Pathogenesis and molecular-genetic aspects of salivary gland tumors

Rizaev, Jasur, Akhrorov, Alisher, Ризаев, Жасур, Ахроров, Алишер, Rizayev, Jasur, Akhrorov, Alisher

Medical science of Uzbekistan / O'zbekiston tibbiyot ilmi · 2025-yil

Annotatsiya

This article analyzes the molecular-genetic mechanisms underlying the development of salivary gland tumors. Key genetic mutations (PLAG1, HMGA2, CTNNB1) and their impact on tumor growth are examined. The role of dysregulated signaling pathways (Wnt/β-catenin, PI3K/AKT/mTOR, NF-kB) in carcinogenesis is highlighted. Particular attention is given to the expression of molecular markers (CK7, p40, p63, SOX10, S-100) and their diagnostic significance. The influence of chronic inflammation and pro-inflammatory cytokines (IL-6, TNF-α) on tumor progression is discussed. This review underscores the need for further research to develop new diagnostic and therapeutic strategies aimed at identifying molecular targets and improving approaches to the treatment of salivary gland tumors.

Maqola ma’lumotlari
MualliflarRizaev, Jasur, Akhrorov, Alisher, Ризаев, Жасур, Ахроров, Алишер, Rizayev, Jasur, Akhrorov, Alisher
JurnalMedical science of Uzbekistan / O'zbekiston tibbiyot ilmi
NashriyotАндижон давлат тиббиёт институти
ISSN2181-3612
Nashr sanasi2025-04-30
Jild4
Son2
Betlar155-160
TilIngliz
Ilmiy sohaTibbiyot
DOI10.56121/2181-3612-2025-2-155-160
Indeksga qo‘shilgan2026-08-26

DOI: 10.56121/2181-3612-2025-2-155-160 · Maqolaning asl sahifasi

Kalit so‘zlar

salivary gland tumors, molecular-genetic mechanisms, PLAG1, HMGA2, CTNNB1, signaling pathways, Wnt/β-catenin, PI3K/AKT/mTOR, NF-kB, molecular markers, CK7, p40, p63, SOX10, S-100, inflammation, IL-6, TNF-α, опухоли слюнных желез, кулярно-генетические механизмы, PLAG1, HMGA2, CTNNB1, сигнальные пути, Wnt/β-катенин, PI3K/AKT/mTOR, NF-kB, молекулярные маркеры, CK7, p40, p63, SOX10, S-100, воспаление, IL-6, TNF-α, so‘la bezlari o‘simtalari, molekulyar-genetik mexanizmlar, PLAG1, HMGA2, CTNNB1, signalli yo‘llar, Wnt/β-katenin, PI3K/AKT/mTOR, NF-kB, molekulyar markerlar, CK7, p40, p63, SOX10, S-100, yallig‘lanish, IL-6, TNF-α

Ilmiy soha

Tibbiyot

Iqtibos keltirish

APARizaev, Jasur, Akhrorov, Alisher, Ризаев, Жасур, Ахроров, Алишер, Rizayev, Jasur, & Akhrorov, Alisher (2025). PATHOGENESIS AND MOLECULAR-GENETIC ASPECTS OF SALIVARY GLAND TUMORS. Medical science of Uzbekistan / O'zbekiston tibbiyot ilmi, 4(2), 155-160. https://doi.org/10.56121/2181-3612-2025-2-155-160
GOST (OAK)Rizaev, Jasur va b. PATHOGENESIS AND MOLECULAR-GENETIC ASPECTS OF SALIVARY GLAND TUMORS // Medical science of Uzbekistan / O'zbekiston tibbiyot ilmi. – 2025. – T. 4, № 2. – P. 155-160. – DOI: 10.56121/2181-3612-2025-2-155-160.
MLARizaev, Jasur, Akhrorov, Alisher, Ризаев, Жасур, Ахроров, Алишер, Rizayev, Jasur, and Akhrorov, Alisher. “PATHOGENESIS AND MOLECULAR-GENETIC ASPECTS OF SALIVARY GLAND TUMORS.” Medical science of Uzbekistan / O'zbekiston tibbiyot ilmi, 4(2), 155-160, 2025. https://doi.org/10.56121/2181-3612-2025-2-155-160
ChicagoRizaev, Jasur, Akhrorov, Alisher, Ризаев, Жасур, Ахроров, Алишер, Rizayev, Jasur, and Akhrorov, Alisher. “PATHOGENESIS AND MOLECULAR-GENETIC ASPECTS OF SALIVARY GLAND TUMORS.” Medical science of Uzbekistan / O'zbekiston tibbiyot ilmi, 4(2), 155-160 (2025). https://doi.org/10.56121/2181-3612-2025-2-155-160
HarvardRizaev, Jasur, Akhrorov, Alisher, Ризаев, Жасур, Ахроров, Алишер, Rizayev, Jasur, and Akhrorov, Alisher (2025) ‘PATHOGENESIS AND MOLECULAR-GENETIC ASPECTS OF SALIVARY GLAND TUMORS’, Medical science of Uzbekistan / O'zbekiston tibbiyot ilmi, 4(2), 155-160. https://doi.org/10.56121/2181-3612-2025-2-155-160
BibTeX
@article{rizaevjasur2025,
  title = {PATHOGENESIS AND MOLECULAR-GENETIC ASPECTS OF SALIVARY GLAND TUMORS},
  author = {Rizaev, Jasur and Akhrorov, Alisher and Ризаев, Жасур and Ахроров, Алишер and Rizayev, Jasur and Akhrorov, Alisher},
  journal = {Medical science of Uzbekistan / O'zbekiston tibbiyot ilmi},
  year = {2025},
  volume = {4},
  number = {2},
  pages = {155-160},
  doi = {10.56121/2181-3612-2025-2-155-160},
  url = {https://doi.org/10.56121/2181-3612-2025-2-155-160}
}

Boshqa maqola uchun iqtibos tayyorlash

Medical science of Uzbekistan / O'zbekiston tibbiyot ilmi jurnalidan boshqa maqolalar

Medical science of Uzbekistan / O'zbekiston tibbiyot ilmi — barcha maqolalar · 2025-yil arxivi

Rizaev, Jasur — boshqa maqolalari

Tibbiyot sohasidagi boshqa maqolalar

Tibbiyot sohasidagi OAK jurnallari