Evaluation of inflammatory cytokine dynamics in women with external genital endometriosis before and after surgery

Atayeva, Farzona Nuriddinovna, Khayitova, Raykhona Tolibovna

Гуманитар ва табиий фанлар журнали · 2025-yil

Annotatsiya

Objective: This study aimed to evaluate the dynamics of inflammatory cytokines in women diagnosed with external genital endometriosis, both before and after surgical intervention.Methods: A cohort of women with histologically confirmed external genital endometriosis underwent laparoscopic surgery. Serum levels of key inflammatory cytokines, including interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-α), and interleukin-1 beta (IL-1β), were measured preoperatively and at various intervals postoperatively using enzyme-linked immunosorbent assay (ELISA). Clinical symptoms and cytokine levels were compared to assess postoperative immune responses and symptom relief.Results: A significant elevation in IL-6, TNF-α, and IL-1β levels was observed preoperatively, correlating with symptom severity. Following surgical treatment, cytokine levels decreased substantially, particularly within the first 3 months post-surgery, aligning with clinical improvement and reduction of pain scores. These findings suggest a marked postoperative reduction in systemic inflammation.Conclusion: Surgical treatment of external genital endometriosis leads to a notable decline in inflammatory cytokine levels, supporting its effectiveness in modulating the inflammatory response associated with the disease. Monitoring cytokine dynamics may offer valuable insights into disease progression and treatment efficacy.

Maqola ma’lumotlari
MualliflarAtayeva, Farzona Nuriddinovna, Khayitova, Raykhona Tolibovna
JurnalГуманитар ва табиий фанлар журнали
NashriyotEMU University
ISSN2026-2027, 2181-4007
Nashr sanasi2025-07-05
Son23
Betlar11-14
TilIngliz
Ilmiy sohaTibbiyot
Indeksga qo‘shilgan2026-08-27

Maqolaning asl sahifasi

Kalit so‘zlar

Endometriosis; External genital endometriosis; Inflammatory cytokines; IL-6; TNF-alpha; IL-1β; Laparoscopic surgery; Immune response; Postoperative outcomes; Chronic pelvic pain.

Ilmiy soha

Tibbiyot

Iqtibos keltirish

APAAtayeva, Farzona Nuriddinovna, & Khayitova, Raykhona Tolibovna (2025). EVALUATION OF INFLAMMATORY CYTOKINE DYNAMICS IN WOMEN WITH EXTERNAL GENITAL ENDOMETRIOSIS BEFORE AND AFTER SURGERY. Гуманитар ва табиий фанлар журнали, (23), 11-14. https://journals.tnmu.uz/index.php/gtfj/article/view/2033
GOST (OAK)Atayeva, Farzona Nuriddinovna, Khayitova, Raykhona Tolibovna EVALUATION OF INFLAMMATORY CYTOKINE DYNAMICS IN WOMEN WITH EXTERNAL GENITAL ENDOMETRIOSIS BEFORE AND AFTER SURGERY // Гуманитар ва табиий фанлар журнали. – 2025. – № 23. – P. 11-14.
MLAAtayeva, Farzona Nuriddinovna, and Khayitova, Raykhona Tolibovna. “EVALUATION OF INFLAMMATORY CYTOKINE DYNAMICS IN WOMEN WITH EXTERNAL GENITAL ENDOMETRIOSIS BEFORE AND AFTER SURGERY.” Гуманитар ва табиий фанлар журнали, (23), 11-14, 2025. https://journals.tnmu.uz/index.php/gtfj/article/view/2033
ChicagoAtayeva, Farzona Nuriddinovna, and Khayitova, Raykhona Tolibovna. “EVALUATION OF INFLAMMATORY CYTOKINE DYNAMICS IN WOMEN WITH EXTERNAL GENITAL ENDOMETRIOSIS BEFORE AND AFTER SURGERY.” Гуманитар ва табиий фанлар журнали, (23), 11-14 (2025). https://journals.tnmu.uz/index.php/gtfj/article/view/2033
HarvardAtayeva, Farzona Nuriddinovna, and Khayitova, Raykhona Tolibovna (2025) ‘EVALUATION OF INFLAMMATORY CYTOKINE DYNAMICS IN WOMEN WITH EXTERNAL GENITAL ENDOMETRIOSIS BEFORE AND AFTER SURGERY’, Гуманитар ва табиий фанлар журнали, (23), 11-14. https://journals.tnmu.uz/index.php/gtfj/article/view/2033
BibTeX
@article{atayevafarzonanuriddinovna2025,
  title = {EVALUATION OF INFLAMMATORY CYTOKINE DYNAMICS IN WOMEN WITH EXTERNAL GENITAL ENDOMETRIOSIS BEFORE AND AFTER SURGERY},
  author = {Atayeva, Farzona Nuriddinovna and Khayitova, Raykhona Tolibovna},
  journal = {Гуманитар ва табиий фанлар журнали},
  year = {2025},
  number = {23},
  pages = {11-14},
  url = {https://journals.tnmu.uz/index.php/gtfj/article/view/2033}
}

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