Prevalence of alleles and genotypes of two cytochrome P450 hepatic system isoenzymes (CYP2C19 and CYP2C9) and the MDR1 gene among healthy volunteers of uzbek nationality

DAMINOVA Lola Turgunpulatovna, ABDASHIMOV Zafar Bakhtiyarovich

Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali · 2022-yil

Annotatsiya

The most clinically significant polymorphic markers of the CYP2C9 gene are the amino acid substitutions CYP2C9*2 (substitution in the 144 position of the polypeptide chain, leading to the substitution of the amino acid arginine for cysteine; 144Arg) and CYP2C9*3 (substitution in the 359 position of the polypeptide chain, leading to the substitution of the amino acid isoleucine for leucine; 359Leu). Nonsteroidal anti-inflammatory drugs (NSAIDs) are a group of widely used drugs. An important problem when taking NSAIDs are adverse drug reactions from the gastrointestinal tract at various levels - from dyspepsia to life-threatening complications such as bleeding or wound perforation. The formation of the risk of adverse drug reactions can be attributed to genetic factors, in particular, the polymorphism of the CYP2C9 gene. It has been shown that carriers of the "slow" alleles of the CYP2C9 gene (*2, *3) are more likely to develop gastric bleeding when taking NSAIDs (selecoxib, diclofenac, ibuprofen, naproxen or piroxicam).

Maqola ma’lumotlari
MualliflarDAMINOVA Lola Turgunpulatovna, ABDASHIMOV Zafar Bakhtiyarovich
JurnalJournal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali
NashriyotТошкент давлат стоматалогия институти, , «Expert Lawyers» MЧЖ
ISSN2181-9300
Nashr sanasi2022-08-30
Jild7
Son3
TilIngliz
Ilmiy sohaTibbiyot
Indeksga qo‘shilgan2026-08-27

Maqolaning asl sahifasi

Kalit so‘zlar

аллели, генотипы, изоферменты, волонтеры, узбекская национальность, alleles, genotypes, isoenzymes, volunteers, Uzbek nationality, аллеллар, генотиплар, изоензимлар, кўнгиллилар, ўзбек миллати

Ilmiy soha

Tibbiyot

Iqtibos keltirish

APADAMINOVA Lola Turgunpulatovna, & ABDASHIMOV Zafar Bakhtiyarovich (2022). PREVALENCE OF ALLELES AND GENOTYPES OF TWO CYTOCHROME P450 HEPATIC SYSTEM ISOENZYMES (CYP2C19 and CYP2C9) AND THE MDR1 GENE AMONG HEALTHY VOLUNTEERS OF UZBEK NATIONALITY. Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali, 7(3). https://tadqiqot.uz/index.php/biomedicine/article/view/5374
GOST (OAK)DAMINOVA Lola Turgunpulatovna, ABDASHIMOV Zafar Bakhtiyarovich PREVALENCE OF ALLELES AND GENOTYPES OF TWO CYTOCHROME P450 HEPATIC SYSTEM ISOENZYMES (CYP2C19 and CYP2C9) AND THE MDR1 GENE AMONG HEALTHY VOLUNTEERS OF UZBEK NATIONALITY // Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali. – 2022. – T. 7, № 3.
MLADAMINOVA Lola Turgunpulatovna, and ABDASHIMOV Zafar Bakhtiyarovich. “PREVALENCE OF ALLELES AND GENOTYPES OF TWO CYTOCHROME P450 HEPATIC SYSTEM ISOENZYMES (CYP2C19 and CYP2C9) AND THE MDR1 GENE AMONG HEALTHY VOLUNTEERS OF UZBEK NATIONALITY.” Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali, 7(3), 2022. https://tadqiqot.uz/index.php/biomedicine/article/view/5374
ChicagoDAMINOVA Lola Turgunpulatovna, and ABDASHIMOV Zafar Bakhtiyarovich. “PREVALENCE OF ALLELES AND GENOTYPES OF TWO CYTOCHROME P450 HEPATIC SYSTEM ISOENZYMES (CYP2C19 and CYP2C9) AND THE MDR1 GENE AMONG HEALTHY VOLUNTEERS OF UZBEK NATIONALITY.” Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali, 7(3) (2022). https://tadqiqot.uz/index.php/biomedicine/article/view/5374
HarvardDAMINOVA Lola Turgunpulatovna, and ABDASHIMOV Zafar Bakhtiyarovich (2022) ‘PREVALENCE OF ALLELES AND GENOTYPES OF TWO CYTOCHROME P450 HEPATIC SYSTEM ISOENZYMES (CYP2C19 and CYP2C9) AND THE MDR1 GENE AMONG HEALTHY VOLUNTEERS OF UZBEK NATIONALITY’, Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali, 7(3). https://tadqiqot.uz/index.php/biomedicine/article/view/5374
BibTeX
@article{daminovalolaturgunpulatovna2022,
  title = {PREVALENCE OF ALLELES AND GENOTYPES OF TWO CYTOCHROME P450 HEPATIC SYSTEM ISOENZYMES (CYP2C19 and CYP2C9) AND THE MDR1 GENE AMONG HEALTHY VOLUNTEERS OF UZBEK NATIONALITY},
  author = {DAMINOVA Lola Turgunpulatovna and ABDASHIMOV Zafar Bakhtiyarovich},
  journal = {Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali},
  year = {2022},
  volume = {7},
  number = {3},
  url = {https://tadqiqot.uz/index.php/biomedicine/article/view/5374}
}

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