Study of the antitumor activity of the drug colhametin (K-2) on 2 solid tumors of mice in comparison with a number of cytostatics

YULDASHEV Zhovlon Abduraim-ugly, ABDUKHALILOV Majid Mamatkulovich, RAKHIMOV Nodir Maxammatkulovich, ENIKEEVA Zulfiya Makhmudovna, IBRAGIMOV Shavkat Narzikulovich

Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali · 2022-yil

Annotatsiya

The aim of the study was to study the antitumor activity of the new antitumor drug "colhametin" (K-2) on 2 tumor strains. Material and research methods. The study of antitumor activity was performed on 42 outbred and 34 strain mice with transplanted tumors Ehrlich's solid tumor (EST) and AKATOL, which were injected with drugs on the 4th day after tumor inoculation 10 times. The results were evaluated according to standard criteria: tumor growth inhibition (TGI), body weight and spleen weight of animals. Differences were considered significant at p<0.05. Results. The study of the activity of the new developed antitumor drug colhametin (K-2) revealed that the drug inhibits the growth of tumors: AKATOL by 94/91%, Erlikhan's solid tumor by 92/78%, more than 50% more active than colhamin and 9- 20% more active than taxol and etoposide. Conclusions. The studied substance can be submitted for clinical trials, as it meets the requirements for a promising anticancer drug, in addition, its activity is higher than the effect of drugs used for comparison.

Maqola ma’lumotlari
MualliflarYULDASHEV Zhovlon Abduraim-ugly, ABDUKHALILOV Majid Mamatkulovich, RAKHIMOV Nodir Maxammatkulovich, ENIKEEVA Zulfiya Makhmudovna, IBRAGIMOV Shavkat Narzikulovich
JurnalJournal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali
NashriyotТошкент давлат стоматалогия институти, , «Expert Lawyers» MЧЖ
ISSN2181-9300
Nashr sanasi2022-05-31
Jild7
Son2
TilIngliz
Ilmiy sohaTibbiyot
Indeksga qo‘shilgan2026-08-27

Maqolaning asl sahifasi

Kalit so‘zlar

противоопуопухолевая активность, новый препарат К-2, Солидная опухоли Эрлиха АКАТОЛ, препараты сравнения, побочный эффект, antitumor activity, new drug K-2, Ehrlich solid tumor AKATOL, comparator drugs, side effect., o'smaga qarshi faollik, yangi K-2 preparati, Erlix solid o'smasi AKATOL, solishtirma dorilar, nojo'ya ta'sir

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APAYULDASHEV Zhovlon Abduraim-ugly, ABDUKHALILOV Majid Mamatkulovich, RAKHIMOV Nodir Maxammatkulovich, ENIKEEVA Zulfiya Makhmudovna, & IBRAGIMOV Shavkat Narzikulovich (2022). STUDY OF THE ANTITUMOR ACTIVITY OF THE DRUG COLHAMETIN (K-2) ON 2 SOLID TUMORS OF MICE IN COMPARISON WITH A NUMBER OF CYTOSTATICS. Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali, 7(2). https://tadqiqot.uz/index.php/biomedicine/article/view/4682
GOST (OAK)YULDASHEV Zhovlon Abduraim-ugly va b. STUDY OF THE ANTITUMOR ACTIVITY OF THE DRUG COLHAMETIN (K-2) ON 2 SOLID TUMORS OF MICE IN COMPARISON WITH A NUMBER OF CYTOSTATICS // Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali. – 2022. – T. 7, № 2.
MLAYULDASHEV Zhovlon Abduraim-ugly, ABDUKHALILOV Majid Mamatkulovich, RAKHIMOV Nodir Maxammatkulovich, ENIKEEVA Zulfiya Makhmudovna, and IBRAGIMOV Shavkat Narzikulovich. “STUDY OF THE ANTITUMOR ACTIVITY OF THE DRUG COLHAMETIN (K-2) ON 2 SOLID TUMORS OF MICE IN COMPARISON WITH A NUMBER OF CYTOSTATICS.” Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali, 7(2), 2022. https://tadqiqot.uz/index.php/biomedicine/article/view/4682
ChicagoYULDASHEV Zhovlon Abduraim-ugly, ABDUKHALILOV Majid Mamatkulovich, RAKHIMOV Nodir Maxammatkulovich, ENIKEEVA Zulfiya Makhmudovna, and IBRAGIMOV Shavkat Narzikulovich. “STUDY OF THE ANTITUMOR ACTIVITY OF THE DRUG COLHAMETIN (K-2) ON 2 SOLID TUMORS OF MICE IN COMPARISON WITH A NUMBER OF CYTOSTATICS.” Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali, 7(2) (2022). https://tadqiqot.uz/index.php/biomedicine/article/view/4682
HarvardYULDASHEV Zhovlon Abduraim-ugly, ABDUKHALILOV Majid Mamatkulovich, RAKHIMOV Nodir Maxammatkulovich, ENIKEEVA Zulfiya Makhmudovna, and IBRAGIMOV Shavkat Narzikulovich (2022) ‘STUDY OF THE ANTITUMOR ACTIVITY OF THE DRUG COLHAMETIN (K-2) ON 2 SOLID TUMORS OF MICE IN COMPARISON WITH A NUMBER OF CYTOSTATICS’, Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali, 7(2). https://tadqiqot.uz/index.php/biomedicine/article/view/4682
BibTeX
@article{yuldashevzhovlonabduraimugly2022,
  title = {STUDY OF THE ANTITUMOR ACTIVITY OF THE DRUG COLHAMETIN (K-2) ON 2 SOLID TUMORS OF MICE IN COMPARISON WITH A NUMBER OF CYTOSTATICS},
  author = {YULDASHEV Zhovlon Abduraim-ugly and ABDUKHALILOV Majid Mamatkulovich and RAKHIMOV Nodir Maxammatkulovich and ENIKEEVA Zulfiya Makhmudovna and IBRAGIMOV Shavkat Narzikulovich},
  journal = {Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali},
  year = {2022},
  volume = {7},
  number = {2},
  url = {https://tadqiqot.uz/index.php/biomedicine/article/view/4682}
}

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