Vascular rigidity in patients with type 2 diabetes mellitus AT different stages of diabetic nephropathy

Тураев Ф.Ф, Алиханова Н.М, Мусаханова Ч.Б, Назарова Н.С, Тахирова Ф.А, Аббосходжаева Л.С, Акрамова Г.Г, Шакирова М.М, Каюмова Д.Т, Айходжаева М.А, Максутова Н.Н, Тригулова Р.Х, Давронов Р.Р

Марказий Осиё эндокринологик журнали · 2022-yil

Annotatsiya

Background and Aims: Arterial stiffness is associated with increased risk for targetorgan damage, cardiovascular events and overall mortality in the general population, patients with diabetes mellitus and patients with chronic kidney disease (CKD) of all stages. The aim of this study is assessment of vascular stiffness and endothelial function in patients with type 2 diabetes at different stages of diabetic nephropathy and without it. Materials and methods. We examined 155 patients with DM2 aged 18 to 70 years, received planned inpatient treatment at the RSNPMC of Endocrinology named after Academician Ya.Kh. Turakulova. The criterion for forming groups is the stage of diabetic nephropathy. Control group consisted of 33 patients without diabetic nephropathy. In addition to routine tests for the diagnosis of CKD, sphygmography (measurement of pulse wave velocity (PWV)) and central (aortic) BP) were performed using the SphygmoCor XCEL device (AtCor Medical, Sydney, Australia). Informed consent was obtaining from each patient prior to the study. Results. Spearman's correlation analysis revealed a significant relationship between the pulse wave velocity - PWV, the age of the subjects (CC=0.379; r=0.000) and the duration of diabetes (CC=0.211; r=0.015). In patients with DM2 in the control group, these indicators averaged 8.4±1.5, and in patients of the main group, on average, 9.89±2.4; a significant increase in PWV was found with increasing severity of CKD (CC=3.72, r =0.004). However, no dependence of PWV indices on the level of glycemic compensation was found (CC=-0.081; p=0.367). Discussion. Diabetic CKD patients present higher arterial stiffness than non-CKD counterparts. Increase in the stiffness of the arteries, the progression of DN may be an early marker of macrovascular lesions even in patients without hyperlipidemia.

Maqola ma’lumotlari
MualliflarТураев Ф.Ф, Алиханова Н.М, Мусаханова Ч.Б, Назарова Н.С, Тахирова Ф.А, Аббосходжаева Л.С, Акрамова Г.Г, Шакирова М.М, Каюмова Д.Т, Айходжаева М.А, Максутова Н.Н, Тригулова Р.Х, Давронов Р.Р
JurnalМарказий Осиё эндокринологик журнали
NashriyotРеспублика ихтисослаштирилган эндокринология илмий-амалий тиббиёт маркази
ISSN2181-3426
Nashr sanasi2022-12-23
Jild2
Son2
TilIngliz
Ilmiy sohaTibbiyot
Indeksga qo‘shilgan2026-09-13

Maqolaning asl sahifasi

Kalit so‘zlar

: сахарный диабет, хроническая болезнь почек, скоростью пульсовой волны, артериальная жесткость, Қандли диабет, буйрак сурункали касаллиги, пульс тўлқинининг тезлиги, артериал қаттиқлик., diabetes mellitus, chronic kidney disease, pulse wave velocity, arterial stiffness

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Tibbiyot

Iqtibos keltirish

APAТураев Ф.Ф, Алиханова Н.М, Мусаханова Ч.Б, Назарова Н.С, Тахирова Ф.А, Аббосходжаева Л.С, Акрамова Г.Г, Шакирова М.М, Каюмова Д.Т, Айходжаева М.А, Максутова Н.Н, Тригулова Р.Х, & Давронов Р.Р (2022). VASCULAR RIGIDITY IN PATIENTS WITH TYPE 2 DIABETES MELLITUS AT DIFFERENT STAGES OF DIABETIC NEPHROPATHY. Марказий Осиё эндокринологик журнали, 2(2). https://www.tadqiqot.uz/index.php/cae/article/view/6145
GOST (OAK)Тураев Ф.Ф va b. VASCULAR RIGIDITY IN PATIENTS WITH TYPE 2 DIABETES MELLITUS AT DIFFERENT STAGES OF DIABETIC NEPHROPATHY // Марказий Осиё эндокринологик журнали. – 2022. – T. 2, № 2.
MLAТураев Ф.Ф, Алиханова Н.М, Мусаханова Ч.Б, Назарова Н.С, Тахирова Ф.А, Аббосходжаева Л.С, Акрамова Г.Г, Шакирова М.М, Каюмова Д.Т, Айходжаева М.А, Максутова Н.Н, Тригулова Р.Х, and Давронов Р.Р. “VASCULAR RIGIDITY IN PATIENTS WITH TYPE 2 DIABETES MELLITUS AT DIFFERENT STAGES OF DIABETIC NEPHROPATHY.” Марказий Осиё эндокринологик журнали, 2(2), 2022. https://www.tadqiqot.uz/index.php/cae/article/view/6145
ChicagoТураев Ф.Ф, Алиханова Н.М, Мусаханова Ч.Б, Назарова Н.С, Тахирова Ф.А, Аббосходжаева Л.С, Акрамова Г.Г, Шакирова М.М, Каюмова Д.Т, Айходжаева М.А, Максутова Н.Н, Тригулова Р.Х, and Давронов Р.Р. “VASCULAR RIGIDITY IN PATIENTS WITH TYPE 2 DIABETES MELLITUS AT DIFFERENT STAGES OF DIABETIC NEPHROPATHY.” Марказий Осиё эндокринологик журнали, 2(2) (2022). https://www.tadqiqot.uz/index.php/cae/article/view/6145
HarvardТураев Ф.Ф, Алиханова Н.М, Мусаханова Ч.Б, Назарова Н.С, Тахирова Ф.А, Аббосходжаева Л.С, Акрамова Г.Г, Шакирова М.М, Каюмова Д.Т, Айходжаева М.А, Максутова Н.Н, Тригулова Р.Х, and Давронов Р.Р (2022) ‘VASCULAR RIGIDITY IN PATIENTS WITH TYPE 2 DIABETES MELLITUS AT DIFFERENT STAGES OF DIABETIC NEPHROPATHY’, Марказий Осиё эндокринологик журнали, 2(2). https://www.tadqiqot.uz/index.php/cae/article/view/6145
BibTeX
@article{article2022,
  title = {VASCULAR RIGIDITY IN PATIENTS WITH TYPE 2 DIABETES MELLITUS AT DIFFERENT STAGES OF DIABETIC NEPHROPATHY},
  author = {Тураев Ф.Ф and Алиханова Н.М and Мусаханова Ч.Б and Назарова Н.С and Тахирова Ф.А and Аббосходжаева Л.С and Акрамова Г.Г and Шакирова М.М and Каюмова Д.Т and Айходжаева М.А and Максутова Н.Н and Тригулова Р.Х and Давронов Р.Р},
  journal = {Марказий Осиё эндокринологик журнали},
  year = {2022},
  volume = {2},
  number = {2},
  url = {https://www.tadqiqot.uz/index.php/cae/article/view/6145}
}

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