Chronic cerebral ischemia is a progressively developing impairment of cerebral blood circulation that leads to diffuse or small focal damage to brain tissue. This condition is accompanied by characteristic neurological and cognitive disorders [2]. The pathological process is based on an imbalance between intensified oxidative processes and insufficient activity of the brain’s antioxidant systems, which leads to the development of sustained oxidative stress [4,6]. Cerebral blood flow disorders provoke disruptions in energy metabolism, manifested in mitochondrial dysfunction and impaired endothelial function of blood vessels [5,6]. These pathological changes contribute to damage to both small and large vessels, with clinical manifestations depending on the stage of the disease and including increased fatigue, impaired thinking processes, various psychoneurological symptoms, and focal neurological deficits. The earliest and most significant diagnostic sign is cognitive impairment, which is often accompanied by emotional disturbances and tends to progressively worsen. Thus, chronic cerebral ischemia is a complex pathological process based on impaired cerebral perfusion, metabolic disturbances, and structural changes in the blood vessels, all of which together determine the typical clinical picture of this disease [2,3,5]. One of the contributing factors in the development of endothelial dysfunction in chronic cerebral ischemia (CCI) is an increased level of homocysteine in blood plasma. Hyperhomocysteinemia is associated with an increased risk of vascular catastrophes and is an independent risk factor for cognitive impairment in patients with CCI [1,2,5,6].
| Mualliflar | MADJIDOVA Yakutkhan Nabievna, NIZAMHODJAEVA Shakhzoda Bakhdiyor qizi, AZIMOVA Nodira Mirvasitovna, BOTIROVA Zebo Khasan qizi |
|---|---|
| Jurnal | Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali |
| Nashr sanasi | 2025-09-08 |
| Jild | 10 |
| Son | 3/2 |
| Til | Rus |
хроническая ишемия головного мозга, мозговое кровообращение, когнитивные нарушения, окислительный стресс, эндотелиальная дисфункция, гомоцистеин, нейродегенерация, chronic cerebral ischemia, cerebral blood flow, cognitive impairment, oxidative stress, endothelial dysfunction, homocysteine, neurodegeneration, сурункали мия ишемияси, мия қон айланиши, когнитив бузилишлар, оксидловчи стресс, эндотелий дисфункцияси, гомоцистеин, нейродегенерация
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