The most clinically significant polymorphic markers of the CYP2C9 gene are the amino acid substitutions CYP2C9*2 (substitution in the 144 position of the polypeptide chain, leading to the substitution of the amino acid arginine for cysteine; 144Arg) and CYP2C9*3 (substitution in the 359 position of the polypeptide chain, leading to the substitution of the amino acid isoleucine for leucine; 359Leu). Nonsteroidal anti-inflammatory drugs (NSAIDs) are a group of widely used drugs. An important problem when taking NSAIDs are adverse drug reactions from the gastrointestinal tract at various levels - from dyspepsia to life-threatening complications such as bleeding or wound perforation. The formation of the risk of adverse drug reactions can be attributed to genetic factors, in particular, the polymorphism of the CYP2C9 gene. It has been shown that carriers of the "slow" alleles of the CYP2C9 gene (*2, *3) are more likely to develop gastric bleeding when taking NSAIDs (selecoxib, diclofenac, ibuprofen, naproxen or piroxicam).
| Mualliflar | DAMINOVA Lola Turgunpulatovna, ABDASHIMOV Zafar Bakhtiyarovich |
|---|---|
| Jurnal | Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali |
| Nashr sanasi | 2022-08-30 |
| Jild | 7 |
| Son | 3 |
| Til | Rus |
аллели, генотипы, изоферменты, волонтеры, узбекская национальность, alleles, genotypes, isoenzymes, volunteers, Uzbek nationality, аллеллар, генотиплар, изоензимлар, кўнгиллилар, ўзбек миллати
Objective: To study the morphological features of cystic and tumor-like formations of the ovaries in adolescents. Methods: The study included data from 167 adolescents who were treated for cystic and tumor-like ovarian…
Juvenile rheumatoid (ideopathic) arthritis refers to rheumatic diseases that can lead to neurological complications, as well as disorders of the psycho-emotional and cognitive spheres. Damage to the nervous system in…
Objective: Analysis of the results of treatment of patients with congenital tracheoesophageal fistula Methods: In the period from 2016 to 2021, 9 patients with suspected isolated tracheoesophageal leakage were…
Purpose: to identify and diagnose Cherdja-Stross syndrome, which is rare in adult patients. Materials and methods. Although this condition is a very rare disease - a 64-year-old patient was diagnosed with Cherdja-Stross…
Objective: Optimization of surgical tactics for the treatment of uroandrological pathology in children. Methods. An open prospective and retrospective study of clinical material was conducted using statistical and…
In recent years, the incidence of gynecological malignancies during pregnancy has increased, mainly due to an increase in the number of pregnant women in old age. The most common gynecological malignancies during…
Anorectal malformations in the world. Anorectal malformations (ARM) are one of the medical problems that lead to early disability. According to the World Health Organization (WHO), "... more than 303,000 children die…
The review discusses the methods for ensuring the main tasks of preventive and individualized premedication, the use of various groups of pharmacological agents as part…
The article presents the data of examination of 731 children with various forms of anomalies of fixation and lengthening of the colon. The features of the clinical course are analyzed anatomical forms are verified…
Target. To study the efficacy and safety of using dexmedetomidine to stabilize hemodynamics and arousal in pregnant women of various categories during caesarean section. Material and methods. Under observation were 50…
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