Detection of Human Herpes Viruses CMV, EBV, and HHV6 and their co-infection in renal and allogeneic hematopoietic stem cell transplant recipients by multiplex real-time PCR

Nazmul Hasan, Rummana Rahim, A. R. Hasan, Abu Jafar Mohammad Saleh, Mizanur Rahman

PULSE · 2024-yil

Annotatsiya

Background: Herpesviruses infection especially Cytomegalovirus (CMV) in transplant recipients cause life-threatening diseases. Furthermore, their management may be complicated by co-infection with other human herpes viruses like Epstein-Barr Virus (EBV) and human herpes virus 6 (HHV6). Besides CMV, no data is available for EBV and HHV6 in transplant recipients in the country. Study Population: The study included 48 renal transplant recipients, and 36 allogenic hematopoietic stem cell transplant (allo-HSCT) recipients treated at Evercare Hospital in Dhaka, Bangladesh, between February 2015 and November 2023. Materials and method: The transplant recipients were advised to undergo CMV, EBV, and HHV6 PCR tests based on recommendations from nephrologists and hematologists. The diagnostic method used was multiplex real-time PCR, which allows for the simultaneous detection of multiple pathogens in a single test. Results: In renal transplant recipients, 43.75% tested positive for herpesvirus infections. Among them, 35.42% had CMV as the sole infection, while 8.33% had co-infections involving CMV, EBV, and HHV6. In allo-HSCT recipients, 88.89% tested positive for herpesvirus infections. Of these, 58.33% had CMV as the only infection, 11.11% had HHV6, and 19.45% had co-infections with CMV, EBV, and HHV6. Interestingly, no cases of EBV infection as a single pathogen were found in either group of patients. Thus, this study suggests that after renal and allo-HSCT transplant procedures, multiplex real-time PCR for CMV, EBV, and HHV6 may be valuable for the further management of these patients and warrants large scale study. Pulse Vol.16, 2024 P: 15-21

Maqola ma’lumotlari
MualliflarNazmul Hasan, Rummana Rahim, A. R. Hasan, Abu Jafar Mohammad Saleh, Mizanur Rahman
JurnalPULSE
NashriyotPROFI университетининг
ISSN2074-1855, 2235-8668
Nashr sanasi2024-10-21
Jild16
Son1
Betlar15-21
TilIngliz
Ilmiy sohaPsixologiya
DOI10.3329/pulse.v16i1.77065
Indeksga qo‘shilgan2026-09-02

DOI: 10.3329/pulse.v16i1.77065 · Maqolaning asl sahifasi · PDF

Ilmiy soha

Psixologiya

Iqtibos keltirish

APANazmul Hasan, Rummana Rahim, A. R. Hasan, Abu Jafar Mohammad Saleh, & Mizanur Rahman (2024). Detection of Human Herpes Viruses CMV, EBV, and HHV6 and their co-infection in renal and allogeneic hematopoietic stem cell transplant recipients by multiplex real-time PCR. PULSE, 16(1), 15-21. https://doi.org/10.3329/pulse.v16i1.77065
GOST (OAK)Nazmul Hasan va b. Detection of Human Herpes Viruses CMV, EBV, and HHV6 and their co-infection in renal and allogeneic hematopoietic stem cell transplant recipients by multiplex real-time PCR // PULSE. – 2024. – T. 16, № 1. – P. 15-21. – DOI: 10.3329/pulse.v16i1.77065.
MLANazmul Hasan, Rummana Rahim, A. R. Hasan, Abu Jafar Mohammad Saleh, and Mizanur Rahman. “Detection of Human Herpes Viruses CMV, EBV, and HHV6 and their co-infection in renal and allogeneic hematopoietic stem cell transplant recipients by multiplex real-time PCR.” PULSE, 16(1), 15-21, 2024. https://doi.org/10.3329/pulse.v16i1.77065
ChicagoNazmul Hasan, Rummana Rahim, A. R. Hasan, Abu Jafar Mohammad Saleh, and Mizanur Rahman. “Detection of Human Herpes Viruses CMV, EBV, and HHV6 and their co-infection in renal and allogeneic hematopoietic stem cell transplant recipients by multiplex real-time PCR.” PULSE, 16(1), 15-21 (2024). https://doi.org/10.3329/pulse.v16i1.77065
HarvardNazmul Hasan, Rummana Rahim, A. R. Hasan, Abu Jafar Mohammad Saleh, and Mizanur Rahman (2024) ‘Detection of Human Herpes Viruses CMV, EBV, and HHV6 and their co-infection in renal and allogeneic hematopoietic stem cell transplant recipients by multiplex real-time PCR’, PULSE, 16(1), 15-21. https://doi.org/10.3329/pulse.v16i1.77065
BibTeX
@article{nazmulhasan2024,
  title = {Detection of Human Herpes Viruses CMV, EBV, and HHV6 and their co-infection in renal and allogeneic hematopoietic stem cell transplant recipients by multiplex real-time PCR},
  author = {Nazmul Hasan and Rummana Rahim and A. R. Hasan and Abu Jafar Mohammad Saleh and Mizanur Rahman},
  journal = {PULSE},
  year = {2024},
  volume = {16},
  number = {1},
  pages = {15-21},
  doi = {10.3329/pulse.v16i1.77065},
  url = {https://doi.org/10.3329/pulse.v16i1.77065}
}

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