Background: Herpesviruses infection especially Cytomegalovirus (CMV) in transplant recipients cause life-threatening diseases. Furthermore, their management may be complicated by co-infection with other human herpes viruses like Epstein-Barr Virus (EBV) and human herpes virus 6 (HHV6). Besides CMV, no data is available for EBV and HHV6 in transplant recipients in the country. Study Population: The study included 48 renal transplant recipients, and 36 allogenic hematopoietic stem cell transplant (allo-HSCT) recipients treated at Evercare Hospital in Dhaka, Bangladesh, between February 2015 and November 2023. Materials and method: The transplant recipients were advised to undergo CMV, EBV, and HHV6 PCR tests based on recommendations from nephrologists and hematologists. The diagnostic method used was multiplex real-time PCR, which allows for the simultaneous detection of multiple pathogens in a single test. Results: In renal transplant recipients, 43.75% tested positive for herpesvirus infections. Among them, 35.42% had CMV as the sole infection, while 8.33% had co-infections involving CMV, EBV, and HHV6. In allo-HSCT recipients, 88.89% tested positive for herpesvirus infections. Of these, 58.33% had CMV as the only infection, 11.11% had HHV6, and 19.45% had co-infections with CMV, EBV, and HHV6. Interestingly, no cases of EBV infection as a single pathogen were found in either group of patients. Thus, this study suggests that after renal and allo-HSCT transplant procedures, multiplex real-time PCR for CMV, EBV, and HHV6 may be valuable for the further management of these patients and warrants large scale study. Pulse Vol.16, 2024 P: 15-21
| Mualliflar | Nazmul Hasan, Rummana Rahim, A. R. Hasan, Abu Jafar Mohammad Saleh, Mizanur Rahman |
|---|---|
| Jurnal | PULSE |
| Nashr sanasi | 2024-10-21 |
| Jild | 16 |
| Son | 1 |
| Betlar | 15-21 |
| Til | en |
| DOI | 10.3329/pulse.v16i1.77065 |
DOI: 10.3329/pulse.v16i1.77065 · Maqolaning asl sahifasi · PDF
Plasma protein-C is a naturally occurring anticoagulant and its deficiency, either homozygous or heterozygous, predisposes the individual to a state of thrombosis, particularly venous thromboembolism, and manifests as…
OBJECTIVE: To determine whether or not noninvasive assessment of the cardiovascular system can discriminate white coat hypertension and hypertension in postmenopausal women. The major reason is the high prevalence of…
Surgical Site Infection (SSI) is an infection that occurs after any surgical procedure with adverse effects on a patient’s prognosis. SSIs are caused by a variety of bacteria including Non-Tuberculous Mycobacteria…
BACKGROUND: Polymorphisms of -174G/C and -572C/G in the Interleukin-6 (IL-6) promoter gene can affect both transcription and secretion of IL-6 and may be involved in the inflammatory mechanisms in early and delayed…
Background Sexually Transmitted Infections (STIs) are often diagnosed by clinical symptoms and signs due to lack of sensitive laboratory methods. Most of the time pathogens are not identified and antibiotics are used…
A chordoma is a slow-growing malignant tumour with a metastatic potential developing from notochord remnants. The incidence is about 1 % of all malignant bone tumours with a male to female ration of 1 : 1. Most patients…
Objective: We aimed to investigate the relation between CHA2DS2-VASc score and microvascular dysfunction (MVD) assessed by the index of microvascular resistance (IMR) immediately after primary percutaneous intervention…
The prevalence of hypertension in most Asian countries has been increasing in the last 30 years and more dramatically in the last 10 years. Various factors are thought to have contributed to such drastic changes in…
Severe hypertension has numerous etiologies. When accompanied by bradycardia, the spectrum of differential diagnoses is greatly narrowed and is commonly seen in patients with increased intracranial pressure. However…
The collagen vascular diseases (CVDs) include a heterogeneous group of chronic inflammatory immunologically-mediated systemic diseases, such as rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), systemic…