In the present work the mechanism of the action of isoquinoline alkaloid F-25 on the Ca2+-transporting system of rat aortic smooth muscle cells has been investigated. Isometric tension forces were recorded using a force transducer FT-03 (Grass Instrument Co., USA). The results of experiments performed under conditions of KCl- and PE-induced contracture indicate that the studied alkaloids have a pronounced relaxant effect, which is based on a decrease in the level of [Сa2+]in in SMC, due to the blockade of the entry of Ca2+ ions through Ca2+L- and Ca2+R-channels.
| Mualliflar | Зарипов, А.А., Усманов, П.Б., Есимбетов, А.Т., Абдуллаева, Н.У., Жўрақулов, Ш.Н. |
|---|---|
| Jurnal | Ilim ha’m ja’miyet |
| Nashr sanasi | 2023-10-11 |
| Son | 4-1 |
| Betlar | 43-46 |
| Til | Rus |
изохинолин алкалоид, Ca2+-канал, эндотелий, вазорелаксант, α-адренорецепторлар, isoquinoline alkaloid, Ca2+-channel, endothelium, vasorelaxant, α-adrenergic receptors
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