Objective: to carry out comparative analysis of matrix metalloproteinase’s-2,9 (MMP-2, 9), tissue inhibitors of matrix metalloproteinase’s (TIMP) expression indexes and their interconnection with magnesium ions (Mg2+), glucosamine-glycans and glucuronidases activity in the blood of patients with undifferentiated connective tissue dysplasia. Material and research methods. 208 persons of them aged 15-25 (19.9±1.42) years have been studied. Depending on clinical signs and progressive complications, patients were divided into 2 groups, 1-group 97 patients with signs of external phenotypes (fens) of BTDD, 2-group 111 patients with signs of external and internal fens, with some complications. Results of researches have shown that the blood of patients with BTDD showed an increase in MMP-2 and MMP-9 and a decrease in TIMP-1. As the progression of the disease increases, the expression of MMP-2 and MMP-9 increases and the TIMP-1 decreases, compared to the data in the control group. At the same time, in patients there is a decrease in Mg 2 ions in blood. Thus, dynamics of changes of MMP-2 and MMP-9 and also TIMP-1 expression in patients with undifferentiated connective tissue dysplasia may serve as a method of estimation of progressive pathological process and prognosis of the disease.
| Mualliflar | Gulandom Zikriyaevna Shodikulova, Zarrina Baxtiyarovna Babamuradova, Ozod Voxidovich Mirzaev |
|---|---|
| Jurnal | Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali |
| Nashriyot | Тошкент давлат стоматалогия институти, , «Expert Lawyers» MЧЖ |
| ISSN | 2181-9300 |
| Nashr sanasi | 2021-02-26 |
| Jild | 6 |
| Son | 1 |
| Til | Ingliz |
| Ilmiy soha | Tibbiyot |
| Indeksga qo‘shilgan | 2026-08-27 |
Недифференцированная дисплазия соединительной ткани, металлопротеиназы, тканевые ингибиторы металлопротеиназ, ионы магния (Mg 2), undifferentiated connective tissue dysplasia, matrix metalloproteinase’s, inhibitors of matrix metalloproteinase’s, magnesium (Mg2 ) ions, Biriktiruvchi to'qima differentsiyalanmagan displaziyasi, metalloproteinazlar, metalloproteinazalarning to'qima ingibitorlari, magniy ionlari (Mg 2)
| APA | Gulandom Zikriyaevna Shodikulova, Zarrina Baxtiyarovna Babamuradova, & Ozod Voxidovich Mirzaev (2021). STUDY OF THE STATE OF TISSUE REMODELING IN PERSONS WITH UNDIFFERENTIATED CONNECTIVE TISSUE DISPLASI. Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali, 6(1). https://tadqiqot.uz/index.php/biomedicine/article/view/203 |
|---|---|
| GOST (OAK) | Gulandom Zikriyaevna Shodikulova, Zarrina Baxtiyarovna Babamuradova, Ozod Voxidovich Mirzaev STUDY OF THE STATE OF TISSUE REMODELING IN PERSONS WITH UNDIFFERENTIATED CONNECTIVE TISSUE DISPLASI // Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali. – 2021. – T. 6, № 1. |
| MLA | Gulandom Zikriyaevna Shodikulova, Zarrina Baxtiyarovna Babamuradova, and Ozod Voxidovich Mirzaev. “STUDY OF THE STATE OF TISSUE REMODELING IN PERSONS WITH UNDIFFERENTIATED CONNECTIVE TISSUE DISPLASI.” Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali, 6(1), 2021. https://tadqiqot.uz/index.php/biomedicine/article/view/203 |
| Chicago | Gulandom Zikriyaevna Shodikulova, Zarrina Baxtiyarovna Babamuradova, and Ozod Voxidovich Mirzaev. “STUDY OF THE STATE OF TISSUE REMODELING IN PERSONS WITH UNDIFFERENTIATED CONNECTIVE TISSUE DISPLASI.” Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali, 6(1) (2021). https://tadqiqot.uz/index.php/biomedicine/article/view/203 |
| Harvard | Gulandom Zikriyaevna Shodikulova, Zarrina Baxtiyarovna Babamuradova, and Ozod Voxidovich Mirzaev (2021) ‘STUDY OF THE STATE OF TISSUE REMODELING IN PERSONS WITH UNDIFFERENTIATED CONNECTIVE TISSUE DISPLASI’, Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali, 6(1). https://tadqiqot.uz/index.php/biomedicine/article/view/203 |
| BibTeX | @article{gulandomzikriyaevnashodikulova2021,
title = {STUDY OF THE STATE OF TISSUE REMODELING IN PERSONS WITH UNDIFFERENTIATED CONNECTIVE TISSUE DISPLASI},
author = {Gulandom Zikriyaevna Shodikulova and Zarrina Baxtiyarovna Babamuradova and Ozod Voxidovich Mirzaev},
journal = {Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali},
year = {2021},
volume = {6},
number = {1},
url = {https://tadqiqot.uz/index.php/biomedicine/article/view/203}
} |
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