Role of hyperhomocysteinemia in the pathogenesis and clinical course of chronic cerebral ischemia

Madjidova Y.N, Azimova N.M, Nizamhodjaeva S.B

Klinik fanlar yilnomasi · 2026-yil

Annotatsiya

Objective. To assess the relationship between plasma homocysteine levels and clinical-neurological, cognitive, neuroimaging, and hemodynamic parameters in patients with chronic cerebral ischemia (CCI). Materials and Methods. A prospective comparative study was conducted on 60 patients with CCI stages I–III. Cognitive status was evaluated using the MoCA and FAB scales. Brachiocephalic arteries were assessed by Doppler ultrasound, brain MRI was performed with Fazekas scale scoring, and plasma homocysteine levels were measured. Results. Homocysteine levels increased significantly with the severity of CCI (p<0.001). Elevated hyperhomocysteinemia was associated with decreased MoCA and FAB scores, thickening of the carotid artery intima–media complex, increased frequency of ≥50% stenosis, and a higher number of leukoaraiosis and lacunar infarcts on MRI (p<0.001). Homocysteine levels correlated negatively with MoCA scores (r=–0.52) and positively with Fazekas scale scores (r=+0.57). Conclusion. Hyperhomocysteinemia may serve as an independent biomarker of chronic cerebral ischemia progression and severity of cognitive impairment.

Maqola ma’lumotlari
MualliflarMadjidova Y.N, Azimova N.M, Nizamhodjaeva S.B
JurnalKlinik fanlar yilnomasi
NashriyotБухоро давлат тиббиёт институти
ISSN2025-2026, 0009-0006
Nashr sanasi2026-05-02
Jild3
Son1/2
TilIngliz
Ilmiy sohaTibbiyot
Indeksga qo‘shilgan2026-08-26

Maqolaning asl sahifasi

Kalit so‘zlar

chronic cerebral ischemia, hyperhomocysteinemia, cognitive impairment, leukoaraiosis, lacunar infarc, сурункали мия ишемияси, гипергомоцистеинемия, когнитив бузилиш, лейкоареоз, лакунар инфаркт, сурункали мия ишемияси, гипергомоцистеинемия, когнитив бузилиш, лейкоареоз, лакунар инфаркт

Ilmiy soha

Tibbiyot

Iqtibos keltirish

APAMadjidova Y.N, Azimova N.M, & Nizamhodjaeva S.B (2026). ROLE OF HYPERHOMOCYSTEINEMIA IN THE PATHOGENESIS AND CLINICAL COURSE OF CHRONIC CEREBRAL ISCHEMIA. Klinik fanlar yilnomasi, 3(1/2). https://tadqiqot.uz/index.php/spjacd/article/view/13653
GOST (OAK)Madjidova Y.N, Azimova N.M, Nizamhodjaeva S.B ROLE OF HYPERHOMOCYSTEINEMIA IN THE PATHOGENESIS AND CLINICAL COURSE OF CHRONIC CEREBRAL ISCHEMIA // Klinik fanlar yilnomasi. – 2026. – T. 3, № 1/2.
MLAMadjidova Y.N, Azimova N.M, and Nizamhodjaeva S.B. “ROLE OF HYPERHOMOCYSTEINEMIA IN THE PATHOGENESIS AND CLINICAL COURSE OF CHRONIC CEREBRAL ISCHEMIA.” Klinik fanlar yilnomasi, 3(1/2), 2026. https://tadqiqot.uz/index.php/spjacd/article/view/13653
ChicagoMadjidova Y.N, Azimova N.M, and Nizamhodjaeva S.B. “ROLE OF HYPERHOMOCYSTEINEMIA IN THE PATHOGENESIS AND CLINICAL COURSE OF CHRONIC CEREBRAL ISCHEMIA.” Klinik fanlar yilnomasi, 3(1/2) (2026). https://tadqiqot.uz/index.php/spjacd/article/view/13653
HarvardMadjidova Y.N, Azimova N.M, and Nizamhodjaeva S.B (2026) ‘ROLE OF HYPERHOMOCYSTEINEMIA IN THE PATHOGENESIS AND CLINICAL COURSE OF CHRONIC CEREBRAL ISCHEMIA’, Klinik fanlar yilnomasi, 3(1/2). https://tadqiqot.uz/index.php/spjacd/article/view/13653
BibTeX
@article{madjidovayn2026,
  title = {ROLE OF HYPERHOMOCYSTEINEMIA IN THE PATHOGENESIS AND CLINICAL COURSE OF CHRONIC CEREBRAL ISCHEMIA},
  author = {Madjidova Y.N and Azimova N.M and Nizamhodjaeva S.B},
  journal = {Klinik fanlar yilnomasi},
  year = {2026},
  volume = {3},
  number = {1/2},
  url = {https://tadqiqot.uz/index.php/spjacd/article/view/13653}
}

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