The study of the chronic toxicity of the drug Colchiprit-neo in rats with oral administration at doses of 30.0, 61.0 and 120 mg/kg for 30 days was carried out. It has been shown that with repeated oral administration to rats, the drug does not affect the behavior and weight dynamics of animals, does not have a toxic effect on the composition of peripheral blood, kidney function, but increases AlAt in the liver, however, after 1 month of the recovery period, all these indicators changed within the physiological norm. A pathomorphological study of the internal organs of rats showed that when applying a dose of 30 mg / kg, toxicity does not manifest itself when affecting the internal parenchymal organs. All the above data allow us to conclude that the drug in a therapeutic dose does not have a toxic effect on the animal body.
| Mualliflar | UROZOV Nuriddin Elmurotovich, VYPOVA Natalia Leonidovna, NISHANOV Danier Anarbaevich, MADALIEV Akhror Alievich, IBRAGIMOV Shavkat Narzikulovich, ENIKEEVA Zulfiya Makhmudovna |
|---|---|
| Jurnal | Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali |
| Nashr sanasi | 2024-12-25 |
| Jild | 9 |
| Son | 5 |
| Til | Rus |
препарат Колхиприт-нео», пероральное введение, хроническая токсичность, Colchiprit-neo drug, oral administration, chronic toxicity
Malignant epithelial ovarian tumors account for 90% of all cases, with serous carcinomas accounting for up to 85%. Due to high molecular and genetic heterogeneity, as well as resistance to chemotherapy, it is difficult…
S100 proteins are small calcium-binding molecules with a specific EF-hand structure. These proteins are found throughout vertebrate bodies and serve many vital functions. Different cell types contain specific sets of…
Primary tumors of the central nervous system unite tumors that differ in histological structure, malignancy and clinical course, common to them is their origin from the tissues that make up the central nervous system…
Benign gallbladder diseases typically present with intraluminal lesions and localized or diffuse wall thickening. Intraluminal lesions of the gallbladder include gallstones, cholesterol polyps, adenomas, or biliary…
Objective: Investigation of morphofunctional changes in the stomach wall in white rats aged 36 weeks exposed to energy drinks using laboratory research methods. Methods: Healthy white male rats participated in the…
Nuclear medicine is a medical field that specializes in the use of radiological methods to diagnose and treat various diseases. In recent decades, radiology has undergone significant changes due to the introduction of…
Aim: to study experimentally the insulin-producing function of the pancreas, lipid peroxidation indices and the antioxidant defense system in rats exposed to lead. Materials and methods: The experiment was conducted on…
Complex treatment was used in 161 patients with chronic polypous rhinosinusitis.In the first group (29 patients) surgery was combined with a symptomatic treatment, in the second group (92 patients) surgical treatment…
The article describes the features of innervation and adrenergic nerve fibers of the extrahepatic bile ducts in rabbits. After experimental cholecystectomy, reactive changes in nerve fibers were observed in the wall of…
170 patients of different age with chronic polypous sinusitis have undergone surgical and medicamentous sanation of the nasal cavity and paranasal sinuses. In al! the cases microflora of the middle nasal passage was…
Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali — barcha maqolalar