Clinical Classification of Arrhythmogenic Right Ventricular Cardiomyopathy

Yu. A. Lutokhina, О. В. Благова, A. V. Nedostup, S. А. Alexandrova, A. G. Shestak, E. V. Zaklyazminskaya

PULSE · 2020-yil

Annotatsiya

Introduction: Commonly accepted clinical classification of arrhythmogenic right ventricular cardiomyopathy (ARVC) is still not developed. Objective: To study the clinical forms of ARVC. Methods: Fifty-four patients (38.7 ± 14.1 years, 42.6% men) with ARVC. Follow-up period: 21 (6–60) months. All patients underwent electrocardiography, 24 h-Holter monitoring, echocardiography, and DNA diagnostic. Magnetic resonance imaging was performed in 49 patients. Results: According to the features of clinical course of ARVC, 4 clinical forms were identified. (I) Latent arrhythmic form (n = 27) – frequent premature ventricular contractions and/or nonsustained ventricular tachycardia (VT) in the absence of sustained VT and syncope; characterized by absence of fatal arrhythmic events. (II) Manifested arrhythmic form (n = 11) – sustained VT/ventricular fibrillation; the high incidence of appropriate implantation of cardioverter-defibrillator (ICD) interventions (75%) registered. (III) ARVC with progressive chronic heart failure (CHF, n = 8) as the main manifestation of the disease; incidence of appropriate ICD interventions was 50%, mortality rate due to CHF was 25%. (IV) Combination of ARVC with left ventricular noncompaction (n = 8); characterized by mutations in desmosomal or sarcomere genes, aggressive ventricular arrhythmias, appropriate ICD interventions in 100% patients. Described 4 clinical forms are stable in time, do not transform into each other, and they are genetically determined. Conclusions: The described clinical forms of ARVC are determined by a combination of genetic and environmental factors and do not transform into each other. The proposed classification could be used in clinical practice to determine the range of diagnostic and therapeutic measures and to assess the prognosis of the disease in a particular patient.

Maqola ma’lumotlari
MualliflarYu. A. Lutokhina, О. В. Благова, A. V. Nedostup, S. А. Alexandrova, A. G. Shestak, E. V. Zaklyazminskaya
JurnalPULSE
NashriyotPROFI университетининг
ISSN2074-1855, 2235-8668
Nashr sanasi2020-01-01
Jild8
Son1-2
Betlar21-30
TilIngliz
Ilmiy sohaPsixologiya
DOI10.1159/000505652
Indeksga qo‘shilgan2026-09-02

DOI: 10.1159/000505652 · Maqolaning asl sahifasi

Ilmiy soha

Psixologiya

Iqtibos keltirish

APAYu. A. Lutokhina, О. В. Благова, A. V. Nedostup, S. А. Alexandrova, A. G. Shestak, & E. V. Zaklyazminskaya (2020). Clinical Classification of Arrhythmogenic Right Ventricular Cardiomyopathy. PULSE, 8(1-2), 21-30. https://doi.org/10.1159/000505652
GOST (OAK)Yu. A. Lutokhina va b. Clinical Classification of Arrhythmogenic Right Ventricular Cardiomyopathy // PULSE. – 2020. – T. 8, № 1-2. – P. 21-30. – DOI: 10.1159/000505652.
MLAYu. A. Lutokhina, О. В. Благова, A. V. Nedostup, S. А. Alexandrova, A. G. Shestak, and E. V. Zaklyazminskaya. “Clinical Classification of Arrhythmogenic Right Ventricular Cardiomyopathy.” PULSE, 8(1-2), 21-30, 2020. https://doi.org/10.1159/000505652
ChicagoYu. A. Lutokhina, О. В. Благова, A. V. Nedostup, S. А. Alexandrova, A. G. Shestak, and E. V. Zaklyazminskaya. “Clinical Classification of Arrhythmogenic Right Ventricular Cardiomyopathy.” PULSE, 8(1-2), 21-30 (2020). https://doi.org/10.1159/000505652
HarvardYu. A. Lutokhina, О. В. Благова, A. V. Nedostup, S. А. Alexandrova, A. G. Shestak, and E. V. Zaklyazminskaya (2020) ‘Clinical Classification of Arrhythmogenic Right Ventricular Cardiomyopathy’, PULSE, 8(1-2), 21-30. https://doi.org/10.1159/000505652
BibTeX
@article{yualutokhina2020,
  title = {Clinical Classification of Arrhythmogenic Right Ventricular Cardiomyopathy},
  author = {Yu. A. Lutokhina and О. В. Благова and A. V. Nedostup and S. А. Alexandrova and A. G. Shestak and E. V. Zaklyazminskaya},
  journal = {PULSE},
  year = {2020},
  volume = {8},
  number = {1-2},
  pages = {21-30},
  doi = {10.1159/000505652},
  url = {https://doi.org/10.1159/000505652}
}

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