Relevance. Locoregional recurrence (LRR) of breast cancer (BC) following radical mastectomy presents a significant clinical challenge and is associated with reduced survival. Objective. To assess the risk factors for LRR and develop regional recommendations for effective surveillance and treatment strategies. Materials and methods of the study. A retrospective-prospective analysis of 206 breast cancer patients treated between 2017 and 2024 in the Samarkand region was conducted. The study focused on tumor characteristics, molecular profiles, treatment modalities, recurrence localization, and survival outcomes. Research results. The LRR rate was 5.4%. Most recurrences occurred in women aged 31–50 and in patients with stage IIB–IIIA tumors. Hormone receptor status, HER2 expression, Ki-67 index, and completeness of adjuvant therapy were significant predictors of recurrence. The proposed management algorithm, based on molecular stratification and regional resources, demonstrated potential for improving long-term outcomes. Conclusion. Personalized follow-up and therapy plans based on tumor biology and regional guidelines are essential for reducing recurrence and improving survival in postmastectomy breast cancer patients.
| Mualliflar | Djurayev, Mirjalol, Zaripova, Parvina, Джураев, Миржалол, Зарипова, Парвина, Jo‘rayev, Mirjalol, Zaripova, Parvina |
|---|---|
| Jurnal | Medical science of Uzbekistan / O'zbekiston tibbiyot ilmi |
| Nashr sanasi | 2025-06-28 |
| Jild | 4 |
| Son | 3 |
| Betlar | 09-13 |
| Til | Ingliz |
| DOI | 10.56121/2181-3612-2025-3-09-13 |
DOI: 10.56121/2181-3612-2025-3-09-13 · Maqolaning asl sahifasi
Breast cancer, locoregional recurrence, mastectomy, risk factors, immunohistochemistry, personalized medicine, рак молочной железы, локорегионарный рецидив, мастэктомия, факторы риска, иммуногистохимия, персонализированная медицина, sut bezi saratoni, lokal-regional qaytalanish, mastektomiya, xavf omillari, immunogistokimyo, shaxsiylashtirilgan tibbiyot
Relevance. Breast cancer remains one of the most common and socially significant malignancies among women. Given the high frequency of mastectomies, the risk of locoregional recurrences remains substantial…
The relevance of the problem. Maternal mortality is a pressing problem in the world, and although what is being done has a certain result, it is observed at a high level. The purpose of the study was to investigate…
Relevance: Currently, the role of mobile population groups in preventing the spread of HIV infection among labor migrants is being increasingly studied. Global migration poses a number of challenges for mobile…
The purpose of the study. Determining the share of children with uric nephropathy in the structure of frequently ill children, and studying their social characteristics. Material and research methods. Scientific…
Chronic kidney disease (CKD) is a serious issue in modern healthcare. Numerous studies conducted over the past ten years have shown that the likelihood of cardiovascular diseases (CVD) increases even with a slight…
Relevance. This retrospective study involved the examination of 34 children aged 7 to 14 years suffering from nephrogenic sepsis. Detailed anamnesis data were collected, including physical development indicators…
Relevance. The problem of tuberculosis, as an infectious disease, does not lose its heart against the background of a widespread decrease in tuberculosis. The results of the study indicate the development of borderline…
This article analyzes the molecular-genetic mechanisms underlying the development of salivary gland tumors. Key genetic mutations (PLAG1, HMGA2, CTNNB1) and their impact on tumor growth are examined. The role of…
Introduction. Everolimus, an mTOR inhibitor, has already demonstrated efficacy in endometrial cancer, but experience with its use in Uzbekistan is limited. Resistance to standard therapy often develops in…
Background. Recurrent pregnancy loss (RPL) remains a significant challenge in obstetric practice, impacting the physical and psychological well-being of affected women. Hyperprolactinemia, a common endocrine disorder…
Medical science of Uzbekistan / O'zbekiston tibbiyot ilmi — barcha maqolalar