Modulating effect of crambe kotschyana extract on the metabolic-functional state of the liver in rats with experimental thyrotoxicosis

Yusupova Iroda Muxammadraximovna, Нарбутаева Дилдора Абдусаматовна, Арипова Салима Фазыловна, Артикова Дилфуза Махаматовна, Исламова Жаннат Икрамовна

Марказий Осиё эндокринологик журнали · 2026-yil

Annotatsiya

The thyroid gland and liver are intricately interrelated under both physiological and pathological conditions. Liver pathology in thyrotoxicosis is quite common (15–79%) and manifests as increased serum activity of cytolytic and/or cholestatic enzymes. The aim of the study was to study the metabolic and functional state of the liver in animals with experimental thyrotoxicosis against the background of the administration of Crambe kotschyana Boiss extract in comparison with mercazolil. Materials and methods: Male rats (160-180 g) with thyrotoxicosis induced by oral administration of levothyroxine sodium at a dose of 50 mcg/kg were used in the experiment. Levels of free triiodothyronine, free tetraiodothyronine, and thyroid-stimulating hormone were determined in the animals' blood serum, as well as the activity of alanine and aspartate aminotransferase enzymes, alkaline phosphatase and the total protein content, the content of glycogen and malondialdehyde was determined in the liver tissue. Results: Experimental thyrotoxicosis was accompanied by severe hepatic dysfunction. This was confirmed by a significant increase in ALT, AST, and alkaline phosphatase activity, an increase in MDA levels, and a decrease in glycogen and total protein levels, reflecting the development of cytolysis, cholestasis, and increased oxidative stress. Under these conditions, Crambe kotschyana extract had a milder and more physiological effect on liver tissue, more effectively reduced the manifestations of oxidative stress and contributed to better restoration of liver energy reserves compared to mercazolil, which, despite partial correction of the disorders caused by thyrotoxicosis, showed its own hepatotoxicity. Conclusion: The obtained data show pronounced liver disorders under thyrogenic hypermetabolic load and allow us to compare the corrective effects of C.kotschyana extract with the traditional thyreostatic agent, mercazolil.

Maqola ma’lumotlari
MualliflarYusupova Iroda Muxammadraximovna, Нарбутаева Дилдора Абдусаматовна, Арипова Салима Фазыловна, Артикова Дилфуза Махаматовна, Исламова Жаннат Икрамовна
JurnalМарказий Осиё эндокринологик журнали
NashriyotРеспублика ихтисослаштирилган эндокринология илмий-амалий тиббиёт маркази
ISSN2181-3426
Nashr sanasi2026-06-27
Jild6
Son2
TilIngliz
Ilmiy sohaTibbiyot
Indeksga qo‘shilgan2026-08-26

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Kalit so‘zlar

экспериментальный тиреотоксикоз, экстракт Сrambe кotschyana, мерказолил, гепатодисфункция, experimental thyrotoxicosis, Crambe kotschyana extract, mercazolil, hepatodysfunction, экспериментальный тиреотоксикоз, экстракт Сrambe кotschyana, мерказолил, гепатодисфункция

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APAYusupova Iroda Muxammadraximovna, Нарбутаева Дилдора Абдусаматовна, Арипова Салима Фазыловна, Артикова Дилфуза Махаматовна, & Исламова Жаннат Икрамовна (2026). MODULATING EFFECT OF CRAMBE KOTSCHYANA EXTRACT ON THE METABOLIC-FUNCTIONAL STATE OF THE LIVER IN RATS WITH EXPERIMENTAL THYROTOXICOSIS. Марказий Осиё эндокринологик журнали, 6(2). https://www.tadqiqot.uz/index.php/cae/article/view/14389
GOST (OAK)Yusupova Iroda Muxammadraximovna va b. MODULATING EFFECT OF CRAMBE KOTSCHYANA EXTRACT ON THE METABOLIC-FUNCTIONAL STATE OF THE LIVER IN RATS WITH EXPERIMENTAL THYROTOXICOSIS // Марказий Осиё эндокринологик журнали. – 2026. – T. 6, № 2.
MLAYusupova Iroda Muxammadraximovna, Нарбутаева Дилдора Абдусаматовна, Арипова Салима Фазыловна, Артикова Дилфуза Махаматовна, and Исламова Жаннат Икрамовна. “MODULATING EFFECT OF CRAMBE KOTSCHYANA EXTRACT ON THE METABOLIC-FUNCTIONAL STATE OF THE LIVER IN RATS WITH EXPERIMENTAL THYROTOXICOSIS.” Марказий Осиё эндокринологик журнали, 6(2), 2026. https://www.tadqiqot.uz/index.php/cae/article/view/14389
ChicagoYusupova Iroda Muxammadraximovna, Нарбутаева Дилдора Абдусаматовна, Арипова Салима Фазыловна, Артикова Дилфуза Махаматовна, and Исламова Жаннат Икрамовна. “MODULATING EFFECT OF CRAMBE KOTSCHYANA EXTRACT ON THE METABOLIC-FUNCTIONAL STATE OF THE LIVER IN RATS WITH EXPERIMENTAL THYROTOXICOSIS.” Марказий Осиё эндокринологик журнали, 6(2) (2026). https://www.tadqiqot.uz/index.php/cae/article/view/14389
HarvardYusupova Iroda Muxammadraximovna, Нарбутаева Дилдора Абдусаматовна, Арипова Салима Фазыловна, Артикова Дилфуза Махаматовна, and Исламова Жаннат Икрамовна (2026) ‘MODULATING EFFECT OF CRAMBE KOTSCHYANA EXTRACT ON THE METABOLIC-FUNCTIONAL STATE OF THE LIVER IN RATS WITH EXPERIMENTAL THYROTOXICOSIS’, Марказий Осиё эндокринологик журнали, 6(2). https://www.tadqiqot.uz/index.php/cae/article/view/14389
BibTeX
@article{yusupovairodamuxammadraximovna2026,
  title = {MODULATING EFFECT OF CRAMBE KOTSCHYANA EXTRACT ON THE METABOLIC-FUNCTIONAL STATE OF THE LIVER IN RATS WITH EXPERIMENTAL THYROTOXICOSIS},
  author = {Yusupova Iroda Muxammadraximovna and Нарбутаева Дилдора Абдусаматовна and Арипова Салима Фазыловна and Артикова Дилфуза Махаматовна and Исламова Жаннат Икрамовна},
  journal = {Марказий Осиё эндокринологик журнали},
  year = {2026},
  volume = {6},
  number = {2},
  url = {https://www.tadqiqot.uz/index.php/cae/article/view/14389}
}

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