Neurophysiological and biochemical criteria in the diagnosis of progressive muscular dystrophies

Маджидова Якутхон Набиевна, Назарова Гулнора Таджидиновна

Журнал неврологии и нейрохирургических исследований / Journal of Neurology and Neurosurgical Research · 2026-yil

Annotatsiya

A comprehensive clinical examination, electroneuromyography (ENMG), electromyography (EMG), biochemical tests (creatine kinase, lactate dehydrogenase, aminotransferases, troponin I), and inflammatory markers (interleukins, TNF-α) were performed in 25 patients with progressive muscular dystrophy. Creatine kinase levels were elevated in all patients, averaging 2840±1650 U/L. The highest values (4250±1980 U/L) were observed in patients with Duchenne muscular dystrophy. Electromyographic studies revealed myopathic changes in all patients: PDE amplitude was 485±180 μV, duration was 7.2±2.1 ms, and polyphasicity was 28.4±8.6%. Elevated troponin I levels were detected in 8 patients (32%). Most patients had elevated inflammatory markers (IL-1β, IL-6, TNF-α). Comprehensive diagnostics are highly effective in detecting progressive muscular dystrophy, increasing diagnostic accuracy to 92% and improving differential diagnosis of various forms of the disease.

Maqola ma’lumotlari
MualliflarМаджидова Якутхон Набиевна, Назарова Гулнора Таджидиновна
JurnalЖурнал неврологии и нейрохирургических исследований / Journal of Neurology and Neurosurgical Research
NashriyotБухоро давлат тиббиёт институти
Nashr sanasi2026-03-24
Jild7
Son2
TilIngliz
Ilmiy sohaTibbiyot
Indeksga qo‘shilgan2026-08-26

Maqolaning asl sahifasi

Kalit so‘zlar

jadallashuvchi mushak distrofiyasi, elektromiografiya, kreatinkinaza, biokimyoviy markerlar, kompleks diagnostika, neyrofiziologiya, progressive muscular dystrophy, electromyography, creatine kinase, biochemical markers, comprehensive diagnostics, neurophysiology, jadallashuvchi mushak distrofiyasi, elektromiografiya, kreatinkinaza, biokimyoviy markerlar, kompleks diagnostika, neyrofiziologiya

Ilmiy soha

Tibbiyot

Iqtibos keltirish

APAМаджидова Якутхон Набиевна, & Назарова Гулнора Таджидиновна (2026). NEUROPHYSIOLOGICAL AND BIOCHEMICAL CRITERIA IN THE DIAGNOSIS OF PROGRESSIVE MUSCULAR DYSTROPHIES. Журнал неврологии и нейрохирургических исследований / Journal of Neurology and Neurosurgical Research, 7(2). https://tadqiqot.uz/index.php/neurology/article/view/13294
GOST (OAK)Маджидова Якутхон Набиевна, Назарова Гулнора Таджидиновна NEUROPHYSIOLOGICAL AND BIOCHEMICAL CRITERIA IN THE DIAGNOSIS OF PROGRESSIVE MUSCULAR DYSTROPHIES // Журнал неврологии и нейрохирургических исследований / Journal of Neurology and Neurosurgical Research. – 2026. – T. 7, № 2.
MLAМаджидова Якутхон Набиевна, and Назарова Гулнора Таджидиновна. “NEUROPHYSIOLOGICAL AND BIOCHEMICAL CRITERIA IN THE DIAGNOSIS OF PROGRESSIVE MUSCULAR DYSTROPHIES.” Журнал неврологии и нейрохирургических исследований / Journal of Neurology and Neurosurgical Research, 7(2), 2026. https://tadqiqot.uz/index.php/neurology/article/view/13294
ChicagoМаджидова Якутхон Набиевна, and Назарова Гулнора Таджидиновна. “NEUROPHYSIOLOGICAL AND BIOCHEMICAL CRITERIA IN THE DIAGNOSIS OF PROGRESSIVE MUSCULAR DYSTROPHIES.” Журнал неврологии и нейрохирургических исследований / Journal of Neurology and Neurosurgical Research, 7(2) (2026). https://tadqiqot.uz/index.php/neurology/article/view/13294
HarvardМаджидова Якутхон Набиевна, and Назарова Гулнора Таджидиновна (2026) ‘NEUROPHYSIOLOGICAL AND BIOCHEMICAL CRITERIA IN THE DIAGNOSIS OF PROGRESSIVE MUSCULAR DYSTROPHIES’, Журнал неврологии и нейрохирургических исследований / Journal of Neurology and Neurosurgical Research, 7(2). https://tadqiqot.uz/index.php/neurology/article/view/13294
BibTeX
@article{article2026,
  title = {NEUROPHYSIOLOGICAL AND BIOCHEMICAL CRITERIA IN THE DIAGNOSIS OF PROGRESSIVE MUSCULAR DYSTROPHIES},
  author = {Маджидова Якутхон Набиевна and Назарова Гулнора Таджидиновна},
  journal = {Журнал неврологии и нейрохирургических исследований / Journal of Neurology and Neurosurgical Research},
  year = {2026},
  volume = {7},
  number = {2},
  url = {https://tadqiqot.uz/index.php/neurology/article/view/13294}
}

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