Locoregional recurrence of breast cancer after radical mastectomy: risk factors, diagnosis, and regional management strategies

Djurayev, Mirjalol, Zaripova, Parvina, Джураев, Миржалол, Зарипова, Парвина, Jo‘rayev, Mirjalol, Zaripova, Parvina

Medical science of Uzbekistan / O'zbekiston tibbiyot ilmi · 2025-yil

Annotatsiya

Relevance. Locoregional recurrence (LRR) of breast cancer (BC) following radical mastectomy presents a significant clinical challenge and is associated with reduced survival. Objective. To assess the risk factors for LRR and develop regional recommendations for effective surveillance and treatment strategies. Materials and methods of the study. A retrospective-prospective analysis of 206 breast cancer patients treated between 2017 and 2024 in the Samarkand region was conducted. The study focused on tumor characteristics, molecular profiles, treatment modalities, recurrence localization, and survival outcomes. Research results. The LRR rate was 5.4%. Most recurrences occurred in women aged 31–50 and in patients with stage IIB–IIIA tumors. Hormone receptor status, HER2 expression, Ki-67 index, and completeness of adjuvant therapy were significant predictors of recurrence. The proposed management algorithm, based on molecular stratification and regional resources, demonstrated potential for improving long-term outcomes. Conclusion. Personalized follow-up and therapy plans based on tumor biology and regional guidelines are essential for reducing recurrence and improving survival in postmastectomy breast cancer patients.

Maqola ma’lumotlari
MualliflarDjurayev, Mirjalol, Zaripova, Parvina, Джураев, Миржалол, Зарипова, Парвина, Jo‘rayev, Mirjalol, Zaripova, Parvina
JurnalMedical science of Uzbekistan / O'zbekiston tibbiyot ilmi
NashriyotАндижон давлат тиббиёт институти
ISSN2181-3612
Nashr sanasi2025-06-28
Jild4
Son3
Betlar09-13
TilIngliz
Ilmiy sohaTibbiyot
DOI10.56121/2181-3612-2025-3-09-13
Indeksga qo‘shilgan2026-08-26

DOI: 10.56121/2181-3612-2025-3-09-13 · Maqolaning asl sahifasi

Kalit so‘zlar

Breast cancer, locoregional recurrence, mastectomy, risk factors, immunohistochemistry, personalized medicine, рак молочной железы, локорегионарный рецидив, мастэктомия, факторы риска, иммуногистохимия, персонализированная медицина, sut bezi saratoni, lokal-regional qaytalanish, mastektomiya, xavf omillari, immunogistokimyo, shaxsiylashtirilgan tibbiyot

Ilmiy soha

Tibbiyot

Iqtibos keltirish

APADjurayev, Mirjalol, Zaripova, Parvina, Джураев, Миржалол, Зарипова, Парвина, Jo‘rayev, Mirjalol, & Zaripova, Parvina (2025). LOCOREGIONAL RECURRENCE OF BREAST CANCER AFTER RADICAL MASTECTOMY: RISK FACTORS, DIAGNOSIS, AND REGIONAL MANAGEMENT STRATEGIES. Medical science of Uzbekistan / O'zbekiston tibbiyot ilmi, 4(3), 09-13. https://doi.org/10.56121/2181-3612-2025-3-09-13
GOST (OAK)Djurayev, Mirjalol va b. LOCOREGIONAL RECURRENCE OF BREAST CANCER AFTER RADICAL MASTECTOMY: RISK FACTORS, DIAGNOSIS, AND REGIONAL MANAGEMENT STRATEGIES // Medical science of Uzbekistan / O'zbekiston tibbiyot ilmi. – 2025. – T. 4, № 3. – P. 09-13. – DOI: 10.56121/2181-3612-2025-3-09-13.
MLADjurayev, Mirjalol, Zaripova, Parvina, Джураев, Миржалол, Зарипова, Парвина, Jo‘rayev, Mirjalol, and Zaripova, Parvina. “LOCOREGIONAL RECURRENCE OF BREAST CANCER AFTER RADICAL MASTECTOMY: RISK FACTORS, DIAGNOSIS, AND REGIONAL MANAGEMENT STRATEGIES.” Medical science of Uzbekistan / O'zbekiston tibbiyot ilmi, 4(3), 09-13, 2025. https://doi.org/10.56121/2181-3612-2025-3-09-13
ChicagoDjurayev, Mirjalol, Zaripova, Parvina, Джураев, Миржалол, Зарипова, Парвина, Jo‘rayev, Mirjalol, and Zaripova, Parvina. “LOCOREGIONAL RECURRENCE OF BREAST CANCER AFTER RADICAL MASTECTOMY: RISK FACTORS, DIAGNOSIS, AND REGIONAL MANAGEMENT STRATEGIES.” Medical science of Uzbekistan / O'zbekiston tibbiyot ilmi, 4(3), 09-13 (2025). https://doi.org/10.56121/2181-3612-2025-3-09-13
HarvardDjurayev, Mirjalol, Zaripova, Parvina, Джураев, Миржалол, Зарипова, Парвина, Jo‘rayev, Mirjalol, and Zaripova, Parvina (2025) ‘LOCOREGIONAL RECURRENCE OF BREAST CANCER AFTER RADICAL MASTECTOMY: RISK FACTORS, DIAGNOSIS, AND REGIONAL MANAGEMENT STRATEGIES’, Medical science of Uzbekistan / O'zbekiston tibbiyot ilmi, 4(3), 09-13. https://doi.org/10.56121/2181-3612-2025-3-09-13
BibTeX
@article{djurayevmirjalol2025,
  title = {LOCOREGIONAL RECURRENCE OF BREAST CANCER AFTER RADICAL MASTECTOMY: RISK FACTORS, DIAGNOSIS, AND REGIONAL MANAGEMENT STRATEGIES},
  author = {Djurayev, Mirjalol and Zaripova, Parvina and Джураев, Миржалол and Зарипова, Парвина and Jo‘rayev, Mirjalol and Zaripova, Parvina},
  journal = {Medical science of Uzbekistan / O'zbekiston tibbiyot ilmi},
  year = {2025},
  volume = {4},
  number = {3},
  pages = {09-13},
  doi = {10.56121/2181-3612-2025-3-09-13},
  url = {https://doi.org/10.56121/2181-3612-2025-3-09-13}
}

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