Background. To evaluate the antiaggregation activity and clinical tolerability of Areplex (75 mg, ADAMED, Poland) compared to Plavix (75 mg, Sanofi-Winthrop Industrie, France) in CAD patients. Materials and methods. A blinded, randomized, two-parallel-group study included 40 patients with stable angina (FC I-IV). Platelet aggregation was assessed using the AP 2110 analyzer (SOLAR) with ADP (5 µmol/L) and arachidonic acid (0.5 mg/mL) inducers after a 300 mg loading dose. Results. At 24 hours post-dose, both groups showed significant reductions in aggregation degree and rate (p<0.05), with no intergroup differences (p>0.05). Safety profiles were comparable, with no adverse events reported. Conclusion. Areplex demonstrated bioequivalence to Plavix, with good tolerability, supporting its use as an effective antiplatelet agent in CAD patients.
| Mualliflar | Муллабаева , Г, Хайруллаев , У, Mullabaeva , Guzal, Xairullaev , Umid, Mullabaeva , Guzal, Khairullaev , Umid |
|---|---|
| Jurnal | O‘zbekiston кardiologiyasi |
| Nashr sanasi | 2025-03-30 |
| Jild | 2 |
| Son | 1 |
| Betlar | 4-10 |
| Til | Rus |
| DOI | 10.70626/cardiouz-2025-2-00032 |
DOI: 10.70626/cardiouz-2025-2-00032 · Maqolaning asl sahifasi
bioequivalence, clopidogrel, areplex, plavix, coronary artery disease, antiplatelet therapy, биоэквивалентность, клопидогрель, ареплекс, плавикс, ишемическая болезнь сердца, антиагрегантная терапия, bioekvivalentlik, klopidogrel, areplex, plavix, yurak ishemik kasalligi, antiaggregatsion davolash
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