Ushbu tadqiqotda GRK4 (G protein-coupled receptor kinase 4) darajasining ko‘krak bezi saratoni (KBS) bosqichlari bilan bog‘liqligi va uning endotelial disfunksiya bilan aloqasi o‘rganildi. Jami 52 nafar ayol bemor (31–74 yosh) tahlilga kiritildi. Zardobdagi GRK4 darajasi sandwich-ELISA usuli yordamida aniqlanib, erta bosqichda yuqoriroq (74,6 ± 18,2 ul), metastatik bosqichda esa pastroq (54,7 ± 31,4 ul) ko‘rsatkichlar qayd etildi (p = 0,047). ROC tahlilida GRK4 < 60 ul kesish nuqtasi metastatik shaklni 75 % sezuvchanlik va 83 % o‘ziga xoslik bilan farqlandi (AUC = 0,81). Gipertenziya, semizlik va qandli diabet bilan kechuvchi bemorlarda GRK4 darajasining pasaygani endotelial disfunksiya va saraton progressiyasi o‘rtasidagi bog‘liqlikni ko‘rsatadi. GRK4 ko‘krak bezi saratoni uchun istiqbolli diagnostik va prognostik biomarker sifatida baholanishi mumkin.
| Mualliflar | Mirzayeva M.A., Iriskulov B.U. |
|---|---|
| Jurnal | Ёш олимлар тиббиёт журнали |
| Nashr sanasi | 2025-12-13 |
| Son | 16 |
| Betlar | 9-12 |
| Til | Rus |
ko‘krak bezi saratoni, GRK4, endotelial disfunksiya, gipertenziya, semizlik, biomarker, ELISA
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