Relevance. The effect of a healthy lifestyle on modifiable risk factors of atherosclerosis has the best results. However, it is not always sufficient, then it is necessary to use anti-atherosclerotic drugs, preferably from herbal raw materials. ladyginozid, being a herbal preparation, has an antiatherosclerotic property, causing an increase in morphofunctional activity of the thyroid gland. Aim: to study the effect of ladyginoside on the morphofunctional state of the thyroid gland. Materials and methods. The experimental design included experiments on 38 rabbits, divided into an experimental group of 28, in which animals received ladyginozid at a dose of 10 mg/kg weight for 30, 60 and 90 days. 10 constituted the control group. The status of the thyroid gland was studied by morphometric measurement of thyrocyte nuclei and karyograms. Statistical processing of the data was carried out using analysis of variance with calculation and subsequent analysis of the strength of the influence of the ladyginozid factor on the functional morphology of the thyroid gland. Results. The descriptive data of the study indicate that the karyogram of the experimental group of animals, as compared with that of the control, was markedly shifted to the right and acquired a two-tailed shape by increasing the number of large nuclei from 116.65 to 163.02 μm3. Moda shifted from class to class with volume ranging from 51.97 to 72.63 µm3. Nuclei appeared as early as 30 days of the experiment, which were not found in the control group. Conclusions. The results of the investigation, taking into account modern morphometric methods of the thyroid gland, morphofunctional state estimation, show that ladyginozid at the 30 and 60 days of the experiment increases the gland activity, that by the end of the experiment at 90 days approaches to the control animal values, at the same time high values of the follicular epithelium cells nuclear volume testify to persistence of the organ morphofunctional activity increased.
| Mualliflar | Дон А.Н |
|---|---|
| Jurnal | Марказий Осиё эндокринологик журнали |
| Nashr sanasi | 2022-12-23 |
| Jild | 2 |
| Son | 2 |
| Til | Rus |
Фактор, риска, здоровый, образ, жизни, ладыгинозид, Omil, xavf, sog'lom turmush tarzi, ladiginozid., Factor, risk, healthy, lifestyle, ladyginoside
The purpose of the study is to study the clinical, biochemical and hormonal characteristics of patients with of Charcot foot. Material and research methods. The object of the study was 200 patients with DM 2…
Background and Aims: Arterial stiffness is associated with increased risk for targetorgan damage, cardiovascular events and overall mortality in the general population, patients with diabetes mellitus and patients with…
The purpose of the study is to study the central hemodynamic characteristics of patients with DM type 2 and cardio-renal syndrome.(CRS) Material and research methods. The research material is represented by an analysis…
Obesity and overweight are one of the growing global public health problems. Recently, interest in it has increased significantly, due to the high prevalence of obesity among all age groups of the population, especially…
The purpose of the study is to study the effectiveness of Sandostatin – Lar in the treatment of giant pituitary adenoma. Material and research methods. We studied the data of the 3x centers of Tashkent (RSSPMC…
The goal is to study the value of the quality indicators of the quality of life and the brain neurotrophic factor of BDNF in patients with type 2 diabetes mellitus (DM2), complicated by chronic kidney disease (CKD) and…
It is important to note that 5% of the total number of patients with Turner syndrome have mosaicism in the presence of the Y chromosome (45,X/46,XY) or translocation of a section of the Y chromosome (SRY or DYS14 gene)…
Relevance: Female infertility is an urgent problem in all countries of the world. The preservation and restoration of women's reproductive health is the most important medical task of national importance, the successful…
The purpose of the study is to study the results of ultrasound dopplerography of the heart in patients with a neuroichemic form of diabetic foot syndrome (DFS) associated with coronary heart disease (CHD) Material and…
This article provides information on the prevalence of diabetes mellitus and prediabetes, bout the high compatibility of diabetes mellitus and cardiovascular pathology, about the high mortality rate of patients with…