Comprehensive in silico evaluation of the physicochemical properties, pharmacokinetic profile, and drug-likeness of a newly synthesized DICHLOROBIS(6-METHOXY-1,3-BENZOTHIAZOL-2- amine)cobalt(ii) complex

Khushbokov, Abduvali Bakhodir Ugli, Turayev, Khayit Khudoynazarovich, Umbarov, Ibragim Amonovich, Choriyev, Odil Irgashevich, Ashurov, Jamshid Mengnorovich

Қўқон ДПИ. Илмий хабарлар · 2026-yil

Annotatsiya

Mazkur tadqiqotda yangi sintez qilingan dichlorobis(6-methoxy-1,3- benzothiazol-2-amine)cobalt(II) kompleksining fizik-kimyoviy xossalari, farmakokinetik profili, dori vositasiga o'xshashlik (drug-likeness) hamda medicinal chemistry ko'rsatkichlari SwissADME onlayn platformasi yordamida in silico usulda kompleks baholandi. Molekulyar tavsiflar, lipofillik, suvda eruvchanlik, ADME parametrlari, farmakokinetik xususiyatlar va dori vositasiga o'xshashlik mezonlariga muvofiqligi tizimli ravishda tahlil qilindi. Tadqiq etilgan kompleks o'rtacha lipofillik, qulay strukturaviy xususiyatlar hamda PAINS va Brenk ogohlantirishlarining mavjud emasligi bilan tavsiflandi. Suvda eruvchanlikning pastligi, oshqozon-ichak traktida so'rilishning cheklanganligi va ayrim empirik drug-likeness mezonlari bo'yicha kichik chetlanishlar aniqlangan bo'lsa-da, ushbu natijalar o'tish metallari koordinatsion birikmalarining o'ziga xos fizik-kimyoviy xususiyatlari bilan izohlanadi. Olingan natijalar tadqiq etilgan kobalt(II) kompleksining farmatsevtik istiqbolini nazariy jihatdan baholash hamda keyingi in vitro, in vivo va molekulyar docking tadqiqotlari uchun ilmiy asos yaratadi.

Maqola ma’lumotlari
MualliflarKhushbokov, Abduvali Bakhodir Ugli, Turayev, Khayit Khudoynazarovich, Umbarov, Ibragim Amonovich, Choriyev, Odil Irgashevich, Ashurov, Jamshid Mengnorovich
JurnalҚўқон ДПИ. Илмий хабарлар
NashriyotҚўқон давлат педагогика институти
ISSN3030-3958
Nashr sanasi2026-09-05
Jild8
Son6
Betlar801-815
TilIngliz
DOI10.70728/a.series.tab.v08.i06.109
Indeksga qo‘shilgan2026-09-06

DOI: 10.70728/a.series.tab.v08.i06.109 · Maqolaning asl sahifasi

Kalit so‘zlar

benzotiazol hosilalari, kobalt(II) kompleksi, SwissADME, in silico tahlil, fizik-kimyoviy xossalar, farmakokinetik profil, drug-likeness, medicinal chemistry, ADME, biofoydalanuvchanlik.

Iqtibos keltirish

APAKhushbokov, Abduvali Bakhodir Ugli, Turayev, Khayit Khudoynazarovich, Umbarov, Ibragim Amonovich, Choriyev, Odil Irgashevich, & Ashurov, Jamshid Mengnorovich (2026). COMPREHENSIVE IN SILICO EVALUATION OF THE PHYSICOCHEMICAL PROPERTIES, PHARMACOKINETIC PROFILE, AND DRUG-LIKENESS OF A NEWLY SYNTHESIZED DICHLOROBIS(6-METHOXY-1,3-BENZOTHIAZOL-2- AMINE)COBALT(II) COMPLEX. Қўқон ДПИ. Илмий хабарлар, 8(6), 801-815. https://doi.org/10.70728/a.series.tab.v08.i06.109
GOST (OAK)Khushbokov, Abduvali Bakhodir Ugli va b. COMPREHENSIVE IN SILICO EVALUATION OF THE PHYSICOCHEMICAL PROPERTIES, PHARMACOKINETIC PROFILE, AND DRUG-LIKENESS OF A NEWLY SYNTHESIZED DICHLOROBIS(6-METHOXY-1,3-BENZOTHIAZOL-2- AMINE)COBALT(II) COMPLEX // Қўқон ДПИ. Илмий хабарлар. – 2026. – T. 8, № 6. – P. 801-815. – DOI: 10.70728/a.series.tab.v08.i06.109.
MLAKhushbokov, Abduvali Bakhodir Ugli, Turayev, Khayit Khudoynazarovich, Umbarov, Ibragim Amonovich, Choriyev, Odil Irgashevich, and Ashurov, Jamshid Mengnorovich. “COMPREHENSIVE IN SILICO EVALUATION OF THE PHYSICOCHEMICAL PROPERTIES, PHARMACOKINETIC PROFILE, AND DRUG-LIKENESS OF A NEWLY SYNTHESIZED DICHLOROBIS(6-METHOXY-1,3-BENZOTHIAZOL-2- AMINE)COBALT(II) COMPLEX.” Қўқон ДПИ. Илмий хабарлар, 8(6), 801-815, 2026. https://doi.org/10.70728/a.series.tab.v08.i06.109
ChicagoKhushbokov, Abduvali Bakhodir Ugli, Turayev, Khayit Khudoynazarovich, Umbarov, Ibragim Amonovich, Choriyev, Odil Irgashevich, and Ashurov, Jamshid Mengnorovich. “COMPREHENSIVE IN SILICO EVALUATION OF THE PHYSICOCHEMICAL PROPERTIES, PHARMACOKINETIC PROFILE, AND DRUG-LIKENESS OF A NEWLY SYNTHESIZED DICHLOROBIS(6-METHOXY-1,3-BENZOTHIAZOL-2- AMINE)COBALT(II) COMPLEX.” Қўқон ДПИ. Илмий хабарлар, 8(6), 801-815 (2026). https://doi.org/10.70728/a.series.tab.v08.i06.109
HarvardKhushbokov, Abduvali Bakhodir Ugli, Turayev, Khayit Khudoynazarovich, Umbarov, Ibragim Amonovich, Choriyev, Odil Irgashevich, and Ashurov, Jamshid Mengnorovich (2026) ‘COMPREHENSIVE IN SILICO EVALUATION OF THE PHYSICOCHEMICAL PROPERTIES, PHARMACOKINETIC PROFILE, AND DRUG-LIKENESS OF A NEWLY SYNTHESIZED DICHLOROBIS(6-METHOXY-1,3-BENZOTHIAZOL-2- AMINE)COBALT(II) COMPLEX’, Қўқон ДПИ. Илмий хабарлар, 8(6), 801-815. https://doi.org/10.70728/a.series.tab.v08.i06.109
BibTeX
@article{khushbokovabduvalibakhodirugli2026,
  title = {COMPREHENSIVE IN SILICO EVALUATION OF THE PHYSICOCHEMICAL PROPERTIES, PHARMACOKINETIC PROFILE, AND DRUG-LIKENESS OF A NEWLY SYNTHESIZED DICHLOROBIS(6-METHOXY-1,3-BENZOTHIAZOL-2- AMINE)COBALT(II) COMPLEX},
  author = {Khushbokov, Abduvali Bakhodir Ugli and Turayev, Khayit Khudoynazarovich and Umbarov, Ibragim Amonovich and Choriyev, Odil Irgashevich and Ashurov, Jamshid Mengnorovich},
  journal = {Қўқон ДПИ. Илмий хабарлар},
  year = {2026},
  volume = {8},
  number = {6},
  pages = {801-815},
  doi = {10.70728/a.series.tab.v08.i06.109},
  url = {https://doi.org/10.70728/a.series.tab.v08.i06.109}
}

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