Study of molecular-genetic features metachronous breast cancer

KAMISHOV Sergey Viktorovich, ISROILBEKOVA Kamila Shavkatovna, BALENKOV Oleg Yurievich

Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali · 2022-yil

Annotatsiya

Objective: to study the level of tumor markers and the frequency of mutations in the BRCA1/2 genes in metachronous breast cancer (BC). Methods: In 58 patients with BC with II-III clinical stages of the disease and metachronous oncogynecological tumors, the level of tumor markers and mutations in the BRCA1/2 genes were studied. Results: ELISA analysis of the level of tumor markers in patients with BC showed that in the development of metachronous cancer, the studied markers were more common than in the control group. At the same time, an excess of levels significant for diagnosis was observed for CA-125, CA-15-3 and CA-19-9 in both groups of patients, but in the group of patients with BC with metachronous tumors, these indicators were above the norm by an average of 2-3 times . The total frequency of occurrence of patients with clinically significant germline mutations in the BRCA1/2 genes in the control group was 5 (15.6%), while this figure occurred in 16 (61.5%) patients with BC with metachronous tumors. Conclusions. Dynamic study of the level of tumor markers CA-125 and CA-15-3 and CA-19-9 may be useful in the preventive examination of patients with a history of BC as an early diagnosis of the development of metachronous tumors in them. The most important diagnostic unfavorable factor in the development of metachronous tumors in BC patients was germline mutations in the BRCA1/2 genes.

Maqola ma’lumotlari
MualliflarKAMISHOV Sergey Viktorovich, ISROILBEKOVA Kamila Shavkatovna, BALENKOV Oleg Yurievich
JurnalJournal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali
NashriyotТошкент давлат стоматалогия институти, , «Expert Lawyers» MЧЖ
ISSN2181-9300
Nashr sanasi2022-08-30
Jild7
Son3
TilIngliz
Ilmiy sohaTibbiyot
Indeksga qo‘shilgan2026-08-27

Maqolaning asl sahifasi

Kalit so‘zlar

гены BRCA1/2, метахронные опухоли, онкомаркеры, первично-множественные злокачественные опухоли, рак молочной железы, BRCA1/2 genes, breast cancer, metachronous tumors, primary multiple malignant tumors, tumor markers, BRCA1/2 genlari, metaxron o'smalar, onkomarkerlar, birlamchi-ko’plab xavfli o'smalar, sut bezi saratoni

Ilmiy soha

Tibbiyot

Iqtibos keltirish

APAKAMISHOV Sergey Viktorovich, ISROILBEKOVA Kamila Shavkatovna, & BALENKOV Oleg Yurievich (2022). STUDY OF MOLECULAR-GENETIC FEATURES METACHRONOUS BREAST CANCER. Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali, 7(3). https://tadqiqot.uz/index.php/biomedicine/article/view/5398
GOST (OAK)KAMISHOV Sergey Viktorovich, ISROILBEKOVA Kamila Shavkatovna, BALENKOV Oleg Yurievich STUDY OF MOLECULAR-GENETIC FEATURES METACHRONOUS BREAST CANCER // Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali. – 2022. – T. 7, № 3.
MLAKAMISHOV Sergey Viktorovich, ISROILBEKOVA Kamila Shavkatovna, and BALENKOV Oleg Yurievich. “STUDY OF MOLECULAR-GENETIC FEATURES METACHRONOUS BREAST CANCER.” Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali, 7(3), 2022. https://tadqiqot.uz/index.php/biomedicine/article/view/5398
ChicagoKAMISHOV Sergey Viktorovich, ISROILBEKOVA Kamila Shavkatovna, and BALENKOV Oleg Yurievich. “STUDY OF MOLECULAR-GENETIC FEATURES METACHRONOUS BREAST CANCER.” Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali, 7(3) (2022). https://tadqiqot.uz/index.php/biomedicine/article/view/5398
HarvardKAMISHOV Sergey Viktorovich, ISROILBEKOVA Kamila Shavkatovna, and BALENKOV Oleg Yurievich (2022) ‘STUDY OF MOLECULAR-GENETIC FEATURES METACHRONOUS BREAST CANCER’, Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali, 7(3). https://tadqiqot.uz/index.php/biomedicine/article/view/5398
BibTeX
@article{kamishovsergeyviktorovich2022,
  title = {STUDY OF MOLECULAR-GENETIC FEATURES METACHRONOUS BREAST CANCER},
  author = {KAMISHOV Sergey Viktorovich and ISROILBEKOVA Kamila Shavkatovna and BALENKOV Oleg Yurievich},
  journal = {Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali},
  year = {2022},
  volume = {7},
  number = {3},
  url = {https://tadqiqot.uz/index.php/biomedicine/article/view/5398}
}

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