients, or 120 eyes, divided into four groups according to…
Breast cancer remains the leading oncological disease among women in Uzbekistan, with 4,454 new cases and 2,067 deaths recorded in 2020 alone. This article provides a scientific analysis of mammographic screening…
Chronic carbon monoxide exposure induces persistent tissue hypoxia, resulting in structural remodeling of the kidney. The severity of renal injury largely depends on age-related adaptive capacity of the nephron. The…
SARS-CoV-2 is the viral causative agent of COVID-19, the disease that led to the pandemic that emerged in 2019. Although this disease is primarily classified as a respiratory tract infection, patients with COVID-19 may…
Chronic carbon monoxide exposure induces persistent tissue hypoxia, resulting in structural remodeling of the kidney. The severity of renal injury largely depends on age-related adaptive capacity of the nephron. The…
Combined surgical interventions have become an integral component of modern gynecological practice due to advances in minimally invasive surgery, improved anesthetic techniques, and multidisciplinary patient…
The study was conducted on 120 male albino rats with chronic pancreatitis induced by two intraperitoneal injections of L-arginine. Serum GLP-1, GIP, and insulin concentrations were determined by enzyme-linked…
This article examines the diagnostic and prognostic significance of urinary neutrophil gelatinase-associated lipocalin (uNGAL), β2-microglobulin, and endothelin-1 as emerging biomarkers in the development and…
Zamonaviy tibbiyot jurnali / Journal of modern medicine — barcha maqolalar