Purpose of the study. Conducting a literature analysis of genetic predisposition and risk factors for acne. Research results. Understanding of the molecular and genetic mechanisms underlying acne and acne scar formation is still in its infancy. However, ongoing research in this area increases our knowledge of disease mechanisms and may contribute to the development of new preventive and treatment strategies. Research confirms the significant role of genetic factors in the development of acne, affecting its occurrence, course and effectiveness of treatment. Particular attention is paid to gene polymorphisms associated with inflammation, androgen metabolism and the immune response, such as CYP17A1 and TNF-α. These data highlight the importance of taking patients' genetic profile into account when diagnosing and choosing therapy, which can improve treatment outcomes and prevent disease relapse. Based on an analysis of literature data, in Uzbekistan there is insufficient understanding of the prognostic significance and role of the NLR and TLR2 genes in the development of acne. This highlights the complexity of the genetic component of acne and indicates the need for additional research to better understand the influence of these and other genetic factors on the pathogenesis of the disease. Conclusion. An in-depth study of the genetic aspects of acne will not only enrich the scientific understanding of the disease, but will also open up new opportunities for its more effective treatment and prevention.
| Mualliflar | KHAMIDOVA Farida Muinovna, KHUSINOVA Firuza Azgar kizi |
|---|---|
| Jurnal | Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali |
| Nashr sanasi | 2024-11-05 |
| Jild | 9 |
| Son | 4 |
| Til | Rus |
Акне, молекулярно- генетические механизмы, келлиод, прогноз, Acne, molecular genetic mechanisms, kelliod, prognosis
The most common dental diseases during pregnancy. Causes of the caries process in women during pregnancy. During pregnancy, enamel solubility increases and tooth hard tissue resistance decreases. Prevalence of focal…
The article examines inflammatory processes in oral diseases, with a focus on exudative erythema multiforme (EEM) as an example of a pronounced inflammatory response. The pathogenesis of EEM and the influence of…
Pregnant women are at greatest risk of developing dental disease. According to a number of authors, the prevalence of dental caries during physiological pregnancy is 91.4%, periodontal tissue diseases occur in 90% of…
Disturbances in the intestinal microbiocenosis from the first days of birth in children born after cesarean section increase the risk of developing acute infectious intestinal infections in the future. In this regard…
In the long-term periods of post-resuscitation disease (1 -, 2 -, 3-in months), pathogenetic disorders of the reproductive system are based on an increase in the indicators of the sympathetic nervous system, the…
Vaccinationisoneof the mosteffectiveandcost-effectivemethods of preventinginfectiousdiseases.After the introduction of measles,mumps,rubellaandothervaccinesinto the nationalvaccinationcalendar of the Republic of…
Recently, functional diseases of the gastrointestinal tract are increasingly attracting the attention of specialists. According to numerous epidemiological studies, various functional disorders of the digestive…
The effectiveness of antiprotozoal therapy on the immune status of patients with HIV infection with giardiasis and blastocystosis was characterized, taking into account the determination of CD4+lymphocytes. The study…
Despite the improvement of diagnosis and treatment, the prevalence and death rate of bronchial asthma in the world is increasing year by year. Modern domestic and foreign studies on the assessment of the level of…
60 sick women with various clinical forms of brucellosis were studied. It was established that the content of IL-4 and IL-6 in the peripheral blood of women with acute and chronic forms of brucellosis corresponds to…
Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali — barcha maqolalar