Antibacterial drugs, as well as their combinations, are widely used in clinical practice. Irrational combinations in antibacterial therapy can lead to adverse drug reactions and/or increased costs in the healthcare system, as well as to the development of microbial resistance to antibacterial drugs as a result of a decrease in the effectiveness of pharmacotherapy. In 27% of cases of respiratory diseases, combined antibacterial therapy was performed, in 93% of cases, combination therapy consisted of 2 antibacterial drugs, in the remaining 7% of cases, combination therapy consisted of 3 antibacterial drugs. In 10% of cases, respiratory diseases were accompanied by liver and kidney damage, and the nephrotoxicity or hepatotoxicity of antibacterial drugs used in combination therapy and their pharmacokinetic properties were not taken into account.
| Mualliflar | Сиддиков Олим Абдуллаевич, Даминова Лола Тургунпулатовна, Нуралиева Рано Матякубовна |
|---|---|
| Jurnal | Journal of cardiorespiratory research/Kardiorespirator tadqiqotlar jurnali |
| Nashr sanasi | 2022-07-29 |
| Til | O‘zbek |
комбинированная терапия, антибактериальные препараты, полипрагмазия, combination therapy, antibacterial drugs, polypragmasia, kombinirlangan terapiya, antibakterial preparatlar, polipragmaziya
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