Effective influence of sacubutril/valsartan on systolic function of left ventricle in patients with heart failure and a reduced ejеction fraction

Adilova , Ikbol, Akbarova , Gulnoza, Адилова , Икбол, Акбарова , Гулноза, Адилова , Иқбол, Акбарова , Гулноза

Жамият ва инновациялар / Общество и инновации / Society and innovations · 2021-yil

Annotatsiya

Aim: We evaluated the influence of sacubitril/valsartan on the left ventricle function and clinical status of patients with heart failure and a reduced ejection fraction. Materials and methods: From 2018 to 2020, patients cured with 50-200 mg sacubitril/valsartan after coronary bypass grafting or coronary stenting for ischemic heart disease and HFrEF (aged 54-70 years) were enrolled in this prospective study. Results: There was no death case. There was a female prevalence with female to male ratio of 1,7:1. the value of ejection fraction high significantly increased (p=0,035), whereas the indices of left ventricle end-diastolic volume (p=0,015) and end-diastolic volume index (p=0,022) as well as left ventricle mass index were high significantly decreased (p=0,001) that indicate the amelioration of left ventricle systolic function. Correspondingly, the clinical status of all patients improved according to New York Heart Association Class (p=0,001). Conclusion: The post-CABG or PCI patients with HFrEF should be cured with sacubitril/valsartan basing on its implementation instruction. Nevertheless, future studies should focus on a larger cohort of post-CABG or PCI patients to compare the effectiveness and safety of sacubitril/valsartan usage raising from its adverse event in comparison to conventional therapy.

Maqola ma’lumotlari
MualliflarAdilova , Ikbol, Akbarova , Gulnoza, Адилова , Икбол, Акбарова , Гулноза, Адилова , Иқбол, Акбарова , Гулноза
JurnalЖамият ва инновациялар / Общество и инновации / Society and innovations
NashriyotIn Science МЧЖ
ISSN2181-1415
Nashr sanasi2021-05-20
Jild2
Son4/S
Betlar746-752
TilIngliz
Ilmiy sohaTibbiyot
DOI10.47689/2181-1415-vol2-iss4/s-pp746-752
Indeksga qo‘shilgan2026-08-26

DOI: 10.47689/2181-1415-vol2-iss4/s-pp746-752 · Maqolaning asl sahifasi

Kalit so‘zlar

сакубутрил/валсартан, неприлизин, сниженная фракция выброса, сердечная недостаточность, левый желудочек, sacubitril/valsartan, neprilysin, reduced ejection fraction, heart failure, left ventricle, сакубутрил/валсартан, неприлизин, пасайган қискариш фракцияси, юрак етишмовчилиги, чап қоринча

Ilmiy soha

Tibbiyot

Iqtibos keltirish

APAAdilova , Ikbol, Akbarova , Gulnoza, Адилова , Икбол, Акбарова , Гулноза, Адилова , Иқбол, & Акбарова , Гулноза (2021). Effective influence of sacubutril/valsartan on systolic function of left ventricle in patients with heart failure and a reduced ejеction fraction. Жамият ва инновациялар / Общество и инновации / Society and innovations, 2(4/S), 746-752. https://doi.org/10.47689/2181-1415-vol2-iss4/s-pp746-752
GOST (OAK)Adilova , Ikbol va b. Effective influence of sacubutril/valsartan on systolic function of left ventricle in patients with heart failure and a reduced ejеction fraction // Жамият ва инновациялар / Общество и инновации / Society and innovations. – 2021. – T. 2, № 4/S. – P. 746-752. – DOI: 10.47689/2181-1415-vol2-iss4/s-pp746-752.
MLAAdilova , Ikbol, Akbarova , Gulnoza, Адилова , Икбол, Акбарова , Гулноза, Адилова , Иқбол, and Акбарова , Гулноза. “Effective influence of sacubutril/valsartan on systolic function of left ventricle in patients with heart failure and a reduced ejеction fraction.” Жамият ва инновациялар / Общество и инновации / Society and innovations, 2(4/S), 746-752, 2021. https://doi.org/10.47689/2181-1415-vol2-iss4/s-pp746-752
ChicagoAdilova , Ikbol, Akbarova , Gulnoza, Адилова , Икбол, Акбарова , Гулноза, Адилова , Иқбол, and Акбарова , Гулноза. “Effective influence of sacubutril/valsartan on systolic function of left ventricle in patients with heart failure and a reduced ejеction fraction.” Жамият ва инновациялар / Общество и инновации / Society and innovations, 2(4/S), 746-752 (2021). https://doi.org/10.47689/2181-1415-vol2-iss4/s-pp746-752
HarvardAdilova , Ikbol, Akbarova , Gulnoza, Адилова , Икбол, Акбарова , Гулноза, Адилова , Иқбол, and Акбарова , Гулноза (2021) ‘Effective influence of sacubutril/valsartan on systolic function of left ventricle in patients with heart failure and a reduced ejеction fraction’, Жамият ва инновациялар / Общество и инновации / Society and innovations, 2(4/S), 746-752. https://doi.org/10.47689/2181-1415-vol2-iss4/s-pp746-752
BibTeX
@article{adilovaikbol2021,
  title = {Effective influence of sacubutril/valsartan on systolic function of left ventricle in patients with heart failure and a reduced ejеction fraction},
  author = {Adilova , Ikbol and Akbarova , Gulnoza and Адилова , Икбол and Акбарова , Гулноза and Адилова , Иқбол and Акбарова , Гулноза},
  journal = {Жамият ва инновациялар / Общество и инновации / Society and innovations},
  year = {2021},
  volume = {2},
  number = {4/S},
  pages = {746-752},
  doi = {10.47689/2181-1415-vol2-iss4/s-pp746-752},
  url = {https://doi.org/10.47689/2181-1415-vol2-iss4/s-pp746-752}
}

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