Objective. Systematization of data on drug-induced parkinsonism (DIP) to optimize diagnostic and treatment algorithms in neurological and psychiatric practice. Methods. An analytical review of modern clinical studies and guidelines for 2020–2025 regarding the epidemiology, pathogenesis, and therapy of DIP was conducted. Results. DIP ranks second among the causes of parkinsonism in the elderly. The main inducers are typical antipsychotics and calcium channel blockers (cinnarizine, flunarizine). Key criteria for differentiating DIP from Parkinson's disease (PD) were identified: symmetry of symptoms, subacute course, and lack of progression after drug withdrawal. The efficacy of amantadine as a first-line drug for DIP correction in elderly patients was confirmed due to a safety profile superior to anticholinergics. Conclusion. Timely identification of DIP and modification of pharmacotherapy (dose de-escalation, rotation of antipsychotics) allow for complete regression of symptoms in 75–85% of cases.
| Mualliflar | Li M.S, Alikulova X.I, Azimova K.I |
|---|---|
| Jurnal | Klinik fanlar yilnomasi |
| Nashr sanasi | 2026-05-02 |
| Jild | 3 |
| Son | 1/2 |
| Til | Rus |
drug-induced parkinsonism, antipsychotics, extrapyramidal disorders, amantadine, differential diagnosis, лекарственный паркинсонизм, антипсихотики, экстрапирамидные расстройства, амантадин, дифференциальная диагностика, dori vositalari keltirib chiqaradigan parkinsonizm, antipsixotiklar, ekstrapiramidal buzilishlar, amantadin, qiyosiy tashxis
Objective. To assess the relationship between plasma homocysteine levels and clinical-neurological, cognitive, neuroimaging, and hemodynamic parameters in patients with chronic cerebral ischemia (CCI). Materials and…
The article presents data on the prevalence of Helicobacter pylori infection in the cities of Tashkent and Nukus in 2025. The study was conducted at the outpatient clinics of the Republican Specialized Scientific and…
In patients with locally and locally advanced gastric tumors, functional disorders and an excess of nutritional deficiencies led to the development of "rehabilitation" concept. Multimodal rehabilitation involves a…
Perinatal lesions of the central nervous system occupy a leading position in the structure of pediatric neurological disorders. The high prevalence of this condition, together with the risk of persistent functional…
In acute diarrhea cases among HIV-infected children, a high proportion of mixed infections was observed; bacterial-bacterial (47.5%) and bacterial-viral (27.2%), while mixed viral-viral infections were detected 1.8…
APS (antiphospholipid syndrome) is a disruption of the body's autoimmune response, manifesting as miscarriages and thromboembolic complications during pregnancy. It is associated with a high risk of obstetric and…
Forty-five patients under 65 years of age with chronic suppurative otitis media were observed. Men constituted 56.6%, women 43.3%. In addition to signs of inflammation, general anxiety, poor sleep, and food refusal were…
This article assesses oral health-related quality of life in elderly patients requiring orthopedic rehabilitation using the validated OHIP-14 questionnaire. The survey was administered before prosthetic treatment and on…
The article contains information on assessing the quality of life of patients diagnosed with “bilateral anterior dislocation of the TMJ articular disc”, carried out before, during and after completion of the proposed…
Orphan diseases represent a heterogeneous group of disorders characterized by low individual prevalence; however, their cumulative frequency constitutes a substantial global burden on healthcare systems. According to…