«Особенности гормональных и иммуннологических нарушений у пациентов с аутоиммунным полигландулярным синдромом»

Халимова З.Ю, Негматова Г.Ш

Марказий Осиё эндокринологик журнали · 2022-yil

Annotatsiya

The aim of investigation is to evaluate the clinical and biochemical and immunological characteristics of patients with autoimmune polyglandular syndrome (APS) type 2. Material and research methods. 258 patients were selected with an APS 2 of the type with the defeat of the endocrine glands. The following 3 subgroups of patients are formed: 1 gr. : with diabetes mellitus type 1 (DM 1)- 30 persons, 1b gr. - patients with primary adrenal insufficiency (PAI) - 32, 1B G. - patients with autoimmune thyroiditis (AIT) - 56 patients. All studies that included generally clinical, biochemical, hormonal (ACTH, TSH, Cortisol, DHEA, insulin, free thyroxine), immunological research and ECG, ultrasound of internal organs, X-ray studies, consultation of narrow specialists, as well as statistical Methods performed all 188 patients. Immunological research methods included the determination in the blood of antibodies (AT) to the thyroid gland (AT TPO), to the adrenal glands (AT toN), to the pancreas (antibodies of glutamine acid decarboxylase (GAD / IA-2)), gender glands, antibodies to P450S21. Research results. Patients prevailed in the age category from 18 to 44 years old, both among men and women - 58/35 cases, respectively. As our studies have shown, serum levels of the CRH, the Russian Federation, MK and ATCCP in the group of patients with rheumatoid arthritis were significantly elevated in comparison with the control group In patients with 1 A groups, the average levels of GAD / IA-2 were significantly elevated 16.7 ± 1.09 me / ml (p <0.05). The study of antibodies to P450S21 in the 1B group showed that the antibodies to P450C21 were detected in 23 (72%). In patients 1 in groups, the level of AT TPO was 26.8 ± 2.02 me / ml and was reliably clarified (p <0 05). The study of antibodies to P450C21 in patients with PAI showed that antibodies to P450C21 were detected in 23 (72%) patients with PAI. In the comparison group in patients with CHNN tuberculosis genesis, the antibody to P450S21 was not detected. Conclusions. 1. The immunological study of patients with autoimmune polyglandular syndrome is important in the early diagnosis of DM type1, AIT, and PAI diagnosis, in the individual assessment of the patient's compensation degree and should be included in the General Protocol for the conduct of patients in this category. The study of antibodies to P450S21 in the etiological diagnosis of PAI has a high diagnostic value, especially in the differential diagnosis of PAI tuberculosis genesis. Введение. AПС представляет собой редкую полиэндокринопатию, характеризующуюся отказом нескольких желез внутренней секреции, а также неэндокринных органов, вызванной иммуноопосредованным разрушением тканей [5-8]. Это обычно приводит к гипофункциональному состоянию [11].

Maqola ma’lumotlari
MualliflarХалимова З.Ю, Негматова Г.Ш
JurnalМарказий Осиё эндокринологик журнали
NashriyotРеспублика ихтисослаштирилган эндокринология илмий-амалий тиббиёт маркази
ISSN2181-3426
Nashr sanasi2022-12-23
Jild2
Son2
TilRus
Ilmiy sohaTibbiyot
Indeksga qo‘shilgan2026-09-13

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APAХалимова З.Ю, & Негматова Г.Ш (2022). «ОСОБЕННОСТИ ГОРМОНАЛЬНЫХ И ИММУННОЛОГИЧЕСКИХ НАРУШЕНИЙ У ПАЦИЕНТОВ С АУТОИММУННЫМ ПОЛИГЛАНДУЛЯРНЫМ СИНДРОМОМ». Марказий Осиё эндокринологик журнали, 2(2). https://www.tadqiqot.uz/index.php/cae/article/view/6159
GOST (OAK)Халимова З.Ю, Негматова Г.Ш «ОСОБЕННОСТИ ГОРМОНАЛЬНЫХ И ИММУННОЛОГИЧЕСКИХ НАРУШЕНИЙ У ПАЦИЕНТОВ С АУТОИММУННЫМ ПОЛИГЛАНДУЛЯРНЫМ СИНДРОМОМ» // Марказий Осиё эндокринологик журнали. – 2022. – T. 2, № 2.
MLAХалимова З.Ю, and Негматова Г.Ш. “«ОСОБЕННОСТИ ГОРМОНАЛЬНЫХ И ИММУННОЛОГИЧЕСКИХ НАРУШЕНИЙ У ПАЦИЕНТОВ С АУТОИММУННЫМ ПОЛИГЛАНДУЛЯРНЫМ СИНДРОМОМ».” Марказий Осиё эндокринологик журнали, 2(2), 2022. https://www.tadqiqot.uz/index.php/cae/article/view/6159
ChicagoХалимова З.Ю, and Негматова Г.Ш. “«ОСОБЕННОСТИ ГОРМОНАЛЬНЫХ И ИММУННОЛОГИЧЕСКИХ НАРУШЕНИЙ У ПАЦИЕНТОВ С АУТОИММУННЫМ ПОЛИГЛАНДУЛЯРНЫМ СИНДРОМОМ».” Марказий Осиё эндокринологик журнали, 2(2) (2022). https://www.tadqiqot.uz/index.php/cae/article/view/6159
HarvardХалимова З.Ю, and Негматова Г.Ш (2022) ‘«ОСОБЕННОСТИ ГОРМОНАЛЬНЫХ И ИММУННОЛОГИЧЕСКИХ НАРУШЕНИЙ У ПАЦИЕНТОВ С АУТОИММУННЫМ ПОЛИГЛАНДУЛЯРНЫМ СИНДРОМОМ»’, Марказий Осиё эндокринологик журнали, 2(2). https://www.tadqiqot.uz/index.php/cae/article/view/6159
BibTeX
@article{article2022,
  title = {«ОСОБЕННОСТИ ГОРМОНАЛЬНЫХ И ИММУННОЛОГИЧЕСКИХ НАРУШЕНИЙ У ПАЦИЕНТОВ С АУТОИММУННЫМ ПОЛИГЛАНДУЛЯРНЫМ СИНДРОМОМ»},
  author = {Халимова З.Ю and Негматова Г.Ш},
  journal = {Марказий Осиё эндокринологик журнали},
  year = {2022},
  volume = {2},
  number = {2},
  url = {https://www.tadqiqot.uz/index.php/cae/article/view/6159}
}

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