Relevance. Breast cancer remains one of the most common and socially significant malignancies among women. Given the high frequency of mastectomies, the risk of locoregional recurrences remains substantial, necessitating the development of effective diagnostic, surveillance, and therapeutic algorithms. Objective. To identify clinical, morphological, and molecular risk factors for breast cancer recurrence and to propose a stratification system and personalized approach to treatment and follow-up. Materials and methods of the study. The study included 206 patients with verified breast cancer who underwent mastectomy. Imaging, immunohistochemical (IHC) typing, and tumor marker monitoring were used. Molecular subtypes, Ki-67 index, and completeness of therapy were assessed. Statistical analysis was performed using the StatTech environment. Research results. A high recurrence risk was found in patients with HER2-positive and triple-negative tumors, stage IIB–IIIA, and high Ki-67 levels. Incomplete adjuvant therapy significantly increased recurrence probability. A follow-up algorithm and risk stratification system were developed. Conclusion. Locoregional breast cancer recurrences are associated with tumor biology and insufficient treatment. Therapy individualization based on IHC profiles improves survival and reduces oncological burden.
| Mualliflar | Djurayev, Mirjalol, Zaripova, Parvina, Джураев, Миржалол, Зарипова, Парвина, Jo‘rayev, Mirjalol, Zaripova, Parvina |
|---|---|
| Jurnal | Medical science of Uzbekistan / O'zbekiston tibbiyot ilmi |
| Nashr sanasi | 2025-06-28 |
| Jild | 4 |
| Son | 3 |
| Betlar | 14-18 |
| Til | Rus |
| DOI | 10.56121/2181-3612-2025-3-14-18 |
DOI: 10.56121/2181-3612-2025-3-14-18 · Maqolaning asl sahifasi
breast cancer, mastectomy, recurrence, molecular subtypes, Ki-67, follow-up care, hormone therapy, targeted therapy, рак молочной железы, мастэктомия, рецидив, молекулярные подтипы, Ki-67, диспансерное наблюдение, гормонотерапия, таргетная терапия, sut bezi saratoni, mastektomiya, qaytalanish, molekulyar subtiplar, Ki-67, dispanser kuzatuv, gormon terapiyasi, mo‘ljallangan terapiya
Relevance: Currently, the role of mobile population groups in preventing the spread of HIV infection among labor migrants is being increasingly studied. Global migration poses a number of challenges for mobile…
Relevance. Locoregional recurrence (LRR) of breast cancer (BC) following radical mastectomy presents a significant clinical challenge and is associated with reduced survival. Objective. To assess the risk factors for…
Chronic kidney disease (CKD) is a serious issue in modern healthcare. Numerous studies conducted over the past ten years have shown that the likelihood of cardiovascular diseases (CVD) increases even with a slight…
The relevance of the problem. Maternal mortality is a pressing problem in the world, and although what is being done has a certain result, it is observed at a high level. The purpose of the study was to investigate…
Relevance. The problem of tuberculosis, as an infectious disease, does not lose its heart against the background of a widespread decrease in tuberculosis. The results of the study indicate the development of borderline…
The purpose of the study. Determining the share of children with uric nephropathy in the structure of frequently ill children, and studying their social characteristics. Material and research methods. Scientific…
Introduction. Everolimus, an mTOR inhibitor, has already demonstrated efficacy in endometrial cancer, but experience with its use in Uzbekistan is limited. Resistance to standard therapy often develops in…
Relevance. This retrospective study involved the examination of 34 children aged 7 to 14 years suffering from nephrogenic sepsis. Detailed anamnesis data were collected, including physical development indicators…
The aim of the study is to consider and evaluate the value of the SCORE-2 cardiovascular risk scale among patients with prediabetes. Material and methods of the study. The study included 45 people aged 40 to 65 years…
This article analyzes the molecular-genetic mechanisms underlying the development of salivary gland tumors. Key genetic mutations (PLAG1, HMGA2, CTNNB1) and their impact on tumor growth are examined. The role of…
Medical science of Uzbekistan / O'zbekiston tibbiyot ilmi — barcha maqolalar