Today, premature ovarian failure (POF) is one of the most difficult problems of women's health. Relevance. As the main cause of infertility, a decrease in the quality of life of women with POI is a problem that needs special attention. After a confirmed diagnosis, there are currently no methods to restore ovarian function and fertility. The spread of the COVID-19 virus and pandemic-related quarantine measures have led to women's mental health and menstrual irregularities, up to and including amenorrhea. Therefore, it is important to identify risk factors for the development of POI at an earlier stage. Purpose. To evaluate the plasma concentration of KISS1 and BDNF in patients with POI that developed after coronavirus infection. Materials and methods. A survey of 52 patients with POI, after undergoing COVID-19 and 32 healthy women, aged 18 to 40 years with a regular menstrual cycle, was carried out. The blood concentrations of kisspeptin (HUMAN KISS1) and BDNF (Human BDNF) were studied using the Human Elisa Kit in the laboratory of RSSPMCE. Statistical analysis was performed using Minitab 14. Results. In women with POI, developed after coronavirus infection the level of KISS1 was significantly lower (251.70±7.27 pg/ml, p<0.05) than in healthy women (439.91±8.41 pg/ml, p< 0.05). The BDNF concentration was also lower in the first group (232.82±7.29 pg/ml, p<0.05) than in healthy women (428.59±7.22 pg/ml, p<0.05). Serum levels of KISS1 and BDNF are negatively correlated with stress severity. Conclusion. We can say that kisspeptin and BDNF play an important role not only in women's reproductive health, but also in their mental state. Stress due to the coronavirus pandemic, reducing the level of KISS1 and BDNF in the blood can lead to the development of premature ovarian failure. This observation brings important potential insight into the pathogenesis of POI.
| Mualliflar | Бакоева Н.М., Хайдарова Ф.А. |
|---|---|
| Jurnal | Марказий Осиё эндокринологик журнали |
| Nashr sanasi | 2023-05-13 |
| Jild | 3 |
| Son | 1 |
| Til | Rus |
преждевременная недостаточность яичников, КОВИД-19, стресс, KISS1, BDNF, premature ovarian insufficiency, COVID-19, stress, KISS1, BDNF, tuxumdonlarning muddatidan ilgari yetishmovchili, KOVID-19, stress, KISS1, DBNF
Obesity is a chronic and relapsing disease that not only disrupts metabolism, but is also a risk factor for cardiovascular disease. Although behavioral therapy is important in treating obesity, it is difficult to reach…
To study the incidence of postoperative complications in patients with transsphenoidal pituitary adenoectomy
In review paper, the authors presented data about anatomy and physiology of parathyroid glands, molecular mechanism of parathyroid hormone action, interaction with vitamin D, its derivatives and receptors, also…
Хронический синусит (ХС) является широко распространенным и часто рецидивирующим заболеванием околоносовых пазух, природа и механизм которых окончательно не выяснены (С.В. Сирак, А.А. Слетов, М.В. Локтионова и др…
Cardiovascular disease (CVD) is the world's leading cause of death, and obesity is a recognized risk factor for cardiovascular disease. Early detection and treatment of cardiovascular disease is critical to reducing the…
Согласно данным ВОЗ, распространённость ожирения становится все больше. Ожирение стало одной из глобальных эпидемий, возникающее в любом возрасте. Регуляция массы тела в организме осуществляется через комплексное…
Background. The current COVID-19 pandemic shows that there is a two-way interaction between diabetes mellitus (DM) and the 2019 coronavirus disease, COVID-19. On the one hand, people with diabetes are at higher risk of…
Особенности развития амиодарон-индуцированной дисфункции щитовидной железы (ЩЖ) зависящие от выраженности дефицита йода в популяции и особенностей выборки пациентов продолжают оставаться в центре дискуссии.
Objective. Studying the prevalence of diabetes mellitus (DM) is necessary to assess the epidemiological situation in the region Aim. To study the prevalence of DM in the Republic of Karakalpakstan. Methods. The source…
The purpose of the study is to perform a comparative characteristic of electroneuromiographic studies of patients with diabetic neuropathy at the stage of late complications Material and research methods. A simple…