Arterial Stiffness Gradient

Catherine Fortier, Mohsen Agharazii

PULSE · 2015-yil

Annotatsiya

BACKGROUND: Aortic stiffness is a strong predictor of cardiovascular mortality in various clinical conditions. The aim of this review is to focus on the arterial stiffness gradient, to discuss the integrated role of medium-sized muscular conduit arteries in the regulation of pulsatile pressure and organ perfusion and to provide a rationale for integrating their mechanical properties into risk prediction. SUMMARY: The physiological arterial stiffness gradient results from a higher degree of vascular stiffness as the distance from the heart increases, creating multiple reflective sites and attenuating the pulsatile nature of the forward pressure wave along the arterial tree down to the microcirculation. The stiffness gradient hypothesis simultaneously explains its physiological beneficial effects from both cardiac and peripheral microcirculatory points of view. The loss or reversal of stiffness gradient leads to the transmission of a highly pulsatile pressure wave into the microcirculation. This suggests that a higher degree of stiffness of medium-sized conduit arteries may play a role in protecting the microcirculation from a highly pulsatile forward pressure wave. Using the ratio of carotid-femoral pulse wave velocity (PWV) to carotid-radial PWV, referred to as PWV ratio, a recent study in a dialysis cohort has shown that the PWV ratio is a better predictor of mortality than the classical carotid-femoral PWV. KEY MESSAGES: Theoretically, the use of the PWV ratio seems more logical for risk determination than aortic stiffness as it provides a better estimation of the loss of stiffness gradient, which is the unifying hypothesis that explains the impact of aortic stiffness both on the myocardium and on peripheral organs.

Maqola ma’lumotlari
MualliflarCatherine Fortier, Mohsen Agharazii
JurnalPULSE
NashriyotPROFI университетининг
ISSN2074-1855, 2235-8668
Nashr sanasi2015-01-01
Jild3
Son3-4
Betlar159-166
TilIngliz
Ilmiy sohaPsixologiya
DOI10.1159/000438852
Indeksga qo‘shilgan2026-09-02

DOI: 10.1159/000438852 · Maqolaning asl sahifasi

Ilmiy soha

Psixologiya

Iqtibos keltirish

APACatherine Fortier, & Mohsen Agharazii (2015). Arterial Stiffness Gradient. PULSE, 3(3-4), 159-166. https://doi.org/10.1159/000438852
GOST (OAK)Catherine Fortier, Mohsen Agharazii Arterial Stiffness Gradient // PULSE. – 2015. – T. 3, № 3-4. – P. 159-166. – DOI: 10.1159/000438852.
MLACatherine Fortier, and Mohsen Agharazii. “Arterial Stiffness Gradient.” PULSE, 3(3-4), 159-166, 2015. https://doi.org/10.1159/000438852
ChicagoCatherine Fortier, and Mohsen Agharazii. “Arterial Stiffness Gradient.” PULSE, 3(3-4), 159-166 (2015). https://doi.org/10.1159/000438852
HarvardCatherine Fortier, and Mohsen Agharazii (2015) ‘Arterial Stiffness Gradient’, PULSE, 3(3-4), 159-166. https://doi.org/10.1159/000438852
BibTeX
@article{catherinefortier2015,
  title = {Arterial Stiffness Gradient},
  author = {Catherine Fortier and Mohsen Agharazii},
  journal = {PULSE},
  year = {2015},
  volume = {3},
  number = {3-4},
  pages = {159-166},
  doi = {10.1159/000438852},
  url = {https://doi.org/10.1159/000438852}
}

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