Aim: We evaluated the influence of sacubitril/valsartan on the left ventricle function and clinical status of patients with heart failure and a reduced ejection fraction. Materials and methods: From 2018 to 2020, patients cured with 50-200 mg sacubitril/valsartan after coronary bypass grafting or coronary stenting for ischemic heart disease and HFrEF (aged 54-70 years) were enrolled in this prospective study. Results: There was no death case. There was a female prevalence with female to male ratio of 1,7:1. the value of ejection fraction high significantly increased (p=0,035), whereas the indices of left ventricle end-diastolic volume (p=0,015) and end-diastolic volume index (p=0,022) as well as left ventricle mass index were high significantly decreased (p=0,001) that indicate the amelioration of left ventricle systolic function. Correspondingly, the clinical status of all patients improved according to New York Heart Association Class (p=0,001). Conclusion: The post-CABG or PCI patients with HFrEF should be cured with sacubitril/valsartan basing on its implementation instruction. Nevertheless, future studies should focus on a larger cohort of post-CABG or PCI patients to compare the effectiveness and safety of sacubitril/valsartan usage raising from its adverse event in comparison to conventional therapy.
| Mualliflar | Adilova , Ikbol, Akbarova , Gulnoza, Адилова , Икбол, Акбарова , Гулноза, Адилова , Иқбол, Акбарова , Гулноза |
|---|---|
| Jurnal | Жамият ва инновациялар / Общество и инновации / Society and innovations |
| Nashr sanasi | 2021-05-20 |
| Jild | 2 |
| Son | 4/S |
| Betlar | 746-752 |
| Til | Ingliz |
| DOI | 10.47689/2181-1415-vol2-iss4/s-pp746-752 |
DOI: 10.47689/2181-1415-vol2-iss4/s-pp746-752 · Maqolaning asl sahifasi
сакубутрил/валсартан, неприлизин, сниженная фракция выброса, сердечная недостаточность, левый желудочек, sacubitril/valsartan, neprilysin, reduced ejection fraction, heart failure, left ventricle, сакубутрил/валсартан, неприлизин, пасайган қискариш фракцияси, юрак етишмовчилиги, чап қоринча
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