The role of molecular medicine in predicting the course and outcome of chronic pyelonephritis in children

GAPPAROVA Guli Nurmuminovna

Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali · 2025-yil

Annotatsiya

Objective: To determine the level of KIM-1 excretion in urine in groups of patients with chronic pyelonephritis, as well as to assess the possibility of using KIM-1 as a criterion for predicting the clinical course of the disease. Methods: The study included 43 children aged 7-17 years with chronic pyelonephritis. Depending on the objectives set, a range of clinical, epidemiological, biochemical and statistical methods were used in conducting scientific research. Results: In patients of group 1 (n-21), edema syndrome of varying severity and localization was observed, proteinuria was 579,0 mg/day with a single dose, hypoalbuminemia, erythrocyturia. In addition, patients in group 1 showed decreased renal function. In group 2 (n-22), daily proteinuria was 282±4.85 mg/day, erythrocyturia did not exceed 5000 in 1 ml according to the Nechiporenko method. The level of KIM-1 in patients of group 1 was 9,59 ng/ml (p <0.001). In patients of group 2, KIM-1 was 1,56 ng/ml. Conclusions. It has been shown that determination of KIM-1 in urine is an accessible and non-invasive method for early detection of hypoxic, toxic or microbial damage to the renal parenchyma, improving the quality of diagnostics. Another benefit of testing the KIM-1 biomarker in urine is that it reduces the complications, side effects and stress associated with taking blood samples from a child and helps improve the child's quality of life.

Maqola ma’lumotlari
MualliflarGAPPAROVA Guli Nurmuminovna
JurnalJournal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali
NashriyotТошкент давлат стоматалогия институти, , «Expert Lawyers» MЧЖ
ISSN2181-9300
Nashr sanasi2025-08-09
Jild10
Son3/1
TilIngliz
Ilmiy sohaTibbiyot
Indeksga qo‘shilgan2026-08-27

Maqolaning asl sahifasi

Kalit so‘zlar

KIM-1, цистатин C, СКФ, хронический пиелонефрит, дети, лейкоцитурия, протеинурия., KIM-1, cystatin C, GFR, chronic pyelonephritis, children, leukocyturia, proteinuria., KIM-1, sistatin C, KFT, surunkali piyelonefrit, bolalar, leykosituriya, proteinuriya.

Ilmiy soha

Tibbiyot

Iqtibos keltirish

APAGAPPAROVA Guli Nurmuminovna (2025). THE ROLE OF MOLECULAR MEDICINE IN PREDICTING THE COURSE AND OUTCOME OF CHRONIC PYELONEPHRITIS IN CHILDREN. Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali, 10(3/1). https://tadqiqot.uz/index.php/biomedicine/article/view/12047
GOST (OAK)GAPPAROVA Guli Nurmuminovna THE ROLE OF MOLECULAR MEDICINE IN PREDICTING THE COURSE AND OUTCOME OF CHRONIC PYELONEPHRITIS IN CHILDREN // Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali. – 2025. – T. 10, № 3/1.
MLAGAPPAROVA Guli Nurmuminovna. “THE ROLE OF MOLECULAR MEDICINE IN PREDICTING THE COURSE AND OUTCOME OF CHRONIC PYELONEPHRITIS IN CHILDREN.” Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali, 10(3/1), 2025. https://tadqiqot.uz/index.php/biomedicine/article/view/12047
ChicagoGAPPAROVA Guli Nurmuminovna. “THE ROLE OF MOLECULAR MEDICINE IN PREDICTING THE COURSE AND OUTCOME OF CHRONIC PYELONEPHRITIS IN CHILDREN.” Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali, 10(3/1) (2025). https://tadqiqot.uz/index.php/biomedicine/article/view/12047
HarvardGAPPAROVA Guli Nurmuminovna (2025) ‘THE ROLE OF MOLECULAR MEDICINE IN PREDICTING THE COURSE AND OUTCOME OF CHRONIC PYELONEPHRITIS IN CHILDREN’, Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali, 10(3/1). https://tadqiqot.uz/index.php/biomedicine/article/view/12047
BibTeX
@article{gapparovagulinurmuminovna2025,
  title = {THE ROLE OF MOLECULAR MEDICINE IN PREDICTING THE COURSE AND OUTCOME OF CHRONIC PYELONEPHRITIS IN CHILDREN},
  author = {GAPPAROVA Guli Nurmuminovna},
  journal = {Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali},
  year = {2025},
  volume = {10},
  number = {3/1},
  url = {https://tadqiqot.uz/index.php/biomedicine/article/view/12047}
}

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