To date, the search for new pharmacological methods for the prevention and treatment of diseases of the cardiovascular system is one of the urgent problems of modern pharmacology and medicine. Of particular interest is the fact that isoquinoline alkaloids currently have a pronounced antiarrhythmic effect. In our studies, it was found that the isoquinoline alkaloid F-27 has a negative inotropic effect on the contractile activity of the papillary muscle of the rat heart. It has been proven that the negative inotropic effect of this alkaloid is partly due to the blockade of Ca2+-channels. Experiments with lidocaine show that the negative inotropic effect of the F-27 alkaloid is mainly due to the blocking of Na+-channels.
| Mualliflar | Жумаев, И.З., Бобоев, С.Н., Усманов, П.Б., Есимбетов, А.Т., Жўрақулов, Ш.Н. |
|---|---|
| Jurnal | Ilim ha’m ja’miyet |
| Nashr sanasi | 2022-10-11 |
| Son | 4-1 |
| Betlar | 22-25 |
| Til | O‘zbek |
изохинолин, кардиомиоцит, папилляр мускул, ион канал, isoquinoline, cardiomyocyte, papillary muscle, ion channel
Adverse environmental factors, such as high temperatures in July and August, the shortage of water resources has led to an excessive drying of the soil and as a consequence - the weakening the tree stand and the death…
On the basis of research on parameters of the higher manganese layer silicide it was established that current carriers in the formed manganese silicide are holes and their concentration is equal to , mobility of wound…
This article discusses the distribution of Epicauta erythrocephala in the natural and anthropogenic zones of the Southern Aral Sea, bioecological features and the benefits of Epicauta erythrocephala species in the…
In the article there was studied the effect of samples containing crushed sodium silicate in the composition of the composite binder on the strength properties.
The article reveals the essence of the concept of green urbanism. The studies carried out in this area in the world and their main content are described. The basic principles of green urbanism and practical measures and…
The paper considers the problem of diffraction of non-stationary transverse shear waves on a spherical inclusion in a porous-elastic space saturated with liquid. Numerical experiments were carried out, the results of…
This article explores the role and importance of water objects in the formation of toponyms in the territory of the Republic of Karakalpakstan from a geographical point of view. Oikonyms and local geographical terms…
The article considers the superconductivity of cuprate La2-xSrxCuO4 within the framework of the Holstein-Hubbard model and the approximation of bipolaronic superconductivity. The temperature of the Bose-Einstein…
The article tried to evaluate the role and importance of religious and pilgrimage tourism in the economy of small areas (towns where shrines are located) based on observations and sociological studies in a number of…
The article describes the intelligent control system of traffic lights that is a multilayer neural network that solves optimization and clustering problems. Also, the paper discusses the problems of combining…