Pathogenetic aspects of acute pancreatitis at the sub-cellular level

А.М. ХАДЖИБАЕВ, М.Д. УРАЗМЕТОВА, Ф.А. ХАДЖИБАЕВ, А.Г. МИРЗАКУЛОВ

Shoshilinch tibbiyot axborotnomasi · 2023-yil

Annotatsiya

The pathogenesis of acute pancreatitis (AP) is based on a cascade of reactions of immunologicalinflammation due to dysfunction of important structures at the subcellular level. At an early stage of AP,excessive activation of leukocytes and the subsequent release of an inflammatory mediator are crucial forthe development of early organ failure. Regardless of the cause, trigger events lead to premature activationof pancreatic proteases simultaneously with the activation of lysosomal enzymes. The initiating events ofpancreatic necrosis, including zymogen activation and cell death, occur in the pancreatic acinar cells (PAC),where the earliest immune response is also noted in the form of activation of circulating immune cells,which triggers a systemic inflammatory response. Further in-depth study of pathophysiological disordersat the subcellular level is necessary for targeted and effective therapy of AP.

Maqola ma’lumotlari
MualliflarА.М. ХАДЖИБАЕВ, М.Д. УРАЗМЕТОВА, Ф.А. ХАДЖИБАЕВ, А.Г. МИРЗАКУЛОВ
JurnalShoshilinch tibbiyot axborotnomasi
NashriyotЎзбекистон шошилинч тиббий ёрдам врачлари, ассоциацияси
ISSN2010-9881
Nashr sanasi2023-01-01
Jild15
Son5
TilIngliz
Ilmiy sohaTibbiyot
DOI10.54185/tbem/vol15_iss5/a11
Indeksga qo‘shilgan2026-09-02

DOI: 10.54185/tbem/vol15_iss5/a11 · Maqolaning asl sahifasi · PDF

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APAА.М. ХАДЖИБАЕВ, М.Д. УРАЗМЕТОВА, Ф.А. ХАДЖИБАЕВ, & А.Г. МИРЗАКУЛОВ (2023). Pathogenetic aspects of acute pancreatitis at the sub-cellular level. Shoshilinch tibbiyot axborotnomasi, 15(5). https://doi.org/10.54185/tbem/vol15_iss5/a11
GOST (OAK)А.М. ХАДЖИБАЕВ va b. Pathogenetic aspects of acute pancreatitis at the sub-cellular level // Shoshilinch tibbiyot axborotnomasi. – 2023. – T. 15, № 5. – DOI: 10.54185/tbem/vol15_iss5/a11.
MLAА.М. ХАДЖИБАЕВ, М.Д. УРАЗМЕТОВА, Ф.А. ХАДЖИБАЕВ, and А.Г. МИРЗАКУЛОВ. “Pathogenetic aspects of acute pancreatitis at the sub-cellular level.” Shoshilinch tibbiyot axborotnomasi, 15(5), 2023. https://doi.org/10.54185/tbem/vol15_iss5/a11
ChicagoА.М. ХАДЖИБАЕВ, М.Д. УРАЗМЕТОВА, Ф.А. ХАДЖИБАЕВ, and А.Г. МИРЗАКУЛОВ. “Pathogenetic aspects of acute pancreatitis at the sub-cellular level.” Shoshilinch tibbiyot axborotnomasi, 15(5) (2023). https://doi.org/10.54185/tbem/vol15_iss5/a11
HarvardА.М. ХАДЖИБАЕВ, М.Д. УРАЗМЕТОВА, Ф.А. ХАДЖИБАЕВ, and А.Г. МИРЗАКУЛОВ (2023) ‘Pathogenetic aspects of acute pancreatitis at the sub-cellular level’, Shoshilinch tibbiyot axborotnomasi, 15(5). https://doi.org/10.54185/tbem/vol15_iss5/a11
BibTeX
@article{article2023,
  title = {Pathogenetic aspects of acute pancreatitis at the sub-cellular level},
  author = {А.М. ХАДЖИБАЕВ and М.Д. УРАЗМЕТОВА and Ф.А. ХАДЖИБАЕВ and А.Г. МИРЗАКУЛОВ},
  journal = {Shoshilinch tibbiyot axborotnomasi},
  year = {2023},
  volume = {15},
  number = {5},
  doi = {10.54185/tbem/vol15_iss5/a11},
  url = {https://doi.org/10.54185/tbem/vol15_iss5/a11}
}

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