CONCOMITANT DYNAMICS OF OXIDATIVE STATUS AND MOTOR COORDINATION IN EXPERIMENTAL SPINAL TRAUMA

Khikmatullaev , Rukhulla Zabikhullaevich

Гуманитар ва табиий фанлар журнали · 2026-yil

Annotatsiya

To assess the concomitant dynamics of free-radical oxidation, total antioxidant status, and motor coordination following a standardized blunt injury to the lumbar spine in rats, with and without direct involvement of the spinal cord. In the biochemical and functional experimental series, intact animals and two experimental groups were studied. Spinal trauma was induced by the free fall of a 250-g weight from a height of either 20 or 40 cm onto a standardized region corresponding to LII–LIV. On days 3, 7, and 14 after injury, plasma concentrations of thiobarbituric acid-reactive substances (TBARS), total antioxidant status, and the duration of retention on a rotating rod using the Rota-Rod NG apparatus were assessed. In animals without spinal cord injury, the concentration of TBARS increased to 6.01 ± 0.43 μmol/L on day 3 and subsequently decreased to 3.72 ± 0.44 μmol/L by day 14, approaching the intact level of 3.48 ± 0.29 μmol/L. In animals with spinal cord injury, hyperlipoperoxidation was more pronounced and persisted throughout the observation period, with TBARS concentrations of 8.48 ± 0.64, 6.76 ± 0.57, and 6.43 ± 0.67 μmol/L on days 3, 7, and 14, respectively. Total antioxidant status increased as a compensatory response; however, in animals with spinal cord injury, it remained markedly elevated even on day 14, reaching 6.98 ± 0.71 mmol/L, compared with 2.44 ± 0.17 mmol/L in the control group. Functionally, these biochemical alterations were accompanied by incomplete recovery of motor performance, as reflected by the duration of retention on the Rota-Rod: 69.8 ± 6.7 s versus 103.8 ± 7.6 s in intact animals. The findings demonstrate that the prolonged simultaneous persistence of hyperlipoperoxidation and increased antioxidant-system activity is associated with sustained motor impairment and may be regarded as a pathogenetic criterion of the severity of spinal trauma with or without spinal cord involvement. 

Maqola ma’lumotlari
MualliflarKhikmatullaev , Rukhulla Zabikhullaevich
JurnalГуманитар ва табиий фанлар журнали
Nashr sanasi2026-06-12
Son34
Betlar295-305
TilRus

Maqolaning asl sahifasi

Kalit so‘zlar

spinal trauma, spinal cord injury, oxidative stress, thiobarbituric acid-reactive substances, total antioxidant status, motor coordination, Rota-Rod.

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