Comparison of the effectiveness of the original and generic forms of clopidogrel in patients with coronary artery disease (CAD).4o

Муллабаева , Г, Хайруллаев , У, Mullabaeva , Guzal, Xairullaev , Umid, Mullabaeva , Guzal, Khairullaev , Umid

O‘zbekiston кardiologiyasi · 2025-yil

Annotatsiya

Background. To evaluate the antiaggregation activity and clinical tolerability of Areplex (75 mg, ADAMED, Poland) compared to Plavix (75 mg, Sanofi-Winthrop Industrie, France) in CAD patients. Materials and methods. A blinded, randomized, two-parallel-group study included 40 patients with stable angina (FC I-IV). Platelet aggregation was assessed using the AP 2110 analyzer (SOLAR) with ADP (5 µmol/L) and arachidonic acid (0.5 mg/mL) inducers after a 300 mg loading dose. Results. At 24 hours post-dose, both groups showed significant reductions in aggregation degree and rate (p<0.05), with no intergroup differences (p>0.05). Safety profiles were comparable, with no adverse events reported. Conclusion. Areplex demonstrated bioequivalence to Plavix, with good tolerability, supporting its use as an effective antiplatelet agent in CAD patients.

Maqola ma’lumotlari
MualliflarМуллабаева , Г, Хайруллаев , У, Mullabaeva , Guzal, Xairullaev , Umid, Mullabaeva , Guzal, Khairullaev , Umid
JurnalO‘zbekiston кardiologiyasi
NashriyotЎзбекистон кардиологлар ассоциацияси
ISSN3060-4850
Nashr sanasi2025-03-30
Jild2
Son1
Betlar4-10
TilIngliz
Ilmiy sohaTibbiyot
DOI10.70626/cardiouz-2025-2-00032
Indeksga qo‘shilgan2026-08-26

DOI: 10.70626/cardiouz-2025-2-00032 · Maqolaning asl sahifasi

Kalit so‘zlar

bioequivalence, clopidogrel, areplex, plavix, coronary artery disease, antiplatelet therapy, биоэквивалентность, клопидогрель, ареплекс, плавикс, ишемическая болезнь сердца, антиагрегантная терапия, bioekvivalentlik, klopidogrel, areplex, plavix, yurak ishemik kasalligi, antiaggregatsion davolash

Ilmiy soha

Tibbiyot

Iqtibos keltirish

APAМуллабаева , Г, Хайруллаев , У, Mullabaeva , Guzal, Xairullaev , Umid, Mullabaeva , Guzal, & Khairullaev , Umid (2025). Comparison of the effectiveness of the original and generic forms of clopidogrel in patients with coronary artery disease (CAD).4o. O‘zbekiston кardiologiyasi, 2(1), 4-10. https://doi.org/10.70626/cardiouz-2025-2-00032
GOST (OAK)Муллабаева , Г va b. Comparison of the effectiveness of the original and generic forms of clopidogrel in patients with coronary artery disease (CAD).4o // O‘zbekiston кardiologiyasi. – 2025. – T. 2, № 1. – P. 4-10. – DOI: 10.70626/cardiouz-2025-2-00032.
MLAМуллабаева , Г, Хайруллаев , У, Mullabaeva , Guzal, Xairullaev , Umid, Mullabaeva , Guzal, and Khairullaev , Umid. “Comparison of the effectiveness of the original and generic forms of clopidogrel in patients with coronary artery disease (CAD).4o.” O‘zbekiston кardiologiyasi, 2(1), 4-10, 2025. https://doi.org/10.70626/cardiouz-2025-2-00032
ChicagoМуллабаева , Г, Хайруллаев , У, Mullabaeva , Guzal, Xairullaev , Umid, Mullabaeva , Guzal, and Khairullaev , Umid. “Comparison of the effectiveness of the original and generic forms of clopidogrel in patients with coronary artery disease (CAD).4o.” O‘zbekiston кardiologiyasi, 2(1), 4-10 (2025). https://doi.org/10.70626/cardiouz-2025-2-00032
HarvardМуллабаева , Г, Хайруллаев , У, Mullabaeva , Guzal, Xairullaev , Umid, Mullabaeva , Guzal, and Khairullaev , Umid (2025) ‘Comparison of the effectiveness of the original and generic forms of clopidogrel in patients with coronary artery disease (CAD).4o’, O‘zbekiston кardiologiyasi, 2(1), 4-10. https://doi.org/10.70626/cardiouz-2025-2-00032
BibTeX
@article{article2025,
  title = {Comparison of the effectiveness of the original and generic forms of clopidogrel in patients with coronary artery disease (CAD).4o},
  author = {Муллабаева , Г and Хайруллаев , У and Mullabaeva , Guzal and Xairullaev , Umid and Mullabaeva , Guzal and Khairullaev , Umid},
  journal = {O‘zbekiston кardiologiyasi},
  year = {2025},
  volume = {2},
  number = {1},
  pages = {4-10},
  doi = {10.70626/cardiouz-2025-2-00032},
  url = {https://doi.org/10.70626/cardiouz-2025-2-00032}
}

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