Каламуш аорта силлиқ мускул ҲужайраСИ қисқаришига F-37 ва N-24 алкалоидларининг РЕЛАКСАНТ ТАЪСИРини ЎРГАНИШ

Жўрақулов, Ш.Н.

Ilim ha’m ja’miyet · 2020-yil

Annotatsiya

In the work the effect of alkaloids F-37 and N-24 on the functional activity of the rat aorta smooth muscle cells has been investigated. Contractile activity of rat aortic smooth muscle, precontracted with high phenylephrine, was evaluated by mechanographic technique using isometric force transducer FT–03 (Grass–Telefactor, USA). Results show that alkaloids F-37 (5-100 mkM ) and N-24 (5-200 mkM) induced concentration-dependent relaxation (IC50=25.7 мкМ and IC50=46.6 мкМ, n = 7) of rat aortic rings. These alkaloids also significantly have reduced the contractions of aortic rings induced by phenylephrine and caffeine in Ca2+-free medium. In conclusion we can say that alkaloids F-37 and N-24 possess potent relaxant effect which is related to inhibition of Ca2+ transport through multiple Ca2+ pathways, including receptor–operated Ca2+–channels, as well as, Ca2+ release from sarcoplasmic reticulum.

Maqola ma’lumotlari
MualliflarЖўрақулов, Ш.Н.
JurnalIlim ha’m ja’miyet
NashriyotНукус давлат педагогика институти
ISSN2010-720x, 2181-1555
Nashr sanasi2020-07-01
Son2-1
Betlar34-37
TilO‘zbek
Ilmiy sohaBiologiya
Indeksga qo‘shilgan2026-08-26

Maqolaning asl sahifasi

Kalit so‘zlar

аорта, саркоплазматик ретикулум, алкалоид, Ca2+ канал, кофеин, aorta, sarcoplasmic reticulum, alkaloid, Ca2+ channel, caffeine

Ilmiy soha

Biologiya

Iqtibos keltirish

APAЖўрақулов, Ш.Н. (2020). Каламуш аорта силлиқ мускул ҲужайраСИ қисқаришига F-37 ва N-24 алкалоидларининг РЕЛАКСАНТ ТАЪСИРини ЎРГАНИШ. Ilim ha’m ja’miyet, (2-1), 34-37. https://journal.ndpi.uz/index/article/view/2020-2-1-016
GOST (OAK)Жўрақулов, Ш.Н. Каламуш аорта силлиқ мускул ҲужайраСИ қисқаришига F-37 ва N-24 алкалоидларининг РЕЛАКСАНТ ТАЪСИРини ЎРГАНИШ // Ilim ha’m ja’miyet. – 2020. – № 2-1. – B. 34-37.
MLAЖўрақулов, Ш.Н. “Каламуш аорта силлиқ мускул ҲужайраСИ қисқаришига F-37 ва N-24 алкалоидларининг РЕЛАКСАНТ ТАЪСИРини ЎРГАНИШ.” Ilim ha’m ja’miyet, (2-1), 34-37, 2020. https://journal.ndpi.uz/index/article/view/2020-2-1-016
ChicagoЖўрақулов, Ш.Н. “Каламуш аорта силлиқ мускул ҲужайраСИ қисқаришига F-37 ва N-24 алкалоидларининг РЕЛАКСАНТ ТАЪСИРини ЎРГАНИШ.” Ilim ha’m ja’miyet, (2-1), 34-37 (2020). https://journal.ndpi.uz/index/article/view/2020-2-1-016
HarvardЖўрақулов, Ш.Н (2020) ‘Каламуш аорта силлиқ мускул ҲужайраСИ қисқаришига F-37 ва N-24 алкалоидларининг РЕЛАКСАНТ ТАЪСИРини ЎРГАНИШ’, Ilim ha’m ja’miyet, (2-1), 34-37. https://journal.ndpi.uz/index/article/view/2020-2-1-016
BibTeX
@article{article2020,
  title = {Каламуш аорта силлиқ мускул ҲужайраСИ қисқаришига F-37 ва N-24 алкалоидларининг РЕЛАКСАНТ ТАЪСИРини ЎРГАНИШ},
  author = {Жўрақулов, Ш.Н.},
  journal = {Ilim ha’m ja’miyet},
  year = {2020},
  number = {2-1},
  pages = {34-37},
  url = {https://journal.ndpi.uz/index/article/view/2020-2-1-016}
}

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