Nerve growth factor (ngf) as a biochemical marker of neurogenic bladder dysfunction in women with urgent urinary incontinence associated with diabetes mellitus

Махматкулов Содикжон Машраф угли, Мавлянова Зилола Фархадовна, Ашуров Рустамжон Фуркатович

Журнал неврологии и нейрохирургических исследований / Journal of Neurology and Neurosurgical Research · 2026-yil

Annotatsiya

This article presents the results of a study examining the role of nerve growth factor (NGF) as a biochemical marker of neurogenic bladder dysfunction in women with urgency urinary incontinence (UUI) due to diabetes mellitus (DM). Eighty-six women aged 45– 65 years with UUI due to type 1 and type 2 diabetes complicated by diabetic autonomic neuropathy and 55 healthy women in the control group were examined. Urinary NGF levels were determined by enzyme-linked immunosorbent assay (ELISA) with normalization for creatinine concentration. A correlation analysis of NGF with urgency frequency, urinary incontinence episodes, total urination frequency, and the results of the validated ICIQ-SF and OAB-q questionnaires was performed. The results showed that in patients with UUI and diabetes, the level of NGF/Cr was significantly higher than in healthy women (42.8 ± 11.6 pg/mg versus 18.9 ± 6.4 pg/mg, p < 0.001), while in women with type 2 diabetes, NGF/Cr exceeded the levels in type 1 diabetes (45.1 ± 11.9 versus 37.6 ± 9.8 pg/mg, p < 0.05). Correlation analysis revealed a significant positive relationship between NGF levels and the frequency of urinary urgency (r = 0.52), episodes of UUI (r = 0.49), total urination frequency (r = 0.45), ICIQ-SF total score (r = 0.47), and OAB-q symptom scale (r = 0.54, all p < 0.05–0.01). The obtained data confirm the pathogenetic role of NGF as a marker of sensory overactivity of the bladder in women with diabetes mellitus and neurogenic bladder dysfunction.

Maqola ma’lumotlari
MualliflarМахматкулов Содикжон Машраф угли, Мавлянова Зилола Фархадовна, Ашуров Рустамжон Фуркатович
JurnalЖурнал неврологии и нейрохирургических исследований / Journal of Neurology and Neurosurgical Research
NashriyotБухоро давлат тиббиёт институти
Nashr sanasi2026-04-01
Jild7
Son1
TilIngliz
Ilmiy sohaTibbiyot
Indeksga qo‘shilgan2026-08-26

Maqolaning asl sahifasi

Kalit so‘zlar

ургентное недержание мочи, сахарный диабет, диабетическая автономная нейропатия, фактор роста нервов (NGF), нейрогенная дисфункция мочевого пузыря, ELISA, ICIQ-SF, OAB-q, urge urinary incontinence, diabetes mellitus, diabetic autonomic neuropathy, nerve growth factor (NGF), neurogenic bladder dysfunction, ELISA, ICIQ-SF, OAB-q, ургент сийдик тутолмаслик, қандли диабет, диабетик автоном нейропатия, нерв ўсиш омили (NGF), сийдик пуфагининг нейроген дисфункцияси, ELISA, ICIQ-SF, OAB-q

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Iqtibos keltirish

APAМахматкулов Содикжон Машраф угли, Мавлянова Зилола Фархадовна, & Ашуров Рустамжон Фуркатович (2026). NERVE GROWTH FACTOR (NGF) AS A BIOCHEMICAL MARKER OF NEUROGENIC BLADDER DYSFUNCTION IN WOMEN WITH URGENT URINARY INCONTINENCE ASSOCIATED WITH DIABETES MELLITUS. Журнал неврологии и нейрохирургических исследований / Journal of Neurology and Neurosurgical Research, 7(1). https://tadqiqot.uz/index.php/neurology/article/view/13372
GOST (OAK)Махматкулов Содикжон Машраф угли, Мавлянова Зилола Фархадовна, Ашуров Рустамжон Фуркатович NERVE GROWTH FACTOR (NGF) AS A BIOCHEMICAL MARKER OF NEUROGENIC BLADDER DYSFUNCTION IN WOMEN WITH URGENT URINARY INCONTINENCE ASSOCIATED WITH DIABETES MELLITUS // Журнал неврологии и нейрохирургических исследований / Journal of Neurology and Neurosurgical Research. – 2026. – T. 7, № 1.
MLAМахматкулов Содикжон Машраф угли, Мавлянова Зилола Фархадовна, and Ашуров Рустамжон Фуркатович. “NERVE GROWTH FACTOR (NGF) AS A BIOCHEMICAL MARKER OF NEUROGENIC BLADDER DYSFUNCTION IN WOMEN WITH URGENT URINARY INCONTINENCE ASSOCIATED WITH DIABETES MELLITUS.” Журнал неврологии и нейрохирургических исследований / Journal of Neurology and Neurosurgical Research, 7(1), 2026. https://tadqiqot.uz/index.php/neurology/article/view/13372
ChicagoМахматкулов Содикжон Машраф угли, Мавлянова Зилола Фархадовна, and Ашуров Рустамжон Фуркатович. “NERVE GROWTH FACTOR (NGF) AS A BIOCHEMICAL MARKER OF NEUROGENIC BLADDER DYSFUNCTION IN WOMEN WITH URGENT URINARY INCONTINENCE ASSOCIATED WITH DIABETES MELLITUS.” Журнал неврологии и нейрохирургических исследований / Journal of Neurology and Neurosurgical Research, 7(1) (2026). https://tadqiqot.uz/index.php/neurology/article/view/13372
HarvardМахматкулов Содикжон Машраф угли, Мавлянова Зилола Фархадовна, and Ашуров Рустамжон Фуркатович (2026) ‘NERVE GROWTH FACTOR (NGF) AS A BIOCHEMICAL MARKER OF NEUROGENIC BLADDER DYSFUNCTION IN WOMEN WITH URGENT URINARY INCONTINENCE ASSOCIATED WITH DIABETES MELLITUS’, Журнал неврологии и нейрохирургических исследований / Journal of Neurology and Neurosurgical Research, 7(1). https://tadqiqot.uz/index.php/neurology/article/view/13372
BibTeX
@article{article2026,
  title = {NERVE GROWTH FACTOR (NGF) AS A BIOCHEMICAL MARKER OF NEUROGENIC BLADDER DYSFUNCTION IN WOMEN WITH URGENT URINARY INCONTINENCE ASSOCIATED WITH DIABETES MELLITUS},
  author = {Махматкулов Содикжон Машраф угли and Мавлянова Зилола Фархадовна and Ашуров Рустамжон Фуркатович},
  journal = {Журнал неврологии и нейрохирургических исследований / Journal of Neurology and Neurosurgical Research},
  year = {2026},
  volume = {7},
  number = {1},
  url = {https://tadqiqot.uz/index.php/neurology/article/view/13372}
}

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