Polymorphism of MDR1 gene – resistance markers to chemotherapy AT oncological diseases

KADIROVA Dilbar Abdullaevna, Alimxodjaev Lola Telmanovna, Ibrgimov Adil Ahmedovich

Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali · 2022-yil

Annotatsiya

Purpose: Determination of a personal genotype of drug stability of cancer patients according to polymorphic marker 3435T MDR1 gene to predict individual chemotherapy regime. Methods: During the implementation of studies, DNA samples obtained from peripheral blood leukocytes of patients suffering from breast cancer (BC) (80 patients) and NHL (75 patients) were used. Results: Identifying genetic features in patients in the polymorphic marker C3435T gene MDR1 allows you to predict the nature of the pharmacological response, which makes it possible to improve the efficiency and safety of drug use - dose, the multiplicity of administration, the path of administration, the replacement of medicines and the real possibility of individualization of pharmacotherapy with various oncological diseases. The frequency of occurrence of genotypes among healthy donors and oncological patients with diagnosis of breast cancer and non-Hodgkin's lymphoma was carried out. Conclusions: It has been shown that the frequency of occurrence of homozygous TT genotype in breast cancer and Non-Hodgkin's lymphoma is higher than the occurrence of CC and CT genotypes.

Maqola ma’lumotlari
MualliflarKADIROVA Dilbar Abdullaevna, Alimxodjaev Lola Telmanovna, Ibrgimov Adil Ahmedovich
JurnalJournal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali
NashriyotТошкент давлат стоматалогия институти, , «Expert Lawyers» MЧЖ
ISSN2181-9300
Nashr sanasi2022-05-31
Jild7
Son2
TilIngliz
Ilmiy sohaTibbiyot
Indeksga qo‘shilgan2026-08-27

Maqolaning asl sahifasi

Kalit so‘zlar

вкДНК, полиморфизм, MDR1, С3435Т, РМЖ, НХЛ, Рак, DNA, polymorphism, MDR1, C3435T, BC, NHL, Cancer, DNA, polimorfizm, MDR1, C3435T, SBS, NHL, Saraton

Ilmiy soha

Tibbiyot

Iqtibos keltirish

APAKADIROVA Dilbar Abdullaevna, Alimxodjaev Lola Telmanovna, & Ibrgimov Adil Ahmedovich (2022). POLYMORPHISM OF MDR1 GENE – RESISTANCE MARKERS TO CHEMOTHERAPY AT ONCOLOGICAL DISEASES. Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali, 7(2). https://tadqiqot.uz/index.php/biomedicine/article/view/4684
GOST (OAK)KADIROVA Dilbar Abdullaevna, Alimxodjaev Lola Telmanovna, Ibrgimov Adil Ahmedovich POLYMORPHISM OF MDR1 GENE – RESISTANCE MARKERS TO CHEMOTHERAPY AT ONCOLOGICAL DISEASES // Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali. – 2022. – T. 7, № 2.
MLAKADIROVA Dilbar Abdullaevna, Alimxodjaev Lola Telmanovna, and Ibrgimov Adil Ahmedovich. “POLYMORPHISM OF MDR1 GENE – RESISTANCE MARKERS TO CHEMOTHERAPY AT ONCOLOGICAL DISEASES.” Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali, 7(2), 2022. https://tadqiqot.uz/index.php/biomedicine/article/view/4684
ChicagoKADIROVA Dilbar Abdullaevna, Alimxodjaev Lola Telmanovna, and Ibrgimov Adil Ahmedovich. “POLYMORPHISM OF MDR1 GENE – RESISTANCE MARKERS TO CHEMOTHERAPY AT ONCOLOGICAL DISEASES.” Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali, 7(2) (2022). https://tadqiqot.uz/index.php/biomedicine/article/view/4684
HarvardKADIROVA Dilbar Abdullaevna, Alimxodjaev Lola Telmanovna, and Ibrgimov Adil Ahmedovich (2022) ‘POLYMORPHISM OF MDR1 GENE – RESISTANCE MARKERS TO CHEMOTHERAPY AT ONCOLOGICAL DISEASES’, Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali, 7(2). https://tadqiqot.uz/index.php/biomedicine/article/view/4684
BibTeX
@article{kadirovadilbarabdullaevna2022,
  title = {POLYMORPHISM OF MDR1 GENE – RESISTANCE MARKERS TO CHEMOTHERAPY AT ONCOLOGICAL DISEASES},
  author = {KADIROVA Dilbar Abdullaevna and Alimxodjaev Lola Telmanovna and Ibrgimov Adil Ahmedovich},
  journal = {Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali},
  year = {2022},
  volume = {7},
  number = {2},
  url = {https://tadqiqot.uz/index.php/biomedicine/article/view/4684}
}

Boshqa maqola uchun iqtibos tayyorlash

Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali jurnalidan boshqa maqolalar

Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali — barcha maqolalar · 2022-yil arxivi

Tibbiyot sohasidagi boshqa maqolalar

Tibbiyot sohasidagi OAK jurnallari