Pulse wave velocity (PWV) and cardio-ankle vascular index (CAVI) are measurements of arterial stiffness and are widely used as indices of arteriosclerosis. In Japan, brachial-ankle PWV (baPWV) is generally used to measure PWV, and while the reference value for this parameter is specified in Japanese guidelines for the noninvasive vascular function test, the CAVI reference value has not been standardized. We measured CAVI in 4,545 patients with at least one cardiovascular risk factor, and baPWV in 1,737 of these 4,545 patients on the same day as a part of an ongoing nationwide registry. The association between CAVI and baPWV was positive and significant (r = 0.50, p < 0.001). The CAVI corresponding to baPWV 14 m/s derived from the regression line was 8.303 and the CAVI corresponding to baPWV 18 m/s was 9.059. The percentages of patients with low risk (CAVI < 8.303), medium risk (CAVI 8.303–9.058) and high risk (CAVI ≥9.059) were 35.0, 23.0, and 42.0% in 4,545 patients who underwent CAVI, respectively. The percentages of patients with baPWV < 14 m/s, baPWV 14–18 m/s and baPWV ≥18 m/s were 22.9, 47.3, and 29.8% in 1,737 patients who underwent both baPWV and CAVI, respectively. The average baPWV in low-risk patients (CAVI < 8.303, n = 642) was 14.97 ± 2.91 m/s, that in medium-risk patients (CAVI 8.303–9.058, n = 408) was 16.12 ± 2.80 m/s, and that in high-risk patients (CAVI ≥9.059, n = 687) was 18.40 ± 3.51 m/s. CAVI < 8.303 corresponded to a baPWV cutoff of 14 m/s, and CAVI ≥9.059 corresponded to a baPWV cutoff of 18 m/s. The results of this ongoing prospective study are expected to confirm the association between the CAVI reference value and cardiovascular events.
| Mualliflar | Tomoyuki Kabutoya, Kazuomi Kario |
|---|---|
| Jurnal | PULSE |
| Nashr sanasi | 2018-01-01 |
| Jild | 6 |
| Son | 3-4 |
| Betlar | 131-136 |
| Til | en |
| DOI | 10.1159/000489604 |
DOI: 10.1159/000489604 · Maqolaning asl sahifasi
Alongside cancer, cardiovascular disease (CVD) exhibits the highest rates of morbidity and mortality globally, in western society as well as in Asian countries. Aging is a serious problem for the Asian population as…
Background: Gender-related differences in phenotypic expression and outcomes have been established in many cardiac conditions; however, the impact of gender in hypertrophic cardiomyopathy (HCM) remains unclear. We…
Sickle cell disease is an inherited hemoglobinopathy leading to the synthesis of hemoglobin S. Hemoglobin S results in the formation of abnormal sickle-shaped erythrocytes that lead to hematologic abnormalities such as…
Chronic obstructive pulmonary disease (COPD) patients are at a high risk of developing cardiovascular diseases. Airflow limitation is a predictor of future risks of hypertension and cardiovascular events. COPD is now…
Large artery stiffness (LAS) has proven to be an independent risk factor for cardiovascular disease and mortality. Nevertheless, the position of current hypertension guidelines regarding the usefulness of assessing LAS…
The Japanese Society of Hypertension (JSH) published the new JSH guidelines for the management of hypertension in 2014, which is the revision of the JSH guidelines of 2009. The primary objective of the guideline is to…
Background: Exercise training elicits indubitable positive adaptation in microcirculation in health and disease populations. An inclusive overview of the current knowledge regarding the effects of exercise on…
Stiffening of large arteries is a hallmark of vascular aging and one of the most important determinants of the age-related increase in blood pressure and cardiovascular disease events. Despite a substantial genetic…
Diabetes may induce multiple organ damage; therefore, early detection of individuals at high-risk of incident diabetes is important for timely risk assessment and intervention. Arterial stiffness (AS) occurs as a result…
There is a plausible physiological theory, supported by many observational studies, that vitamin D supplementation should be effective for improving cardiovascular end points, such as blood pressure (BP), large artery…