Correction of depressive disorders and evaluation of the effectiveness of comprehensive rehabilitation in patients with chemical addictive disorders

OCHILOV Ulug’bek Usmanovich, TURAYEV Bobir Temirpulotovich, SULTANOV Shoxrux Xabibullayevich

Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali · 2026-yil

Annotatsiya

Purpose: Identification of depressive disorders in patients with chemical addictive disorders and enhancement of the effectiveness of the rehabilitation process through their management. Material and methods: The study was conducted in 2024–2025 at the Samarkand branch of the Republican Specialized Scientific-Practical Medical Center for Mental Health. Based on clinical and psychometric assessments, 200 patients diagnosed with psychoactive substance dependence and having chemical addictive disorders were studied. Among them, 61% had alcohol dependence, 24% opioid dependence, 9% synthetic cannabinoid use, and 6% psychostimulant dependence. Patients with depressive symptoms were randomly divided into two groups: the main group (n=100) received a combined approach (SSRI + Cognitive Behavioral Therapy (CBT) + Motivational Interviewing (MI)), while the comparison group (n=100) received only SSRI treatment. Depressive symptoms were assessed using HDRS, BDI, and HADS scales. Evaluation was conducted at three stages: before rehabilitation, after 3 months, and at a 6-month follow-up. Results: The main group showed a significant reduction in depressive symptoms across all scales: BDI scores decreased from 25,1 ± 3,0 to 8,4 ± 1,9, HDRS from 27,8 ± 4,3 to 7,9 ± 2,2, and HADS depression subscale from 13,8 ± 2,0 to 4,4 ± 1,1 (p < 0,001). While improvement was also observed in the comparison group, the changes were significantly less pronounced (p < 0,005). Conclusion: In patients with chemical addictive disorders, a comprehensive (pharmacological and psychotherapeutic) approach is more effective in correcting depressive disorders and ensures a higher-quality and more stable rehabilitation process.

Maqola ma’lumotlari
MualliflarOCHILOV Ulug’bek Usmanovich, TURAYEV Bobir Temirpulotovich, SULTANOV Shoxrux Xabibullayevich
JurnalJournal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali
NashriyotТошкент давлат стоматалогия институти, , «Expert Lawyers» MЧЖ
ISSN2181-9300
Nashr sanasi2026-04-21
Jild11
Son1
TilIngliz
Ilmiy sohaTibbiyot
Indeksga qo‘shilgan2026-08-27

Maqolaning asl sahifasi

Kalit so‘zlar

химическое аддиктивное расстройство, психоактивные вещества, зависимость, депрессия, реабилитация, когнитивно-поведенческая терапия, мотивационное интервьюирование, ИОЗС, chemical addictive disorder, psychoactive substance, dependence, depression, rehabilitation, cognitive behavioral therapy, motivational interviewing, SSRI, kimyoviy addiktiv buzilish, psixoaktiv modda, qaramlik, depressiya, reabilitatsiya, kognitiv xulq-atvor terapiyasi, motivatsion intervyu, SSRI

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Iqtibos keltirish

APAOCHILOV Ulug’bek Usmanovich, TURAYEV Bobir Temirpulotovich, & SULTANOV Shoxrux Xabibullayevich (2026). CORRECTION OF DEPRESSIVE DISORDERS AND EVALUATION OF THE EFFECTIVENESS OF COMPREHENSIVE REHABILITATION IN PATIENTS WITH CHEMICAL ADDICTIVE DISORDERS. Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali, 11(1). https://tadqiqot.uz/index.php/biomedicine/article/view/13464
GOST (OAK)OCHILOV Ulug’bek Usmanovich, TURAYEV Bobir Temirpulotovich, SULTANOV Shoxrux Xabibullayevich CORRECTION OF DEPRESSIVE DISORDERS AND EVALUATION OF THE EFFECTIVENESS OF COMPREHENSIVE REHABILITATION IN PATIENTS WITH CHEMICAL ADDICTIVE DISORDERS // Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali. – 2026. – T. 11, № 1.
MLAOCHILOV Ulug’bek Usmanovich, TURAYEV Bobir Temirpulotovich, and SULTANOV Shoxrux Xabibullayevich. “CORRECTION OF DEPRESSIVE DISORDERS AND EVALUATION OF THE EFFECTIVENESS OF COMPREHENSIVE REHABILITATION IN PATIENTS WITH CHEMICAL ADDICTIVE DISORDERS.” Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali, 11(1), 2026. https://tadqiqot.uz/index.php/biomedicine/article/view/13464
ChicagoOCHILOV Ulug’bek Usmanovich, TURAYEV Bobir Temirpulotovich, and SULTANOV Shoxrux Xabibullayevich. “CORRECTION OF DEPRESSIVE DISORDERS AND EVALUATION OF THE EFFECTIVENESS OF COMPREHENSIVE REHABILITATION IN PATIENTS WITH CHEMICAL ADDICTIVE DISORDERS.” Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali, 11(1) (2026). https://tadqiqot.uz/index.php/biomedicine/article/view/13464
HarvardOCHILOV Ulug’bek Usmanovich, TURAYEV Bobir Temirpulotovich, and SULTANOV Shoxrux Xabibullayevich (2026) ‘CORRECTION OF DEPRESSIVE DISORDERS AND EVALUATION OF THE EFFECTIVENESS OF COMPREHENSIVE REHABILITATION IN PATIENTS WITH CHEMICAL ADDICTIVE DISORDERS’, Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali, 11(1). https://tadqiqot.uz/index.php/biomedicine/article/view/13464
BibTeX
@article{ochilovulugbekusmanovich2026,
  title = {CORRECTION OF DEPRESSIVE DISORDERS AND EVALUATION OF THE EFFECTIVENESS OF COMPREHENSIVE REHABILITATION IN PATIENTS WITH CHEMICAL ADDICTIVE DISORDERS},
  author = {OCHILOV Ulug’bek Usmanovich and TURAYEV Bobir Temirpulotovich and SULTANOV Shoxrux Xabibullayevich},
  journal = {Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali},
  year = {2026},
  volume = {11},
  number = {1},
  url = {https://tadqiqot.uz/index.php/biomedicine/article/view/13464}
}

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