Differences in hormone receptor status between primary and secondary tumor nodules in multifocal breast cancer

NORBEKOVA Munira Khamrokulovna, ALIMKHODZHAYEVA Lola Telmanovna, OTAJONOV Jamoliddin Khusanovich, ZIYAVEDENOVA Soniyakhon Saidaalo kizi, KHUSANOVA Mohinabonu Jamoliddinovna, MIRZAYEVA Matluba Akbarali kizi

Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali · 2025-yil

Annotatsiya

The aim of the study: To analyze the molecular-biological characteristics of primary and secondary tumors in patients with breast cancer (BC). Material and methods: A retrospective analysis of data from 133 patients treated at the Republican Specialized Scientific and Practical Center of Oncology and Radiology and its branches during 2018-2023 was conducted. Histological and immunohistochemical analyses were performed. Results: When immunohistochemical (IHC) analysis was performed on the primary and secondary tumor nodules, it was confirmed that in cases where ER and PR receptors were not detected in the primary nodule, hormone receptors were positive in the secondary nodule. (p-0.05) Conclusion: If hormone receptors are negative in the primary nodule, it is recommended to perform IHC analysis on the secondary nodule. This is a factor that determines the possibility of including hormone therapy in treatment programs.

Maqola ma’lumotlari
MualliflarNORBEKOVA Munira Khamrokulovna, ALIMKHODZHAYEVA Lola Telmanovna, OTAJONOV Jamoliddin Khusanovich, ZIYAVEDENOVA Soniyakhon Saidaalo kizi, KHUSANOVA Mohinabonu Jamoliddinovna, MIRZAYEVA Matluba Akbarali kizi
JurnalJournal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali
NashriyotТошкент давлат стоматалогия институти, , «Expert Lawyers» MЧЖ
ISSN2181-9300
Nashr sanasi2025-09-08
Jild10
Son3/2
TilIngliz
Ilmiy sohaTibbiyot
Indeksga qo‘shilgan2026-08-27

Maqolaning asl sahifasi

Kalit so‘zlar

multicentric, multifocal, breast cancer, histological examination, immunohistochemistry, hormone receptors, multisentrik, ko’p o’choqli, sut bezi saratoni, gistologik tekshiruv, immunogistokimyo, gormon retseptorlari

Ilmiy soha

Tibbiyot

Iqtibos keltirish

APANORBEKOVA Munira Khamrokulovna, ALIMKHODZHAYEVA Lola Telmanovna, OTAJONOV Jamoliddin Khusanovich, ZIYAVEDENOVA Soniyakhon Saidaalo kizi, KHUSANOVA Mohinabonu Jamoliddinovna, & MIRZAYEVA Matluba Akbarali kizi (2025). DIFFERENCES IN HORMONE RECEPTOR STATUS BETWEEN PRIMARY AND SECONDARY TUMOR NODULES IN MULTIFOCAL BREAST CANCER. Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali, 10(3/2). https://tadqiqot.uz/index.php/biomedicine/article/view/12281
GOST (OAK)NORBEKOVA Munira Khamrokulovna va b. DIFFERENCES IN HORMONE RECEPTOR STATUS BETWEEN PRIMARY AND SECONDARY TUMOR NODULES IN MULTIFOCAL BREAST CANCER // Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali. – 2025. – T. 10, № 3/2.
MLANORBEKOVA Munira Khamrokulovna, ALIMKHODZHAYEVA Lola Telmanovna, OTAJONOV Jamoliddin Khusanovich, ZIYAVEDENOVA Soniyakhon Saidaalo kizi, KHUSANOVA Mohinabonu Jamoliddinovna, and MIRZAYEVA Matluba Akbarali kizi. “DIFFERENCES IN HORMONE RECEPTOR STATUS BETWEEN PRIMARY AND SECONDARY TUMOR NODULES IN MULTIFOCAL BREAST CANCER.” Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali, 10(3/2), 2025. https://tadqiqot.uz/index.php/biomedicine/article/view/12281
ChicagoNORBEKOVA Munira Khamrokulovna, ALIMKHODZHAYEVA Lola Telmanovna, OTAJONOV Jamoliddin Khusanovich, ZIYAVEDENOVA Soniyakhon Saidaalo kizi, KHUSANOVA Mohinabonu Jamoliddinovna, and MIRZAYEVA Matluba Akbarali kizi. “DIFFERENCES IN HORMONE RECEPTOR STATUS BETWEEN PRIMARY AND SECONDARY TUMOR NODULES IN MULTIFOCAL BREAST CANCER.” Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali, 10(3/2) (2025). https://tadqiqot.uz/index.php/biomedicine/article/view/12281
HarvardNORBEKOVA Munira Khamrokulovna, ALIMKHODZHAYEVA Lola Telmanovna, OTAJONOV Jamoliddin Khusanovich, ZIYAVEDENOVA Soniyakhon Saidaalo kizi, KHUSANOVA Mohinabonu Jamoliddinovna, and MIRZAYEVA Matluba Akbarali kizi (2025) ‘DIFFERENCES IN HORMONE RECEPTOR STATUS BETWEEN PRIMARY AND SECONDARY TUMOR NODULES IN MULTIFOCAL BREAST CANCER’, Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali, 10(3/2). https://tadqiqot.uz/index.php/biomedicine/article/view/12281
BibTeX
@article{norbekovamunirakhamrokulovna2025,
  title = {DIFFERENCES IN HORMONE RECEPTOR STATUS BETWEEN PRIMARY AND SECONDARY TUMOR NODULES IN MULTIFOCAL BREAST CANCER},
  author = {NORBEKOVA Munira Khamrokulovna and ALIMKHODZHAYEVA Lola Telmanovna and OTAJONOV Jamoliddin Khusanovich and ZIYAVEDENOVA Soniyakhon Saidaalo kizi and KHUSANOVA Mohinabonu Jamoliddinovna and MIRZAYEVA Matluba Akbarali kizi},
  journal = {Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali},
  year = {2025},
  volume = {10},
  number = {3/2},
  url = {https://tadqiqot.uz/index.php/biomedicine/article/view/12281}
}

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