Synthesis of 3-SUBSTITUTED condensed pyrimidine derivatives via the sonogashira method

Zohidjon, Khushnazarov, Davron, Turgunov, Mirzokulov, Sunnatillo

Қўқон ДПИ. Илмий хабарлар · 2026-yil

Annotatsiya

This study investigates the Sonogashira cross-coupling reactions of 3- bromo-pyrido[2,3-d]pyrimidinone derivatives with terminal alkynes. The research was conducted in an inert atmosphere using a palladium catalyst and copper(I) iodide as a co- catalyst. The effects of various factors, including the catalyst system, base, solvent, and the structure of the alkynes, on the reaction efficiency were evaluated. The results demonstrate that the 3-bromo-pyrido[2,3-d]pyrimidinone scaffold exhibits sufficient reactivity in Sonogashira cross-coupling, yielding the corresponding ethynyl-substituted derivatives in moderate to high yields. The structures of the synthesized compounds were reliably confirmed by 1H and 13C NMR spectroscopy, mass spectral analysis, and melting point (MP) measurements.

Maqola ma’lumotlari
MualliflarZohidjon, Khushnazarov, Davron, Turgunov, Mirzokulov, Sunnatillo
JurnalҚўқон ДПИ. Илмий хабарлар
NashriyotҚўқон давлат педагогика институти
ISSN3030-3958
Nashr sanasi2026-10-10
Jild8
Son9
Betlar1320-1324
TilIngliz
DOI10.70728/a.series.tab.v08.i09.173
Indeksga qo‘shilgan2026-10-11

DOI: 10.70728/a.series.tab.v08.i09.173 · Maqolaning asl sahifasi

Kalit so‘zlar

3-bromo-pyrido[2, 3-d]pyrimidinones, ethynyl derivatives, palladium catalysts, copper(I) iodide, NMR spectroscopy, cesium carbonate, tetrahydrofuran.

Iqtibos keltirish

APAZohidjon, Khushnazarov, Davron, Turgunov, & Mirzokulov, Sunnatillo (2026). SYNTHESIS OF 3-SUBSTITUTED CONDENSED PYRIMIDINE DERIVATIVES VIA THE SONOGASHIRA METHOD. Қўқон ДПИ. Илмий хабарлар, 8(9), 1320-1324. https://doi.org/10.70728/a.series.tab.v08.i09.173
GOST (OAK)Zohidjon, Khushnazarov, Davron, Turgunov, Mirzokulov, Sunnatillo SYNTHESIS OF 3-SUBSTITUTED CONDENSED PYRIMIDINE DERIVATIVES VIA THE SONOGASHIRA METHOD // Қўқон ДПИ. Илмий хабарлар. – 2026. – T. 8, № 9. – P. 1320-1324. – DOI: 10.70728/a.series.tab.v08.i09.173.
MLAZohidjon, Khushnazarov, Davron, Turgunov, and Mirzokulov, Sunnatillo. “SYNTHESIS OF 3-SUBSTITUTED CONDENSED PYRIMIDINE DERIVATIVES VIA THE SONOGASHIRA METHOD.” Қўқон ДПИ. Илмий хабарлар, 8(9), 1320-1324, 2026. https://doi.org/10.70728/a.series.tab.v08.i09.173
ChicagoZohidjon, Khushnazarov, Davron, Turgunov, and Mirzokulov, Sunnatillo. “SYNTHESIS OF 3-SUBSTITUTED CONDENSED PYRIMIDINE DERIVATIVES VIA THE SONOGASHIRA METHOD.” Қўқон ДПИ. Илмий хабарлар, 8(9), 1320-1324 (2026). https://doi.org/10.70728/a.series.tab.v08.i09.173
HarvardZohidjon, Khushnazarov, Davron, Turgunov, and Mirzokulov, Sunnatillo (2026) ‘SYNTHESIS OF 3-SUBSTITUTED CONDENSED PYRIMIDINE DERIVATIVES VIA THE SONOGASHIRA METHOD’, Қўқон ДПИ. Илмий хабарлар, 8(9), 1320-1324. https://doi.org/10.70728/a.series.tab.v08.i09.173
BibTeX
@article{zohidjonkhushnazarov2026,
  title = {SYNTHESIS OF 3-SUBSTITUTED CONDENSED PYRIMIDINE DERIVATIVES VIA THE SONOGASHIRA METHOD},
  author = {Zohidjon, Khushnazarov and Davron, Turgunov and Mirzokulov, Sunnatillo},
  journal = {Қўқон ДПИ. Илмий хабарлар},
  year = {2026},
  volume = {8},
  number = {9},
  pages = {1320-1324},
  doi = {10.70728/a.series.tab.v08.i09.173},
  url = {https://doi.org/10.70728/a.series.tab.v08.i09.173}
}

Boshqa maqola uchun iqtibos tayyorlash

Қўқон ДПИ. Илмий хабарлар jurnalidan boshqa maqolalar

Қўқон ДПИ. Илмий хабарлар — barcha maqolalar · 2026-yil arxivi