Vascular Aging and Cognitive Dysfunction: Silent Midlife Crisis in the Brain

Chen-Hua Lin, Hao‐Min Cheng, Shao‐Yuan Chuang, Chen‐Huan Chen

PULSE · 2017-yil

Annotatsiya

BACKGROUND: Vascular aging may cause cerebral microvascular damage and cognitive dysfunction. There is incremental evidence that consistently implicates arterial stiffness being involved in the manifestation of cognitive impairment in the elderly. However, few investigations have examined the relationship between arterial stiffness and cognitive impairment in midlife. SUMMARY: Past studies inconsistently showed improved cognitive outcomes after antihypertensive therapy in elderly populations. Nevertheless, recent findings revealed that blood-pressure-lowering treatment in young adults might eliminate or halt the progression of the detrimental effects related to arterial stiffness, indicating that younger adults may have more favorable outcomes in cognition than their older counterparts if early intervention is conducted at the subclinical stage. Stiffening of the aorta may lead to an excessive flow pulsatility in the brain that may cause microvascular structural brain damage and worse cognitive performance. Recent investigations have suggested that arterial stiffness is likely to trigger initial silent brain damage, possibly preceding midlife, while the manifestation of cognitive decline and deterioration can be foreseen in the subsequent life span. KEY MESSAGE: Despite the recent novel findings, definite conclusions on causality between vascular aging and cognitive dysfunction cannot be drawn at present. Further well-powered longitudinal studies with superior neuroimaging indicator, vascular mechanical biomarkers, and sensitive cognitive assessment tools that examine a broad range of age populations may help extend our understanding of the association between vascular aging and cognitive dysfunction throughout the life span.

Maqola ma’lumotlari
MualliflarChen-Hua Lin, Hao‐Min Cheng, Shao‐Yuan Chuang, Chen‐Huan Chen
JurnalPULSE
NashriyotPROFI университетининг
ISSN2074-1855, 2235-8668
Nashr sanasi2017-01-01
Jild5
Son1-4
Betlar127-132
TilIngliz
Ilmiy sohaPsixologiya
DOI10.1159/000481734
Indeksga qo‘shilgan2026-09-02

DOI: 10.1159/000481734 · Maqolaning asl sahifasi

Ilmiy soha

Psixologiya

Iqtibos keltirish

APAChen-Hua Lin, Hao‐Min Cheng, Shao‐Yuan Chuang, & Chen‐Huan Chen (2017). Vascular Aging and Cognitive Dysfunction: Silent Midlife Crisis in the Brain. PULSE, 5(1-4), 127-132. https://doi.org/10.1159/000481734
GOST (OAK)Chen-Hua Lin va b. Vascular Aging and Cognitive Dysfunction: Silent Midlife Crisis in the Brain // PULSE. – 2017. – T. 5, № 1-4. – P. 127-132. – DOI: 10.1159/000481734.
MLAChen-Hua Lin, Hao‐Min Cheng, Shao‐Yuan Chuang, and Chen‐Huan Chen. “Vascular Aging and Cognitive Dysfunction: Silent Midlife Crisis in the Brain.” PULSE, 5(1-4), 127-132, 2017. https://doi.org/10.1159/000481734
ChicagoChen-Hua Lin, Hao‐Min Cheng, Shao‐Yuan Chuang, and Chen‐Huan Chen. “Vascular Aging and Cognitive Dysfunction: Silent Midlife Crisis in the Brain.” PULSE, 5(1-4), 127-132 (2017). https://doi.org/10.1159/000481734
HarvardChen-Hua Lin, Hao‐Min Cheng, Shao‐Yuan Chuang, and Chen‐Huan Chen (2017) ‘Vascular Aging and Cognitive Dysfunction: Silent Midlife Crisis in the Brain’, PULSE, 5(1-4), 127-132. https://doi.org/10.1159/000481734
BibTeX
@article{chenhualin2017,
  title = {Vascular Aging and Cognitive Dysfunction: Silent Midlife Crisis in the Brain},
  author = {Chen-Hua Lin and Hao‐Min Cheng and Shao‐Yuan Chuang and Chen‐Huan Chen},
  journal = {PULSE},
  year = {2017},
  volume = {5},
  number = {1-4},
  pages = {127-132},
  doi = {10.1159/000481734},
  url = {https://doi.org/10.1159/000481734}
}

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