Drug-induced parkinsonism: clinical predictors, differential diagnosis, therapeutic algorithms

Li M.S, Alikulova X.I, Azimova K.I

Klinik fanlar yilnomasi · 2026-yil

Annotatsiya

Objective. Systematization of data on drug-induced parkinsonism (DIP) to optimize diagnostic and treatment algorithms in neurological and psychiatric practice. Methods. An analytical review of modern clinical studies and guidelines for 2020–2025 regarding the epidemiology, pathogenesis, and therapy of DIP was conducted. Results. DIP ranks second among the causes of parkinsonism in the elderly. The main inducers are typical antipsychotics and calcium channel blockers (cinnarizine, flunarizine). Key criteria for differentiating DIP from Parkinson's disease (PD) were identified: symmetry of symptoms, subacute course, and lack of progression after drug withdrawal. The efficacy of amantadine as a first-line drug for DIP correction in elderly patients was confirmed due to a safety profile superior to anticholinergics. Conclusion. Timely identification of DIP and modification of pharmacotherapy (dose de-escalation, rotation of antipsychotics) allow for complete regression of symptoms in 75–85% of cases.

Maqola ma’lumotlari
MualliflarLi M.S, Alikulova X.I, Azimova K.I
JurnalKlinik fanlar yilnomasi
NashriyotБухоро давлат тиббиёт институти
ISSN2025-2026, 0009-0006
Nashr sanasi2026-05-02
Jild3
Son1/2
TilIngliz
Ilmiy sohaTibbiyot
Indeksga qo‘shilgan2026-08-26

Maqolaning asl sahifasi

Kalit so‘zlar

drug-induced parkinsonism, antipsychotics, extrapyramidal disorders, amantadine, differential diagnosis, лекарственный паркинсонизм, антипсихотики, экстрапирамидные расстройства, амантадин, дифференциальная диагностика, dori vositalari keltirib chiqaradigan parkinsonizm, antipsixotiklar, ekstrapiramidal buzilishlar, amantadin, qiyosiy tashxis

Ilmiy soha

Tibbiyot

Iqtibos keltirish

APALi M.S, Alikulova X.I, & Azimova K.I (2026). DRUG-INDUCED PARKINSONISM: CLINICAL PREDICTORS, DIFFERENTIAL DIAGNOSIS, THERAPEUTIC ALGORITHMS. Klinik fanlar yilnomasi, 3(1/2). https://tadqiqot.uz/index.php/spjacd/article/view/13652
GOST (OAK)Li M.S, Alikulova X.I, Azimova K.I DRUG-INDUCED PARKINSONISM: CLINICAL PREDICTORS, DIFFERENTIAL DIAGNOSIS, THERAPEUTIC ALGORITHMS // Klinik fanlar yilnomasi. – 2026. – T. 3, № 1/2.
MLALi M.S, Alikulova X.I, and Azimova K.I. “DRUG-INDUCED PARKINSONISM: CLINICAL PREDICTORS, DIFFERENTIAL DIAGNOSIS, THERAPEUTIC ALGORITHMS.” Klinik fanlar yilnomasi, 3(1/2), 2026. https://tadqiqot.uz/index.php/spjacd/article/view/13652
ChicagoLi M.S, Alikulova X.I, and Azimova K.I. “DRUG-INDUCED PARKINSONISM: CLINICAL PREDICTORS, DIFFERENTIAL DIAGNOSIS, THERAPEUTIC ALGORITHMS.” Klinik fanlar yilnomasi, 3(1/2) (2026). https://tadqiqot.uz/index.php/spjacd/article/view/13652
HarvardLi M.S, Alikulova X.I, and Azimova K.I (2026) ‘DRUG-INDUCED PARKINSONISM: CLINICAL PREDICTORS, DIFFERENTIAL DIAGNOSIS, THERAPEUTIC ALGORITHMS’, Klinik fanlar yilnomasi, 3(1/2). https://tadqiqot.uz/index.php/spjacd/article/view/13652
BibTeX
@article{lims2026,
  title = {DRUG-INDUCED PARKINSONISM: CLINICAL PREDICTORS, DIFFERENTIAL DIAGNOSIS, THERAPEUTIC ALGORITHMS},
  author = {Li M.S and Alikulova X.I and Azimova K.I},
  journal = {Klinik fanlar yilnomasi},
  year = {2026},
  volume = {3},
  number = {1/2},
  url = {https://tadqiqot.uz/index.php/spjacd/article/view/13652}
}

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