SYNTHESIS OF 6-SUBSTITUTED QUINAZOLINE-4-THIONES BY THE BUCHWALD HARTWIG METHOD

Davron Turgunov, Azizbek Nasrullaev, Khurshed Bozorov, N. Lifei, Haji Akber Aisa

Samarqand davlat universiteti ilmiy tadqiqotlar axborotnomasi · 2025-yil

Annotatsiya

To synthesize new derivatives of quinazolinones by the Buchwald-Hartwig method, 6-bromo-quinazolin-4-one derivatives were initially synthesized using cyclization methods and converted into 6-bromoquinazolin-4-thiones using Lawesson's reagent. These thione derivatives were reacted with aromatic amines in the presence of appropriate bases, palladium catalysts, and solvents, their chemical properties were studied and optimal conditions were selected. The structures of the resulting new compounds were studied based on 1H NMR, 13C NMR, MS, and MP analyses.

Maqola ma’lumotlari
MualliflarDavron Turgunov, Azizbek Nasrullaev, Khurshed Bozorov, N. Lifei, Haji Akber Aisa
JurnalSamarqand davlat universiteti ilmiy tadqiqotlar axborotnomasi
Nashr sanasi2025-03-29
Jild1
Son1
Betlar23-28
Tilen
DOI10.59251/2181-1296.2025.v1.149.2.3210

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