The synthesis of novel thieno[3,2-d]pyrimidine derivatives commenced with 5-bromo-2-chlorobenzonitrile with ethyl-2-mercaptoacetate, which yielded the compound AT-2. The addition of piperidin-2-one to the formed AT-2 and subsequent cyclization yielded the compound AR-05. Subsequently, the Suzuki cross-coupling reaction was employed to facilitate the formation of a carbon-carbon bond. The intermediate AR-05 was formed in an alkaline medium in a toluene/water mixture in the presence of arylboronic acid and a palladium catalyst, forming a new C-C bond. AR-27 was synthesized as the final product. The structure of the new compounds was studied by analyzing the results obtained through the investigation of their physical and physicochemical properties.
| Mualliflar | Anvarjon Buronov, Azizbek Nasrullaev, Khurshed Bozorov, Nie Lifei, S. Kulmirzaeva, A. Ishankulov |
|---|---|
| Jurnal | Samarqand davlat universiteti ilmiy tadqiqotlar axborotnomasi |
| Nashr sanasi | 2025-03-29 |
| Jild | 1 |
| Son | 1 |
| Betlar | 5-11 |
| Til | en |
| DOI | 10.59251/2181-1296.2025.v1.149.2.3206 |
DOI: 10.59251/2181-1296.2025.v1.149.2.3206 · Maqolaning asl sahifasi
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