In the present work the mechanism of the action of isoquinoline alkaloid F-25 on the Ca2+-transporting system of rat aortic smooth muscle cells has been investigated. Isometric tension forces were recorded using a force transducer FT-03 (Grass Instrument Co., USA). The results of experiments performed under conditions of KCl- and PE-induced contracture indicate that the studied alkaloids have a pronounced relaxant effect, which is based on a decrease in the level of [Сa2+]in in SMC, due to the blockade of the entry of Ca2+ ions through Ca2+L- and Ca2+R-channels.
| Mualliflar | Зарипов, А.А., Усманов, П.Б., Есимбетов, А.Т., Абдуллаева, Н.У., Жўрақулов, Ш.Н. |
|---|---|
| Jurnal | Ilim ha’m ja’miyet |
| Nashriyot | Нукус давлат педагогика институти |
| ISSN | 2010-720x, 2181-1555 |
| Nashr sanasi | 2023-10-11 |
| Son | 4-1 |
| Betlar | 43-46 |
| Til | Rus |
| Indeksga qo‘shilgan | 2026-08-26 |
изохинолин алкалоид, Ca2+-канал, эндотелий, вазорелаксант, α-адренорецепторлар, isoquinoline alkaloid, Ca2+-channel, endothelium, vasorelaxant, α-adrenergic receptors
| APA | Зарипов, А.А., Усманов, П.Б., Есимбетов, А.Т., Абдуллаева, Н.У., & Жўрақулов, Ш.Н. (2023). F-25 алкалоидиНИнг кАЛАМУШ АОРТА ПРЕПАРАТИГА ВАЗОРЕЛАКСАНТ ТАЪСИРИ. Ilim ha’m ja’miyet, (4-1), 43-46. https://journal.ndpi.uz/index/article/view/2023-4-1-017 |
|---|---|
| GOST (OAK) | Зарипов, А.А. va b. F-25 алкалоидиНИнг кАЛАМУШ АОРТА ПРЕПАРАТИГА ВАЗОРЕЛАКСАНТ ТАЪСИРИ // Ilim ha’m ja’miyet. – 2023. – № 4-1. – С. 43-46. |
| MLA | Зарипов, А.А., Усманов, П.Б., Есимбетов, А.Т., Абдуллаева, Н.У., and Жўрақулов, Ш.Н. “F-25 алкалоидиНИнг кАЛАМУШ АОРТА ПРЕПАРАТИГА ВАЗОРЕЛАКСАНТ ТАЪСИРИ.” Ilim ha’m ja’miyet, (4-1), 43-46, 2023. https://journal.ndpi.uz/index/article/view/2023-4-1-017 |
| Chicago | Зарипов, А.А., Усманов, П.Б., Есимбетов, А.Т., Абдуллаева, Н.У., and Жўрақулов, Ш.Н. “F-25 алкалоидиНИнг кАЛАМУШ АОРТА ПРЕПАРАТИГА ВАЗОРЕЛАКСАНТ ТАЪСИРИ.” Ilim ha’m ja’miyet, (4-1), 43-46 (2023). https://journal.ndpi.uz/index/article/view/2023-4-1-017 |
| Harvard | Зарипов, А.А., Усманов, П.Б., Есимбетов, А.Т., Абдуллаева, Н.У., and Жўрақулов, Ш.Н (2023) ‘F-25 алкалоидиНИнг кАЛАМУШ АОРТА ПРЕПАРАТИГА ВАЗОРЕЛАКСАНТ ТАЪСИРИ’, Ilim ha’m ja’miyet, (4-1), 43-46. https://journal.ndpi.uz/index/article/view/2023-4-1-017 |
| BibTeX | @article{article2023,
title = {F-25 алкалоидиНИнг кАЛАМУШ АОРТА ПРЕПАРАТИГА ВАЗОРЕЛАКСАНТ ТАЪСИРИ},
author = {Зарипов, А.А. and Усманов, П.Б. and Есимбетов, А.Т. and Абдуллаева, Н.У. and Жўрақулов, Ш.Н.},
journal = {Ilim ha’m ja’miyet},
year = {2023},
number = {4-1},
pages = {43-46},
url = {https://journal.ndpi.uz/index/article/view/2023-4-1-017}
} |
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