This article presents the results of a study examining the role of nerve growth factor (NGF) as a biochemical marker of neurogenic bladder dysfunction in women with urgency urinary incontinence (UUI) due to diabetes mellitus (DM). Eighty-six women aged 45– 65 years with UUI due to type 1 and type 2 diabetes complicated by diabetic autonomic neuropathy and 55 healthy women in the control group were examined. Urinary NGF levels were determined by enzyme-linked immunosorbent assay (ELISA) with normalization for creatinine concentration. A correlation analysis of NGF with urgency frequency, urinary incontinence episodes, total urination frequency, and the results of the validated ICIQ-SF and OAB-q questionnaires was performed. The results showed that in patients with UUI and diabetes, the level of NGF/Cr was significantly higher than in healthy women (42.8 ± 11.6 pg/mg versus 18.9 ± 6.4 pg/mg, p < 0.001), while in women with type 2 diabetes, NGF/Cr exceeded the levels in type 1 diabetes (45.1 ± 11.9 versus 37.6 ± 9.8 pg/mg, p < 0.05). Correlation analysis revealed a significant positive relationship between NGF levels and the frequency of urinary urgency (r = 0.52), episodes of UUI (r = 0.49), total urination frequency (r = 0.45), ICIQ-SF total score (r = 0.47), and OAB-q symptom scale (r = 0.54, all p < 0.05–0.01). The obtained data confirm the pathogenetic role of NGF as a marker of sensory overactivity of the bladder in women with diabetes mellitus and neurogenic bladder dysfunction.
| Mualliflar | Махматкулов Содикжон Машраф угли, Мавлянова Зилола Фархадовна, Ашуров Рустамжон Фуркатович |
|---|---|
| Jurnal | Журнал неврологии и нейрохирургических исследований / Journal of Neurology and Neurosurgical Research |
| Nashr sanasi | 2026-04-01 |
| Jild | 7 |
| Son | 1 |
| Til | Rus |
ургентное недержание мочи, сахарный диабет, диабетическая автономная нейропатия, фактор роста нервов (NGF), нейрогенная дисфункция мочевого пузыря, ELISA, ICIQ-SF, OAB-q, urge urinary incontinence, diabetes mellitus, diabetic autonomic neuropathy, nerve growth factor (NGF), neurogenic bladder dysfunction, ELISA, ICIQ-SF, OAB-q, ургент сийдик тутолмаслик, қандли диабет, диабетик автоном нейропатия, нерв ўсиш омили (NGF), сийдик пуфагининг нейроген дисфункцияси, ELISA, ICIQ-SF, OAB-q
Functional gastrointestinal disorders (FGIDs) in infants during the first year of life are among the most common problems in pediatric practice. The aim of the study was to assess the role of laboratory and instrumental…
This article presents the results of a study of myofascial pain syndrome (MFPS) of the neck and shoulder girdle in working-age individuals with occupational risk. The clinical and functional characteristics of the…
Traumatic leptomeningeal cyst or growing skull fracture is a rare disease that occurs primarily in childhood. The manifestations of leptomeningeal cysts in adults are often associated with injuries sustained in…
Parkinson's disease (PD) is one of the most common neurodegenerative diseases characterized by progressive damage to dopaminergic neurons of the black substance and the development of a characteristic symptom complex of…
Relevance. Pathology of the spine and spinal cord is a pressing medico-social problem in Uzbekistan. Managing combined pathology (stenosis, metal constructs, degenerative changes) forming a "post-traumatic cascade"…
The article presents results of a comparative cohort study of 379 patients in the early recovery period after ischemic stroke. Speech and cognitive function characteristics were examined using standardized scales (MoCA…
Intellectual disability is one of the urgent medical and social problems of modern society, having a significant impact on the quality of life of patients and their families. Genetic factors, including related…
ABSTRACT Background. Chronic migraine is a highly disabling condition with a significant proportion of patients refractory to conservative treatment. The absence of a standardized approach to differential diagnosis of…
Facial nerve neuropathy remains one of the most pressing problems in neurology and otolaryngology, despite significant achievements in the development of diagnostic and treatment methods. According to WHO data, the…
Background. Facial pain is a clinically heterogeneous syndrome in outpatient neurology. Trigeminal neuralgia is traditionally regarded as a clearly defined nosological entity; however, pain syndromes associated with…