Relationship between Interleukin-6 (-174G/C and -572C/G) Promoter Gene Polymorphisms and Risk of Intracerebral Hemorrhage: A Meta-Analysis

Pradeep Kumar, Shubham Misra, Arun Kumar Yadav, Amit Kumar, Mukesh K. Sriwastva, Kameshwar Prasad

PULSE · 2016-yil

Annotatsiya

BACKGROUND: Polymorphisms of -174G/C and -572C/G in the Interleukin-6 (IL-6) promoter gene can affect both transcription and secretion of IL-6 and may be involved in the inflammatory mechanisms in early and delayed phases after intracerebral hemorrhage (ICH). The role of these polymorphisms remains unclear for the pathogenesis of ICH. METHODS: PubMed, EMBASE, MEDLINE and Google Scholar searches were conducted from January 1, 1950 to February 29, 2016 and were supplemented with relevant articles identified in the references. The following search terms were used: ('interleukin-6' or 'IL-6') and ('genetic polymorphism' or 'single nucleotide polymorphisms' or 'SNP') and ('intracerebral hemorrhage' or 'ICH') and ('hemorrhagic stroke' or 'HS'). Fixed or random effects models were used to estimate the pooled odds ratios and 95% confidence intervals. Begg's funnel plot was used to assess the potential for publication bias. RESULTS: In our meta-analysis, three case-control studies involving 446 ICH cases and 2,322 controls were included. No significant association was observed for the IL-6 (-174G/C and -572C/G) gene polymorphisms with the risk of ICH under dominant, recessive and allelic models. CONCLUSION: Our meta-analysis suggests that IL-6 gene polymorphisms are not associated with the risk of ICH. However, caution must be taken while considering the results of our meta-analysis due to the presence of small sample size. Our results cannot be extrapolated to represent the effect of entire IL-6 genetic polymorphism on stroke patients worldwide. Therefore, further well-designed studies with large sample size are warranted to validate our findings and provide a profound conclusion.

Maqola ma’lumotlari
MualliflarPradeep Kumar, Shubham Misra, Arun Kumar Yadav, Amit Kumar, Mukesh K. Sriwastva, Kameshwar Prasad
JurnalPULSE
NashriyotPROFI университетининг
ISSN2074-1855, 2235-8668
Nashr sanasi2016-01-01
Jild4
Son2-3
Betlar61-68
TilIngliz
Ilmiy sohaPsixologiya
DOI10.1159/000447677
Indeksga qo‘shilgan2026-09-02

DOI: 10.1159/000447677 · Maqolaning asl sahifasi · PDF

Ilmiy soha

Psixologiya

Iqtibos keltirish

APAPradeep Kumar, Shubham Misra, Arun Kumar Yadav, Amit Kumar, Mukesh K. Sriwastva, & Kameshwar Prasad (2016). Relationship between Interleukin-6 (-174G/C and -572C/G) Promoter Gene Polymorphisms and Risk of Intracerebral Hemorrhage: A Meta-Analysis. PULSE, 4(2-3), 61-68. https://doi.org/10.1159/000447677
GOST (OAK)Pradeep Kumar va b. Relationship between Interleukin-6 (-174G/C and -572C/G) Promoter Gene Polymorphisms and Risk of Intracerebral Hemorrhage: A Meta-Analysis // PULSE. – 2016. – T. 4, № 2-3. – P. 61-68. – DOI: 10.1159/000447677.
MLAPradeep Kumar, Shubham Misra, Arun Kumar Yadav, Amit Kumar, Mukesh K. Sriwastva, and Kameshwar Prasad. “Relationship between Interleukin-6 (-174G/C and -572C/G) Promoter Gene Polymorphisms and Risk of Intracerebral Hemorrhage: A Meta-Analysis.” PULSE, 4(2-3), 61-68, 2016. https://doi.org/10.1159/000447677
ChicagoPradeep Kumar, Shubham Misra, Arun Kumar Yadav, Amit Kumar, Mukesh K. Sriwastva, and Kameshwar Prasad. “Relationship between Interleukin-6 (-174G/C and -572C/G) Promoter Gene Polymorphisms and Risk of Intracerebral Hemorrhage: A Meta-Analysis.” PULSE, 4(2-3), 61-68 (2016). https://doi.org/10.1159/000447677
HarvardPradeep Kumar, Shubham Misra, Arun Kumar Yadav, Amit Kumar, Mukesh K. Sriwastva, and Kameshwar Prasad (2016) ‘Relationship between Interleukin-6 (-174G/C and -572C/G) Promoter Gene Polymorphisms and Risk of Intracerebral Hemorrhage: A Meta-Analysis’, PULSE, 4(2-3), 61-68. https://doi.org/10.1159/000447677
BibTeX
@article{pradeepkumar2016,
  title = {Relationship between Interleukin-6 (-174G/C and -572C/G) Promoter Gene Polymorphisms and Risk of Intracerebral Hemorrhage: A Meta-Analysis},
  author = {Pradeep Kumar and Shubham Misra and Arun Kumar Yadav and Amit Kumar and Mukesh K. Sriwastva and Kameshwar Prasad},
  journal = {PULSE},
  year = {2016},
  volume = {4},
  number = {2-3},
  pages = {61-68},
  doi = {10.1159/000447677},
  url = {https://doi.org/10.1159/000447677}
}

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