Neurological aspects of chronic cerebral ischemia

MADJIDOVA Yakutkhan Nabievna, NIZAMHODJAEVA Shakhzoda Bakhdiyor qizi, AZIMOVA Nodira Mirvasitovna, BOTIROVA Zebo Khasan qizi

Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali · 2025-yil

Annotatsiya

Chronic cerebral ischemia is a progressively developing impairment of cerebral blood circulation that leads to diffuse or small focal damage to brain tissue. This condition is accompanied by characteristic neurological and cognitive disorders [2]. The pathological process is based on an imbalance between intensified oxidative processes and insufficient activity of the brain’s antioxidant systems, which leads to the development of sustained oxidative stress [4,6]. Cerebral blood flow disorders provoke disruptions in energy metabolism, manifested in mitochondrial dysfunction and impaired endothelial function of blood vessels [5,6]. These pathological changes contribute to damage to both small and large vessels, with clinical manifestations depending on the stage of the disease and including increased fatigue, impaired thinking processes, various psychoneurological symptoms, and focal neurological deficits. The earliest and most significant diagnostic sign is cognitive impairment, which is often accompanied by emotional disturbances and tends to progressively worsen. Thus, chronic cerebral ischemia is a complex pathological process based on impaired cerebral perfusion, metabolic disturbances, and structural changes in the blood vessels, all of which together determine the typical clinical picture of this disease [2,3,5]. One of the contributing factors in the development of endothelial dysfunction in chronic cerebral ischemia (CCI) is an increased level of homocysteine in blood plasma. Hyperhomocysteinemia is associated with an increased risk of vascular catastrophes and is an independent risk factor for cognitive impairment in patients with CCI [1,2,5,6].

Maqola ma’lumotlari
MualliflarMADJIDOVA Yakutkhan Nabievna, NIZAMHODJAEVA Shakhzoda Bakhdiyor qizi, AZIMOVA Nodira Mirvasitovna, BOTIROVA Zebo Khasan qizi
JurnalJournal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali
NashriyotТошкент давлат стоматалогия институти, , «Expert Lawyers» MЧЖ
ISSN2181-9300
Nashr sanasi2025-09-08
Jild10
Son3/2
TilIngliz
Ilmiy sohaTibbiyot
Indeksga qo‘shilgan2026-08-27

Maqolaning asl sahifasi

Kalit so‘zlar

хроническая ишемия головного мозга, мозговое кровообращение, когнитивные нарушения, окислительный стресс, эндотелиальная дисфункция, гомоцистеин, нейродегенерация, chronic cerebral ischemia, cerebral blood flow, cognitive impairment, oxidative stress, endothelial dysfunction, homocysteine, neurodegeneration, сурункали мия ишемияси, мия қон айланиши, когнитив бузилишлар, оксидловчи стресс, эндотелий дисфункцияси, гомоцистеин, нейродегенерация

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Iqtibos keltirish

APAMADJIDOVA Yakutkhan Nabievna, NIZAMHODJAEVA Shakhzoda Bakhdiyor qizi, AZIMOVA Nodira Mirvasitovna, & BOTIROVA Zebo Khasan qizi (2025). NEUROLOGICAL ASPECTS OF CHRONIC CEREBRAL ISCHEMIA. Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali, 10(3/2). https://tadqiqot.uz/index.php/biomedicine/article/view/12279
GOST (OAK)MADJIDOVA Yakutkhan Nabievna va b. NEUROLOGICAL ASPECTS OF CHRONIC CEREBRAL ISCHEMIA // Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali. – 2025. – T. 10, № 3/2.
MLAMADJIDOVA Yakutkhan Nabievna, NIZAMHODJAEVA Shakhzoda Bakhdiyor qizi, AZIMOVA Nodira Mirvasitovna, and BOTIROVA Zebo Khasan qizi. “NEUROLOGICAL ASPECTS OF CHRONIC CEREBRAL ISCHEMIA.” Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali, 10(3/2), 2025. https://tadqiqot.uz/index.php/biomedicine/article/view/12279
ChicagoMADJIDOVA Yakutkhan Nabievna, NIZAMHODJAEVA Shakhzoda Bakhdiyor qizi, AZIMOVA Nodira Mirvasitovna, and BOTIROVA Zebo Khasan qizi. “NEUROLOGICAL ASPECTS OF CHRONIC CEREBRAL ISCHEMIA.” Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali, 10(3/2) (2025). https://tadqiqot.uz/index.php/biomedicine/article/view/12279
HarvardMADJIDOVA Yakutkhan Nabievna, NIZAMHODJAEVA Shakhzoda Bakhdiyor qizi, AZIMOVA Nodira Mirvasitovna, and BOTIROVA Zebo Khasan qizi (2025) ‘NEUROLOGICAL ASPECTS OF CHRONIC CEREBRAL ISCHEMIA’, Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali, 10(3/2). https://tadqiqot.uz/index.php/biomedicine/article/view/12279
BibTeX
@article{madjidovayakutkhannabievna2025,
  title = {NEUROLOGICAL ASPECTS OF CHRONIC CEREBRAL ISCHEMIA},
  author = {MADJIDOVA Yakutkhan Nabievna and NIZAMHODJAEVA Shakhzoda Bakhdiyor qizi and AZIMOVA Nodira Mirvasitovna and BOTIROVA Zebo Khasan qizi},
  journal = {Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali},
  year = {2025},
  volume = {10},
  number = {3/2},
  url = {https://tadqiqot.uz/index.php/biomedicine/article/view/12279}
}

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