Clinico-molecular characteristics and therapeutic strategies for locorregional recurrence of breast cancer after surgical intervention

Djurayev, Mirjalol, Zaripova, Parvina, Джураев, Миржалол, Зарипова, Парвина, Jo‘rayev, Mirjalol, Zaripova, Parvina

Medical science of Uzbekistan / O'zbekiston tibbiyot ilmi · 2025-yil

Annotatsiya

Relevance. Breast cancer remains one of the most common and socially significant malignancies among women. Given the high frequency of mastectomies, the risk of locoregional recurrences remains substantial, necessitating the development of effective diagnostic, surveillance, and therapeutic algorithms. Objective. To identify clinical, morphological, and molecular risk factors for breast cancer recurrence and to propose a stratification system and personalized approach to treatment and follow-up. Materials and methods of the study. The study included 206 patients with verified breast cancer who underwent mastectomy. Imaging, immunohistochemical (IHC) typing, and tumor marker monitoring were used. Molecular subtypes, Ki-67 index, and completeness of therapy were assessed. Statistical analysis was performed using the StatTech environment. Research results. A high recurrence risk was found in patients with HER2-positive and triple-negative tumors, stage IIB–IIIA, and high Ki-67 levels. Incomplete adjuvant therapy significantly increased recurrence probability. A follow-up algorithm and risk stratification system were developed. Conclusion. Locoregional breast cancer recurrences are associated with tumor biology and insufficient treatment. Therapy individualization based on IHC profiles improves survival and reduces oncological burden.

Maqola ma’lumotlari
MualliflarDjurayev, Mirjalol, Zaripova, Parvina, Джураев, Миржалол, Зарипова, Парвина, Jo‘rayev, Mirjalol, Zaripova, Parvina
JurnalMedical science of Uzbekistan / O'zbekiston tibbiyot ilmi
NashriyotАндижон давлат тиббиёт институти
ISSN2181-3612
Nashr sanasi2025-06-28
Jild4
Son3
Betlar14-18
TilIngliz
Ilmiy sohaTibbiyot
DOI10.56121/2181-3612-2025-3-14-18
Indeksga qo‘shilgan2026-08-26

DOI: 10.56121/2181-3612-2025-3-14-18 · Maqolaning asl sahifasi

Kalit so‘zlar

breast cancer, mastectomy, recurrence, molecular subtypes, Ki-67, follow-up care, hormone therapy, targeted therapy, рак молочной железы, мастэктомия, рецидив, молекулярные подтипы, Ki-67, диспансерное наблюдение, гормонотерапия, таргетная терапия, sut bezi saratoni, mastektomiya, qaytalanish, molekulyar subtiplar, Ki-67, dispanser kuzatuv, gormon terapiyasi, mo‘ljallangan terapiya

Ilmiy soha

Tibbiyot

Iqtibos keltirish

APADjurayev, Mirjalol, Zaripova, Parvina, Джураев, Миржалол, Зарипова, Парвина, Jo‘rayev, Mirjalol, & Zaripova, Parvina (2025). CLINICO-MOLECULAR CHARACTERISTICS AND THERAPEUTIC STRATEGIES FOR LOCORREGIONAL RECURRENCE OF BREAST CANCER AFTER SURGICAL INTERVENTION. Medical science of Uzbekistan / O'zbekiston tibbiyot ilmi, 4(3), 14-18. https://doi.org/10.56121/2181-3612-2025-3-14-18
GOST (OAK)Djurayev, Mirjalol va b. CLINICO-MOLECULAR CHARACTERISTICS AND THERAPEUTIC STRATEGIES FOR LOCORREGIONAL RECURRENCE OF BREAST CANCER AFTER SURGICAL INTERVENTION // Medical science of Uzbekistan / O'zbekiston tibbiyot ilmi. – 2025. – T. 4, № 3. – P. 14-18. – DOI: 10.56121/2181-3612-2025-3-14-18.
MLADjurayev, Mirjalol, Zaripova, Parvina, Джураев, Миржалол, Зарипова, Парвина, Jo‘rayev, Mirjalol, and Zaripova, Parvina. “CLINICO-MOLECULAR CHARACTERISTICS AND THERAPEUTIC STRATEGIES FOR LOCORREGIONAL RECURRENCE OF BREAST CANCER AFTER SURGICAL INTERVENTION.” Medical science of Uzbekistan / O'zbekiston tibbiyot ilmi, 4(3), 14-18, 2025. https://doi.org/10.56121/2181-3612-2025-3-14-18
ChicagoDjurayev, Mirjalol, Zaripova, Parvina, Джураев, Миржалол, Зарипова, Парвина, Jo‘rayev, Mirjalol, and Zaripova, Parvina. “CLINICO-MOLECULAR CHARACTERISTICS AND THERAPEUTIC STRATEGIES FOR LOCORREGIONAL RECURRENCE OF BREAST CANCER AFTER SURGICAL INTERVENTION.” Medical science of Uzbekistan / O'zbekiston tibbiyot ilmi, 4(3), 14-18 (2025). https://doi.org/10.56121/2181-3612-2025-3-14-18
HarvardDjurayev, Mirjalol, Zaripova, Parvina, Джураев, Миржалол, Зарипова, Парвина, Jo‘rayev, Mirjalol, and Zaripova, Parvina (2025) ‘CLINICO-MOLECULAR CHARACTERISTICS AND THERAPEUTIC STRATEGIES FOR LOCORREGIONAL RECURRENCE OF BREAST CANCER AFTER SURGICAL INTERVENTION’, Medical science of Uzbekistan / O'zbekiston tibbiyot ilmi, 4(3), 14-18. https://doi.org/10.56121/2181-3612-2025-3-14-18
BibTeX
@article{djurayevmirjalol2025,
  title = {CLINICO-MOLECULAR CHARACTERISTICS AND THERAPEUTIC STRATEGIES FOR LOCORREGIONAL RECURRENCE OF BREAST CANCER AFTER SURGICAL INTERVENTION},
  author = {Djurayev, Mirjalol and Zaripova, Parvina and Джураев, Миржалол and Зарипова, Парвина and Jo‘rayev, Mirjalol and Zaripova, Parvina},
  journal = {Medical science of Uzbekistan / O'zbekiston tibbiyot ilmi},
  year = {2025},
  volume = {4},
  number = {3},
  pages = {14-18},
  doi = {10.56121/2181-3612-2025-3-14-18},
  url = {https://doi.org/10.56121/2181-3612-2025-3-14-18}
}

Boshqa maqola uchun iqtibos tayyorlash

Medical science of Uzbekistan / O'zbekiston tibbiyot ilmi jurnalidan boshqa maqolalar

Medical science of Uzbekistan / O'zbekiston tibbiyot ilmi — barcha maqolalar · 2025-yil arxivi

Djurayev, Mirjalol — boshqa maqolalari

Tibbiyot sohasidagi boshqa maqolalar

Tibbiyot sohasidagi OAK jurnallari