Insulin-producing function of the pancreas, lipid peroxidation indicators and antioxidant defense systems in rats exposed to lead

KIM Tatyana Aleksandrovna, MAVLYANOVA Zilola Farkhadovna, TASTANOVA Gulchekhra Eshtaevna

Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali · 2024-yil

Annotatsiya

Aim: to study experimentally the insulin-producing function of the pancreas, lipid peroxidation indices and the antioxidant defense system in rats exposed to lead. Materials and methods: The experiment was conducted on 90 outbred male rats weighing 230-270g, divided into 8 groups depending on the intoxication caused: Group 1 - intact, which were administered an equal volume of 0.9% NaCl solution for 30 days; Group 2 - rats that received lead acetate for 30 days - the "lead" group; Group 3 - rats that received potassium dichromate for 30 days - "chromium"; Group 4 - rats that received potassium dichromate + lead acetate for 30 days - "lead + chromium"; Group 5 - alloxan diabetes in intact rats - "control"; Group 6 - alloxan diabetes in rats exposed to lead - "lead + alloxan"; Group 7 – alloxan diabetes in rats exposed to chromium - “chromium + alloxan”; Group 8 – alloxan diabetes in rats exposed to both lead and chromium - “lead + chromium + alloxan”. Results: In the liver of animals of the “lead” group on the 30th day of exposure to lead acetate at a dose of 15 mg/kg body weight, there was a tendency to increase the content of diene conjugates and an increase in the content of malonic dialdehyde by 13% compared to intact animals. Increasing malonic levels dialdehyde in the “lead” group proves the activation of lipid peroxidation processes under metal exposure. The enzymatic activity of superoxide dismutase in the lead group increased by 8% compared to animals that did not receive lead acetate. Catalase activity tended to increase. Activation of superoxide dismutase, initiated by an increased content of free radicals, indicates an intensification of the adaptation mechanisms of hepatocytes in response to the accumulation of free radicals. Conclusions: In rats exposed to lead acetate for 15 days, there was no increase in body weight, which indicates the development of lead intoxication. However, on the 30th day of the experiment, an increase in body weight was observed compared to the initial one by 6%, and compared to the 15th day - by 8.5%. The increase in body weight in the “lead” group indicated the animals’ adaptation to new living conditions. Rats exposed to lead for 30 days were characterized by a decrease in the amount of food eaten, as well as diarrhea. In the second week, these phenomena stopped; the animals did not differ in behavioral reactions and the condition of their fur from intact rats, which is also associated with the development of adaptation of animals to the toxic effects of lead.

Maqola ma’lumotlari
MualliflarKIM Tatyana Aleksandrovna, MAVLYANOVA Zilola Farkhadovna, TASTANOVA Gulchekhra Eshtaevna
JurnalJournal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali
NashriyotТошкент давлат стоматалогия институти, , «Expert Lawyers» MЧЖ
ISSN2181-9300
Nashr sanasi2024-12-25
Jild9
Son5
TilIngliz
Ilmiy sohaTibbiyot
Indeksga qo‘shilgan2026-08-27

Maqolaning asl sahifasi

Kalit so‘zlar

крысы, эксперимент, свинец, хром, аллоксан, эксперимент, поджелудочная железа, функция, антиоксидантная защита, перекисное окисление липидов, rats, experiment, lead, chromium, alloxan, experiment, pancreas, function, antioxidant protection, lipid peroxidation, kalamushlar, tajriba, qo'rg'oshin, xrom, alloksan, oshqozon osti bezi, funktsiya, antioksidant himoya, lipidlarning periksli oksidatsiyasi

Ilmiy soha

Tibbiyot

Iqtibos keltirish

APAKIM Tatyana Aleksandrovna, MAVLYANOVA Zilola Farkhadovna, & TASTANOVA Gulchekhra Eshtaevna (2024). INSULIN-PRODUCING FUNCTION OF THE PANCREAS, LIPID PEROXIDATION INDICATORS AND ANTIOXIDANT DEFENSE SYSTEMS IN RATS EXPOSED TO LEAD. Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali, 9(5). https://tadqiqot.uz/index.php/biomedicine/article/view/10635
GOST (OAK)KIM Tatyana Aleksandrovna, MAVLYANOVA Zilola Farkhadovna, TASTANOVA Gulchekhra Eshtaevna INSULIN-PRODUCING FUNCTION OF THE PANCREAS, LIPID PEROXIDATION INDICATORS AND ANTIOXIDANT DEFENSE SYSTEMS IN RATS EXPOSED TO LEAD // Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali. – 2024. – T. 9, № 5.
MLAKIM Tatyana Aleksandrovna, MAVLYANOVA Zilola Farkhadovna, and TASTANOVA Gulchekhra Eshtaevna. “INSULIN-PRODUCING FUNCTION OF THE PANCREAS, LIPID PEROXIDATION INDICATORS AND ANTIOXIDANT DEFENSE SYSTEMS IN RATS EXPOSED TO LEAD.” Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali, 9(5), 2024. https://tadqiqot.uz/index.php/biomedicine/article/view/10635
ChicagoKIM Tatyana Aleksandrovna, MAVLYANOVA Zilola Farkhadovna, and TASTANOVA Gulchekhra Eshtaevna. “INSULIN-PRODUCING FUNCTION OF THE PANCREAS, LIPID PEROXIDATION INDICATORS AND ANTIOXIDANT DEFENSE SYSTEMS IN RATS EXPOSED TO LEAD.” Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali, 9(5) (2024). https://tadqiqot.uz/index.php/biomedicine/article/view/10635
HarvardKIM Tatyana Aleksandrovna, MAVLYANOVA Zilola Farkhadovna, and TASTANOVA Gulchekhra Eshtaevna (2024) ‘INSULIN-PRODUCING FUNCTION OF THE PANCREAS, LIPID PEROXIDATION INDICATORS AND ANTIOXIDANT DEFENSE SYSTEMS IN RATS EXPOSED TO LEAD’, Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali, 9(5). https://tadqiqot.uz/index.php/biomedicine/article/view/10635
BibTeX
@article{kimtatyanaaleksandrovna2024,
  title = {INSULIN-PRODUCING FUNCTION OF THE PANCREAS, LIPID PEROXIDATION INDICATORS AND ANTIOXIDANT DEFENSE SYSTEMS IN RATS EXPOSED TO LEAD},
  author = {KIM Tatyana Aleksandrovna and MAVLYANOVA Zilola Farkhadovna and TASTANOVA Gulchekhra Eshtaevna},
  journal = {Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali},
  year = {2024},
  volume = {9},
  number = {5},
  url = {https://tadqiqot.uz/index.php/biomedicine/article/view/10635}
}

Boshqa maqola uchun iqtibos tayyorlash

Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali jurnalidan boshqa maqolalar

Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali — barcha maqolalar · 2024-yil arxivi

KIM Tatyana Aleksandrovna — boshqa maqolalari

Tibbiyot sohasidagi boshqa maqolalar

Tibbiyot sohasidagi OAK jurnallari